Consensus statements on vaccination in patients with haemophilia-Results from the Italian haemophilia and vaccinations (HEVA) project.
bleeding disorder
factor VIII inhibitor
haemophilia
immunization
vaccination
Journal
Haemophilia : the official journal of the World Federation of Hemophilia
ISSN: 1365-2516
Titre abrégé: Haemophilia
Pays: England
ID NLM: 9442916
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
29
11
2018
revised:
15
03
2019
accepted:
15
03
2019
pubmed:
17
4
2019
medline:
19
12
2019
entrez:
17
4
2019
Statut:
ppublish
Résumé
Vaccination against communicable diseases is crucial for disease prevention, but this practice poses challenges to healthcare professionals in patients with haemophilia. Poor knowledge of the vaccination requirements for these patients and safety concerns often result in vaccination delay or avoidance. In order to address this issue, a panel of 11 Italian haemophilia and immunization experts conducted a Delphi consensus process to identify the main concerns regarding the safe use of vaccines in patients with haemophilia. The consensus was based on a literature search of the available evidence, which was used by the experts to design 27 consensus statements. A group of clinicians then rated these statements using the 5-point Likert-type scale (1 = strongly disagree; 5 = strongly agree). The main issues identified by the expert panel included vaccination schedule for haemophilic patients; protocol and optimal route of vaccine administration; vaccination of haemophilic patients with antibodies inhibiting coagulation factor VIII (inhibitors); and vaccination and risk of inhibitor development. This manuscript discusses these controversial areas in detail supported by the available literature evidence and provides evidence- and consensus-based recommendations. Overall, participants agreed on most statements, except those addressing the potential role of vaccination in inhibitor formation. Participants agreed that patients with haemophilia should receive vaccinations according to the institutional schedule for individuals without bleeding disorders; however, vaccination of patients with haemophilia requires comprehensive planning, taking into account disease severity, type and route of vaccination, and bleeding risk. Data also suggest vaccination timing does not need to take into consideration when the patient received factor VIII replacement.
Identifiants
pubmed: 30990961
doi: 10.1111/hae.13756
pmc: PMC6850056
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
656-667Subventions
Organisme : Sobi, Milan, Italy
Investigateurs
Chiara Ambaglio
(C)
Anna Brigida Aru
(A)
Erminia Baldacci
(E)
Giovanni Barillari
(G)
Maria Basso
(M)
Sayla Bernasconi
(S)
Marta Bertamino
(M)
Elisa Bertoni
(E)
Chiara Biasoli
(C)
Eugenia Federica Biguzzi
(E)
Elisa Bonetti
(E)
Alessandra Borchiellini
(A)
Simona Bulgarelli
(S)
Sergio Cabibbo
(S)
Isabella Cantori
(I)
Giancarlo Castaman
(G)
Paolo Castiglia
(P)
Antonella Coluccia
(A)
Ugo Coppetelli
(U)
Antonio Coppola
(A)
Dorina Cultrera
(D)
Erica De Candia
(E)
Grazia Delios
(G)
Leonardo Di Gennaro
(L)
Patrizia Di Gregorio
(P)
Matteo Di Minno
(M)
Alfredo Dragani
(A)
Cosimo Pietro Ettorre
(C)
Massimo Franchini
(M)
Massimo Galli
(M)
Giovanni Gallo
(G)
Paola Giordano
(P)
Gaetano Giuffrida
(G)
Piergiorgio Iannaccaro
(P)
Giuseppe Lassandro
(G)
Ilaria Lazzareschi
(I)
Silvia Linari
(S)
Matteo Luciani
(M)
Silvia Macchi
(S)
Giuseppe Malcangi
(G)
Raniero Malizia
(R)
Marco Marietta
(M)
Renato Marino
(R)
Michela Massoud
(M)
Maria Gabriella Mazzucconi
(M)
Marta Milan
(M)
Massimo Morfini
(M)
Mariasanta Napolitano
(M)
Samantha Pasca
(S)
Paola Pedrazzi
(P)
Flora A Peyvandi
(FA)
Lydia Piscitelli
(L)
Berardino Pollio
(B)
Paola Preti
(P)
Gabriele Quintavalle
(G)
Paolo Radossi
(P)
Simona Raso
(S)
Irene Ricca
(I)
Angiola Rocino
(A)
Cristina Santoro
(C)
Rita Carlotta Santoro
(R)
Lucia Sarolo
(L)
Mario Schiavoni
(M)
Michele Schiavulli
(M)
Patrizia Sciancalepore
(P)
Maria Luisa Serino
(M)
Sergio Mario Siragusa
(S)
Gianluca Sottilotta
(G)
Johanna Svahn
(J)
Lelia Valdrè
(L)
Maria Cristina Vedovati
(M)
Ezio Zanon
(E)
Informations de copyright
© 2019 The Authors. Haemophilia Published by John Wiley & Sons Ltd.
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