CD89 Is a Potent Innate Receptor for Bacteria and Mediates Host Protection from Sepsis.
Animals
Antigens, CD
/ genetics
C-Reactive Protein
/ metabolism
Cytokines
/ metabolism
Dendritic Cells
/ cytology
Disease Models, Animal
Escherichia coli
/ physiology
Female
Humans
Immunocompromised Host
Immunoglobulin A
/ blood
Kaplan-Meier Estimate
Mice
Mice, Inbred C57BL
Mice, Transgenic
Monocytes
/ cytology
Phagocytosis
Pneumonia
/ mortality
Receptors, Fc
/ genetics
Sepsis
/ immunology
Streptococcus pneumoniae
/ physiology
Fc receptor
ITAM
host defense
innate receptor
sepsis
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
16 04 2019
16 04 2019
Historique:
received:
29
05
2018
revised:
11
01
2019
accepted:
15
03
2019
entrez:
18
4
2019
pubmed:
18
4
2019
medline:
17
6
2020
Statut:
ppublish
Résumé
Direct bacterial recognition by innate receptors is crucial for bacterial clearance. Here, we show that the IgA receptor CD89 is a major innate receptor that directly binds bacteria independently of its cognate ligands IgA and c-reactive protein (CRP). This binding is only partially inhibited by serum IgA and induces bacterial phagocytosis by CD11c
Identifiants
pubmed: 30995475
pii: S2211-1247(19)30392-4
doi: 10.1016/j.celrep.2019.03.062
pii:
doi:
Substances chimiques
Antigens, CD
0
Cytokines
0
Fc(alpha) receptor
0
Immunoglobulin A
0
Receptors, Fc
0
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
762-775.e5Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.