γ-Catenin-Dependent Signals Maintain BCR-ABL1

Animals Fusion Proteins, bcr-abl / genetics Gene Expression Regulation, Leukemic Humans K562 Cells Mice, Inbred NOD Mice, SCID Mice, Transgenic Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / genetics Proto-Oncogene Proteins c-myc / genetics Survivin / genetics Wnt Signaling Pathway beta Catenin / genetics gamma Catenin / genetics
B cell acute lymphoblastic leukemia (B-ALL) BCR-ABL1 BIRC5 (Survivin) MYC chronic myeloid leukemia (CML) junction plakoglobin β-catenin γ-catenin

Journal

Cancer cell
ISSN: 1878-3686
Titre abrégé: Cancer Cell
Pays: United States
ID NLM: 101130617

Informations de publication

Date de publication:
15 04 2019
Historique:
received: 30 10 2015
revised: 29 01 2019
accepted: 14 03 2019
entrez: 17 4 2019
pubmed: 17 4 2019
medline: 6 2 2020
Statut: ppublish

Résumé

The BCR-ABL1 fusion protein is the cause of chronic myeloid leukemia (CML) and of a significant fraction of adult-onset B cell acute lymphoblastic leukemia (B-ALL) cases. Using mouse models and patient-derived samples, we identified an essential role for γ-catenin in the initiation and maintenance of BCR-ABL1

Identifiants

DOI: 10.1016/j.ccell.2019.03.005 PMID: 30991025
pubmed: 30991025
pii: S1535-6108(19)30150-3
doi: 10.1016/j.ccell.2019.03.005
pii:
doi:

Substances chimiques

BCR-ABL1 fusion protein, human 0
BIRC5 protein, human 0
Birc5 protein, mouse 0
CTNNB1 protein, human 0
CTNNB1 protein, mouse 0
JUP protein, human 0
Jup protein, mouse 0
MYC protein, human 0
Myc protein, mouse 0
Proto-Oncogene Proteins c-myc 0
Survivin 0
beta Catenin 0
gamma Catenin 0
Fusion Proteins, bcr-abl EC 2.7.10.2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

649-663.e10

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Noemie Luong-Gardiol (N)

Department of Oncology UNIL CHUV, University of Lausanne, Epalinges, Switzerland.

Imran Siddiqui (I)

Department of Oncology UNIL CHUV, University of Lausanne, Epalinges, Switzerland.

Irene Pizzitola (I)

Department of Oncology UNIL CHUV, University of Lausanne, Epalinges, Switzerland.

Beena Jeevan-Raj (B)

Department of Oncology UNIL CHUV, University of Lausanne, Epalinges, Switzerland.

Mélanie Charmoy (M)

Department of Oncology UNIL CHUV, University of Lausanne, Epalinges, Switzerland.

Yun Huang (Y)

Department of Pediatric Oncology and Children's Research Centre, University Children's Hospital Zürich, Zürich, Switzerland.

Anja Irmisch (A)

Swiss Institute for Experimental Cancer Research (ISREC), Federal University of Technology Lausanne (EPFL), Lausanne, Switzerland.

Sara Curtet (S)

Department of Oncology UNIL CHUV, University of Lausanne, Epalinges, Switzerland.

Georgi S Angelov (GS)

Department of Oncology UNIL CHUV, University of Lausanne, Epalinges, Switzerland.

Maxime Danilo (M)

Department of Oncology UNIL CHUV, University of Lausanne, Epalinges, Switzerland.

Mélanie Juilland (M)

Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.

Beat Bornhauser (B)

Department of Pediatric Oncology and Children's Research Centre, University Children's Hospital Zürich, Zürich, Switzerland.

Margot Thome (M)

Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.

Oliver Hantschel (O)

Swiss Institute for Experimental Cancer Research (ISREC), Federal University of Technology Lausanne (EPFL), Lausanne, Switzerland.

Yves Chalandon (Y)

Service d'Hématologie, Hôpitaux Universitaire de Genève, Geneva, Switzerland.

Gianni Cazzaniga (G)

Centro Ricerca Tettamanti, Pediatric Clinic University of Milano-Bicocca, Monza, Italy.

Jean-Pierre Bourquin (JP)

Department of Pediatric Oncology and Children's Research Centre, University Children's Hospital Zürich, Zürich, Switzerland.

Joerg Huelsken (J)

Swiss Institute for Experimental Cancer Research (ISREC), Federal University of Technology Lausanne (EPFL), Lausanne, Switzerland.

Werner Held (W)

Department of Oncology UNIL CHUV, University of Lausanne, Epalinges, Switzerland. Electronic address: werner.held@unil.ch.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › γ-Catenin-Dependent Signals Maintain BCR-ABL1
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-bcr › Protéines de fusion bcr-abl › γ-Catenin-Dependent Signals Maintain BCR-ABL1
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Régulation de l'expression des gènes dans la leucémie › γ-Catenin-Dependent Signals Maintain BCR-ABL1
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › γ-Catenin-Dependent Signals Maintain BCR-ABL1
questionsmedicales.fr › Cellules › Cellules érythroïdes › Cellules K562 › γ-Catenin-Dependent Signals Maintain BCR-ABL1
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée NOD › γ-Catenin-Dependent Signals Maintain BCR-ABL1
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris SCID › γ-Catenin-Dependent Signals Maintain BCR-ABL1
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › γ-Catenin-Dependent Signals Maintain BCR-ABL1
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Leucémie lymphoïde › Leucémie-lymphome lymphoblastique à précurseurs B et T › Leucémie-lymphome lymphoblastique à précurseurs B › γ-Catenin-Dependent Signals Maintain BCR-ABL1
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique hélice-boucle-hélice › Protéines proto-oncogènes c-myc › γ-Catenin-Dependent Signals Maintain BCR-ABL1
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Protéines IAP › Survivine › γ-Catenin-Dependent Signals Maintain BCR-ABL1
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Voie de signalisation Wnt › γ-Catenin-Dependent Signals Maintain BCR-ABL1
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › bêta-Caténine › γ-Catenin-Dependent Signals Maintain BCR-ABL1
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Caténines › gamma-Caténine › γ-Catenin-Dependent Signals Maintain BCR-ABL1