Pierfausto Seneci

Affiliations

Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, Milano 20133, Italy.

Publications (29)

Stimulus-responsive liposomes for biomedical applications.

Drug discovery today

Avec: Antonia I Antoniou , Sabrina Giofrè , Pierfausto Seneci , Daniele Passarella , Sara Pellegrino

Novel, soluble 3-heteroaryl-substituted tanshinone mimics attenuate the inflammatory response in murine macrophages.

Scientific reports

Avec: Elisa Facen , Giulia Assoni , Greta Donati , Dalila Paladino , Agata Carreira , Isabelle Bonomo , Valeria La Pietra , Roberta Lotti , Josef Houser , Luca L Fava , Pierfausto Seneci , Luciana Marinelli , Daniela Arosio , Alessandro Provenzani

Identification of Isoform 2 Acid-Sensing Ion Channel Inhibitors as Tool Compounds for Target Validation Studies in CNS.

ACS medicinal chemistry letters

Avec: Leda Ivanova Bencheva , Marilenia De Matteo , Luca Ferrante , Marco Ferrara , Adolfo Prandi , Pietro Randazzo , Silvano Ronzoni , Roberta Sinisi , Pierfausto Seneci , Vincenzo Summa , Mariana Gallo , Maria Veneziano , Antonella Cellucci , Nausicaa Mazzocchi , Andrea Menegon , Romano Di Fabio

Intracisternal delivery of PEG-coated gold nanoparticles results in high brain penetrance and long-lasting stability.

Journal of nanobiotechnology

Avec: Antonello Spinelli , Maria Girelli , Daniela Arosio , Laura Polito , Paola Podini , Gianvito Martino , Pierfausto Seneci , Luca Muzio , Andrea Menegon

Trehalose-based neuroprotective autophagy inducers.

Bioorganic & medicinal chemistry letters

Avec: Giulia Assoni , Giulia Frapporti , Eleonora Colombo , Davide Gornati , Maria Dolores Perez-Carrion , Laura Polito , Pierfausto Seneci , Giovanni Piccoli , Daniela Arosio

Synthesis and Characterization of Novel Mono- and Bis-Guanyl Hydrazones as Potent and Selective ASIC1 Inhibitors Able to Reduce Brain Ischemic Insult.

Journal of medicinal chemistry

Avec: Davide Gornati , Roselia Ciccone , Antonio Vinciguerra , Stefania Ippati , Anna Pannaccione , Tiziana Petrozziello , Erika Pizzi , Amal Hassan , Eleonora Colombo , Stefano Barbini , Mario Milani , Cecilia Caccavone , Pietro Randazzo , Luca Muzio , Lucio Annunziato , Andrea Menegon , Agnese Secondo , Eloise Mastrangelo , Giuseppe Pignataro , Pierfausto Seneci

A novel, glutathione-activated prodrug of pimasertib loaded in liposomes for targeted cancer therapy.

RSC medicinal chemistry

Avec: Arianna Amenta , Susanna Comi , Marcelo Kravicz , Silvia Sesana , Antonia Antoniou , Daniele Passarella , Pierfausto Seneci , Sara Pellegrino , Francesca Re

Detecting drugs in dry bone: a pilot study of skeletal remains with a post-mortem interval over 23 years.

International journal of legal medicine

Avec: Gaia Giordano , Lucie Biehler-Gomez , Pierfausto Seneci , Cristina Cattaneo , Domenico Di Candia

Nanolipid-Trehalose Conjugates and Nano-Assemblies as Putative Autophagy Inducers.

Pharmaceutics

Avec: Eleonora Colombo , Michele Biocotino , Giulia Frapporti , Pietro Randazzo , Michael S Christodoulou , Giovanni Piccoli , Laura Polito , Pierfausto Seneci , Daniele Passarella

HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis.

The Journal of clinical investigation

Avec: Marta Palomo-Irigoyen , Encarni Pérez-Andrés , Marta Iruarrizaga-Lejarreta , Adrián Barreira-Manrique , Miguel Tamayo-Caro , Laura Vila-Vecilla , Leire Moreno-Cugnon , Nagore Beitia , Daniela Medrano , David Fernández-Ramos , Juan José Lozano , Satoshi Okawa , José L Lavín , Natalia Martín-Martín , James D Sutherland , Virginia Guitiérez de Juan , Monika Gonzalez-Lopez , Nuria Macías-Cámara , David Mosén-Ansorena , Liyam Laraba , C Oliver Hanemann , Emanuela Ercolano , David B Parkinson , Christopher W Schultz , Marcos J Araúzo-Bravo , Alex M Ascensión , Daniela Gerovska , Haizea Iribar , Ander Izeta , Peter Pytel , Philipp Krastel , Alessandro Provenzani , Pierfausto Seneci , Ruben D Carrasco , Antonio Del Sol , María Luz Martinez-Chantar , Rosa Barrio , Eduard Serra , Conxi Lazaro , Adrienne M Flanagan , Myriam Gorospe , Nancy Ratner , Ana M Aransay , Arkaitz Carracedo , Marta Varela-Rey , Ashwin Woodhoo

HuR-targeted agents: An insight into medicinal chemistry, biophysical, computational studies and pharmacological effects on cancer models.

Advanced drug delivery reviews

Avec: Giulia Assoni , Valeria La Pietra , Rosangela Digilio , Caterina Ciani , Nausicaa Valentina Licata , Mariachiara Micaelli , Elisa Facen , Weronika Tomaszewska , Linda Cerofolini , Anna Pérez-Ràfols , Marta Varela Rey , Marco Fragai , Ashwin Woodhoo , Luciana Marinelli , Daniela Arosio , Isabelle Bonomo , Alessandro Provenzani , Pierfausto Seneci

Raman Spectroscopy Characterization of Multi-Functionalized Liposomes as Drug-Delivery Systems for Neurological Disorders.

Nanomaterials (Basel, Switzerland)

Avec: Francesca Rodà , Silvia Picciolini , Valentina Mangolini , Alice Gualerzi , Pierfausto Seneci , Antonio Renda , Silvia Sesana , Francesca Re , Marzia Bedoni

Glibenclamide-Loaded Engineered Nanovectors (GNVs) Modulate Autophagy and NLRP3-Inflammasome Activation.

Pharmaceuticals (Basel, Switzerland)

Avec: Marina Saresella , Chiara Paola Zoia , Francesca La Rosa , Chiara Bazzini , Gessica Sala , Erica Grassenis , Ivana Marventano , Ambra Hernis , Federica Piancone , Elisa Conti , Silvia Sesana , Francesca Re , Pierfausto Seneci , Carlo Ferrarese , Mario Clerici

Stabilization of the retromer complex: Analysis of novel binding sites of bis-1,3-phenyl guanylhydrazone 2a to the VPS29/VPS35 interface.

Computational and structural biotechnology journal

Avec: Elisa Fagnani , Francesco Bonì , Pierfausto Seneci , Davide Gornati , Luca Muzio , Eloise Mastrangelo , Mario Milani

Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis.

Nature communications

Avec: Luca Muzio , Riccardo Sirtori , Davide Gornati , Simona Eleuteri , Andrea Fossaghi , Diego Brancaccio , Leonardo Manzoni , Linda Ottoboni , Luca De Feo , Angelo Quattrini , Eloise Mastrangelo , Luca Sorrentino , Emanuele Scalone , Giancarlo Comi , Luciana Marinelli , Nilo Riva , Mario Milani , Pierfausto Seneci , Gianvito Martino

Squalene-Based Nano-Assemblies Improve the Pro-Autophagic Activity of Trehalose.

Pharmaceutics

Avec: Giulia Frapporti , Eleonora Colombo , Hazem Ahmed , Giulia Assoni , Laura Polito , Pietro Randazzo , Daniela Arosio , Pierfausto Seneci , Giovanni Piccoli

Dual Functionalized Liposomes for Selective Delivery of Poorly Soluble Drugs to Inflamed Brain Regions.

Pharmaceutics

Avec: Sabrina Giofrè , Antonio Renda , Silvia Sesana , Beatrice Formicola , Barbara Vergani , Biagio Eugenio Leone , Vanna Denti , Giuseppe Paglia , Serena Groppuso , Valentina Romeo , Luca Muzio , Andrea Balboni , Andrea Menegon , Antonia Antoniou , Arianna Amenta , Daniele Passarella , Pierfausto Seneci , Sara Pellegrino , Francesca Re

SPRi analysis of molecular interactions of mApoE-functionalized liposomes as drug delivery systems for brain diseases.

The Analyst

Avec: Silvia Picciolini , Francesca Rodà , Alice Gualerzi , Valentina Mangolini , Luana Forleo , Aurora Mangolini , Silvia Sesana , Antonia Antoniou , Francesca Re , Pierfausto Seneci , Marzia Bedoni

Synthesis and Preliminary Characterization of Putative Anle138b-Centered PROTACs against α-Synuclein Aggregation.

Pharmaceutics

Avec: Martina Pedrini , Angelo Iannielli , Lorenzo Meneghelli , Daniele Passarella , Vania Broccoli , Pierfausto Seneci

Theoretical and experimental studies on the interaction of biphenyl ligands with human and murine PD-L1: Up-to-date clues for drug design.

Computational and structural biotechnology journal

Avec: Greta Donati , Vincenzo Maria D'Amore , Pasquale Russomanno , Linda Cerofolini , Jussara Amato , Simona Marzano , Maria Salobehaj , Domenico Rizzo , Giulia Assoni , Alfonso Carotenuto , Valeria La Pietra , Daniela Arosio , Pierfausto Seneci , Marco Fragai , Diego Brancaccio , Francesco Saverio Di Leva , Luciana Marinelli

Glibenclamide-Loaded Nanoparticles Reduce NLRP3 Inflammasome Activation and Modulate miR-223-3p/miR-7-1-5p Expression in THP-1 Cells.

Pharmaceuticals (Basel, Switzerland)

Avec: Roberta Mancuso , Lorenzo Agostino Citterio , Simone Agostini , Ivana Marventano , Francesca La Rosa , Francesca Re , Pierfausto Seneci , Marina Saresella , Mario Clerici

Self-assembling Releasable Thiocolchicine-Diphenylbutenylaniline Conjugates.

ACS medicinal chemistry letters

Avec: Gaia Fumagalli , Laura Polito , Eleonora Colombo , Francesca Foschi , Michael S Christodoulou , Francesco Galeotti , Dario Perdicchia , Ivan Bassanini , Sergio Riva , Pierfausto Seneci , Aída García-Argáez , Lisa Dalla Via , Daniele Passarella

Interfering with the Tumor-Immune Interface: Making Way for Triazine-Based Small Molecules as Novel PD-L1 Inhibitors.

Journal of medicinal chemistry

Avec: Pasquale Russomanno , Giulia Assoni , Jussara Amato , Vincenzo Maria D'Amore , Riccardo Scaglia , Diego Brancaccio , Martina Pedrini , Giovanna Polcaro , Valeria La Pietra , Paolo Orlando , Marianna Falzoni , Linda Cerofolini , Stefano Giuntini , Marco Fragai , Bruno Pagano , Greta Donati , Ettore Novellino , Cristina Quintavalle , Gerolama Condorelli , Francesco Sabbatino , Pierfausto Seneci , Daniela Arosio , Stefano Pepe , Luciana Marinelli

A combined approach of structure-based virtual screening and NMR to interrupt the PD-1/PD-L1 axis: Biphenyl-benzimidazole containing compounds as novel PD-L1 inhibitors.

Archiv der Pharmazie

Avec: Greta Donati , Monica Viviano , Vincenzo Maria D'Amore , Alessandra Cipriano , Isidora Diakogiannaki , Jussara Amato , Stefano Tomassi , Diego Brancaccio , Pasquale Russomanno , Francesco Saverio Di Leva , Daniela Arosio , Pierfausto Seneci , Sabrina Taliani , Katarzyna Magiera-Mularz , Bogdan Musielak , Lukasz Skalniak , Tad A Holak , Sabrina Castellano , Valeria La Pietra , Luciana Marinelli

Folic acid functionalization for targeting self-assembled paclitaxel-based nanoparticles.

RSC advances

Avec: Eleonora Colombo , Davide Andrea Coppini , Simone Maculan , Pierfausto Seneci , Benedetta Santini , Filippo Testa , Lucia Salvioni , Giovanni Maria Vanacore , Miriam Colombo , Daniele Passarella

HuR modulation counteracts lipopolysaccharide response in murine macrophages.

Disease models & mechanisms

Avec: Isabelle Bonomo , Giulia Assoni , Valeria La Pietra , Giulia Canarutto , Elisa Facen , Greta Donati , Chiara Zucal , Silvia Genovese , Mariachiara Micaelli , Anna Pérez-Ràfols , Sergio Robbiati , Dimitris L Kontoyannis , Marilenia De Matteo , Marco Fragai , Pierfausto Seneci , Luciana Marinelli , Daniela Arosio , Silvano Piazza , Alessandro Provenzani

2-Hydroxyoleic Acid as a Self-Assembly Inducer for Anti-Cancer Drug-Centered Nanoparticles.

Pharmaceuticals (Basel, Switzerland)

Avec: Antonia I Antoniou , Giulia Nordio , Maria Luisa Di Paolo , Eleonora Colombo , Beatrice Gaffuri , Laura Polito , Arianna Amenta , Pierfausto Seneci , Lisa Dalla Via , Dario Perdicchia , Daniele Passarella

Synthesis and Characterization of Edaravone Analogues as Remyelinating Agents and Putative Mechanistic Probes.

Molecules (Basel, Switzerland)

Avec: Eleonora Colombo , Stefania Olla , Cristina Minnelli , Alessia Formato , Caterina Veroni , Silvia Corbisiero , Mattia Pericolo , Chiara Siguri , Giovanna Mobbili , Cristina Agresti , Pierfausto Seneci

Acid-sensing ion channel 3 is a new potential therapeutic target for the control of glioblastoma cancer stem cells growth.

Scientific reports

Avec: Andrea Balboni , Camilla D'Angelo , Nicoletta Collura , Simone Brusco , Claudia Di Berardino , Altea Targa , Beatrice Massoti , Eloise Mastrangelo , Mario Milani , Pierfausto Seneci , Vania Broccoli , Luca Muzio , Rossella Galli , Andrea Menegon

Réseau de co-auteurs

Daniela Arosio 9 collaborations

Daniele Passarella 8 collaborations

Eleonora Colombo 8 collaborations

Giulia Assoni 7 collaborations

Luciana Marinelli 7 collaborations

Valeria La Pietra 6 collaborations

Laura Polito 6 collaborations

Luca Muzio 6 collaborations

Francesca Re 6 collaborations

Greta Donati 5 collaborations

Andrea Menegon 5 collaborations

Silvia Sesana 5 collaborations

Alessandro Provenzani 4 collaborations

Pietro Randazzo 4 collaborations

Davide Gornati 4 collaborations

Mario Milani 4 collaborations

Eloise Mastrangelo 4 collaborations

Marco Fragai 4 collaborations

Diego Brancaccio 4 collaborations

Sara Pellegrino 3 collaborations

Elisa Facen 3 collaborations

Isabelle Bonomo 3 collaborations

Giulia Frapporti 3 collaborations

Giovanni Piccoli 3 collaborations

Arianna Amenta 3 collaborations

Antonia Antoniou 3 collaborations

Linda Cerofolini 3 collaborations

Vincenzo Maria D'Amore 3 collaborations

Pasquale Russomanno 3 collaborations

Jussara Amato 3 collaborations

Antonia I Antoniou 2 collaborations

Sabrina Giofrè 2 collaborations

Marilenia De Matteo 2 collaborations

Gianvito Martino 2 collaborations

Michael S Christodoulou 2 collaborations

Ashwin Woodhoo 2 collaborations

Mariachiara Micaelli 2 collaborations

Anna Pérez-Ràfols 2 collaborations

Francesca Rodà 2 collaborations

Silvia Picciolini 2 collaborations

Valentina Mangolini 2 collaborations

Alice Gualerzi 2 collaborations

Antonio Renda 2 collaborations

Marzia Bedoni 2 collaborations

Marina Saresella 2 collaborations

Francesca La Rosa 2 collaborations

Ivana Marventano 2 collaborations

Mario Clerici 2 collaborations

Andrea Balboni 2 collaborations

Martina Pedrini 2 collaborations

Vania Broccoli 2 collaborations

Francesco Saverio Di Leva 2 collaborations

Dario Perdicchia 2 collaborations

Lisa Dalla Via 2 collaborations

Dalila Paladino 1 collaboration

Agata Carreira 1 collaboration

Roberta Lotti 1 collaboration

Josef Houser 1 collaboration

Luca L Fava 1 collaboration

Leda Ivanova Bencheva 1 collaboration

Luca Ferrante 1 collaboration

Marco Ferrara 1 collaboration

Adolfo Prandi 1 collaboration

Silvano Ronzoni 1 collaboration

Roberta Sinisi 1 collaboration

Vincenzo Summa 1 collaboration

Mariana Gallo 1 collaboration

Maria Veneziano 1 collaboration

Antonella Cellucci 1 collaboration

Nausicaa Mazzocchi 1 collaboration

Romano Di Fabio 1 collaboration

Antonello Spinelli 1 collaboration

Maria Girelli 1 collaboration

Paola Podini 1 collaboration

Maria Dolores Perez-Carrion 1 collaboration

Roselia Ciccone 1 collaboration

Antonio Vinciguerra 1 collaboration

Stefania Ippati 1 collaboration

Anna Pannaccione 1 collaboration

Tiziana Petrozziello 1 collaboration

Erika Pizzi 1 collaboration

Amal Hassan 1 collaboration

Stefano Barbini 1 collaboration

Cecilia Caccavone 1 collaboration

Lucio Annunziato 1 collaboration

Agnese Secondo 1 collaboration

Giuseppe Pignataro 1 collaboration

Susanna Comi 1 collaboration

Marcelo Kravicz 1 collaboration

Gaia Giordano 1 collaboration

Lucie Biehler-Gomez 1 collaboration

Cristina Cattaneo 1 collaboration

Domenico Di Candia 1 collaboration

Michele Biocotino 1 collaboration

Marta Palomo-Irigoyen 1 collaboration

Encarni Pérez-Andrés 1 collaboration

Marta Iruarrizaga-Lejarreta 1 collaboration

Adrián Barreira-Manrique 1 collaboration

Miguel Tamayo-Caro 1 collaboration

Laura Vila-Vecilla 1 collaboration

Leire Moreno-Cugnon 1 collaboration

Nagore Beitia 1 collaboration

Daniela Medrano 1 collaboration

David Fernández-Ramos 1 collaboration

Juan José Lozano 1 collaboration

Satoshi Okawa 1 collaboration

José L Lavín 1 collaboration

Natalia Martín-Martín 1 collaboration

James D Sutherland 1 collaboration

Virginia Guitiérez de Juan 1 collaboration

Monika Gonzalez-Lopez 1 collaboration

Nuria Macías-Cámara 1 collaboration

David Mosén-Ansorena 1 collaboration

Liyam Laraba 1 collaboration

C Oliver Hanemann 1 collaboration

Emanuela Ercolano 1 collaboration

David B Parkinson 1 collaboration

Christopher W Schultz 1 collaboration

Marcos J Araúzo-Bravo 1 collaboration

Alex M Ascensión 1 collaboration

Daniela Gerovska 1 collaboration

Haizea Iribar 1 collaboration

Ander Izeta 1 collaboration

Peter Pytel 1 collaboration

Philipp Krastel 1 collaboration

Ruben D Carrasco 1 collaboration

Antonio Del Sol 1 collaboration

María Luz Martinez-Chantar 1 collaboration

Rosa Barrio 1 collaboration

Eduard Serra 1 collaboration

Conxi Lazaro 1 collaboration

Adrienne M Flanagan 1 collaboration

Myriam Gorospe 1 collaboration

Nancy Ratner 1 collaboration

Ana M Aransay 1 collaboration

Arkaitz Carracedo 1 collaboration

Marta Varela-Rey 1 collaboration

Rosangela Digilio 1 collaboration

Caterina Ciani 1 collaboration

Nausicaa Valentina Licata 1 collaboration

Weronika Tomaszewska 1 collaboration

Marta Varela Rey 1 collaboration

Chiara Paola Zoia 1 collaboration

Chiara Bazzini 1 collaboration

Gessica Sala 1 collaboration

Erica Grassenis 1 collaboration

Ambra Hernis 1 collaboration

Federica Piancone 1 collaboration

Elisa Conti 1 collaboration

Carlo Ferrarese 1 collaboration

Elisa Fagnani 1 collaboration

Francesco Bonì 1 collaboration

Riccardo Sirtori 1 collaboration

Simona Eleuteri 1 collaboration

Andrea Fossaghi 1 collaboration

Leonardo Manzoni 1 collaboration

Linda Ottoboni 1 collaboration

Luca De Feo 1 collaboration

Angelo Quattrini 1 collaboration

Luca Sorrentino 1 collaboration

Emanuele Scalone 1 collaboration

Giancarlo Comi 1 collaboration

Nilo Riva 1 collaboration

Hazem Ahmed 1 collaboration

Beatrice Formicola 1 collaboration

Barbara Vergani 1 collaboration

Biagio Eugenio Leone 1 collaboration

Vanna Denti 1 collaboration

Giuseppe Paglia 1 collaboration

Serena Groppuso 1 collaboration

Valentina Romeo 1 collaboration

Luana Forleo 1 collaboration

Aurora Mangolini 1 collaboration

Angelo Iannielli 1 collaboration

Lorenzo Meneghelli 1 collaboration

Simona Marzano 1 collaboration

Maria Salobehaj 1 collaboration

Domenico Rizzo 1 collaboration

Alfonso Carotenuto 1 collaboration

Roberta Mancuso 1 collaboration

Lorenzo Agostino Citterio 1 collaboration

Simone Agostini 1 collaboration

Gaia Fumagalli 1 collaboration

Francesca Foschi 1 collaboration

Francesco Galeotti 1 collaboration

Ivan Bassanini 1 collaboration

Sergio Riva 1 collaboration

Aída García-Argáez 1 collaboration

Riccardo Scaglia 1 collaboration

Giovanna Polcaro 1 collaboration

Paolo Orlando 1 collaboration

Marianna Falzoni 1 collaboration

Stefano Giuntini 1 collaboration

Bruno Pagano 1 collaboration

Ettore Novellino 1 collaboration

Cristina Quintavalle 1 collaboration

Gerolama Condorelli 1 collaboration

Francesco Sabbatino 1 collaboration

Stefano Pepe 1 collaboration

Monica Viviano 1 collaboration

Alessandra Cipriano 1 collaboration

Isidora Diakogiannaki 1 collaboration

Stefano Tomassi 1 collaboration

Sabrina Taliani 1 collaboration

Katarzyna Magiera-Mularz 1 collaboration

Bogdan Musielak 1 collaboration

Lukasz Skalniak 1 collaboration

Tad A Holak 1 collaboration

Sabrina Castellano 1 collaboration

Davide Andrea Coppini 1 collaboration

Simone Maculan 1 collaboration

Benedetta Santini 1 collaboration

Filippo Testa 1 collaboration

Lucia Salvioni 1 collaboration

Giovanni Maria Vanacore 1 collaboration

Miriam Colombo 1 collaboration

Giulia Canarutto 1 collaboration

Chiara Zucal 1 collaboration

Silvia Genovese 1 collaboration

Sergio Robbiati 1 collaboration

Dimitris L Kontoyannis 1 collaboration

Silvano Piazza 1 collaboration

Giulia Nordio 1 collaboration

Maria Luisa Di Paolo 1 collaboration

Beatrice Gaffuri 1 collaboration

Stefania Olla 1 collaboration

Cristina Minnelli 1 collaboration

Alessia Formato 1 collaboration

Caterina Veroni 1 collaboration

Silvia Corbisiero 1 collaboration

Mattia Pericolo 1 collaboration

Chiara Siguri 1 collaboration

Giovanna Mobbili 1 collaboration

Cristina Agresti 1 collaboration

Camilla D'Angelo 1 collaboration

Nicoletta Collura 1 collaboration

Simone Brusco 1 collaboration

Claudia Di Berardino 1 collaboration

Altea Targa 1 collaboration

Beatrice Massoti 1 collaboration

Rossella Galli 1 collaboration