An X-ray Vision for Phosphoantigen Recognition.

Antigens, CD Butyrophilins Lymphocyte Activation T-Lymphocytes / immunology X-Rays

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
16 04 2019
Historique:
entrez: 18 4 2019
pubmed: 18 4 2019
medline: 5 9 2019
Statut: ppublish

Résumé

Invariant Vγ9Vδ2 T cells respond to "phosphoantigen" metabolites through binding to the B30.2 domain of butyrophilin BTN3A. Yang et al. (2019) use molecular dynamic simulations based on X-ray structures of distinct B30.2 domain dimers to identify the asymmetric dimer as most active, which has implications for the inside-out signaling mechanism.

Identifiants

DOI: 10.1016/j.immuni.2019.03.015 PMID: 30995494
pubmed: 30995494
pii: S1074-7613(19)30132-3
doi: 10.1016/j.immuni.2019.03.015
pii:
doi:

Substances chimiques

Antigens, CD 0
Butyrophilins 0

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

1026-1028

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Michael L Dustin (ML)

Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK. Electronic address: michael.dustin@kennedy.ox.ac.uk.

Emmanuel Scotet (E)

CRCINA, INSERM, CNRS, Université d'Angers, Université de Nantes, Nantes, France.

Daniel Olive (D)

CRCM, Immunity and Cancer Team, Institut Paoli-Calmettes, INSERM, CNRS, Aix Marseille Université, Marseille, France.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes CD › An X-ray Vision for Phosphoantigen Recognition.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › Butyrophilines › An X-ray Vision for Phosphoantigen Recognition.
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › An X-ray Vision for Phosphoantigen Recognition.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › An X-ray Vision for Phosphoantigen Recognition.
questionsmedicales.fr › Phénomènes physiques › Rayonnement › Rayonnement ionisant › Rayons X › An X-ray Vision for Phosphoantigen Recognition.