Self-assembling Releasable Thiocolchicine-Diphenylbutenylaniline Conjugates.
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
11 Apr 2019
11 Apr 2019
Historique:
received:
30
11
2018
accepted:
31
12
2018
entrez:
19
4
2019
pubmed:
19
4
2019
medline:
19
4
2019
Statut:
epublish
Résumé
The design and the synthesis of new self-assembling conjugates is reported. The target compounds are characterized by the presence of a self-immolative linker that secures a controlled release induced by lipase cleavage. 4-(1,2-Diphenylbut-1-en-1-yl)aniline is used as a self-assembling inducer and amino-thiocolchicine as prototype of drug. The release of thiocolchicine derivative has been demonstrated
Identifiants
pubmed: 30996805
doi: 10.1021/acsmedchemlett.8b00605
pmc: PMC6466830
doi:
Types de publication
Journal Article
Langues
eng
Pagination
611-614Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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