Stimulus-responsive liposomes for biomedical applications.
Active targeting
Cancer therapy
Enzyme-responsive liposomes
Hypoxia-responsive liposomes
Internal stimuli
Liposomes
Nanocarriers
Redox-responsive liposomes
Self-assembly
Targeted drug delivery
pH-responsive liposomes
Journal
Drug discovery today
ISSN: 1878-5832
Titre abrégé: Drug Discov Today
Pays: England
ID NLM: 9604391
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
30
11
2020
revised:
01
03
2021
accepted:
17
05
2021
pubmed:
1
6
2021
medline:
27
1
2022
entrez:
31
5
2021
Statut:
ppublish
Résumé
Liposomes are amphipathic lipidic supramolecular aggregates that are able to encapsulate and carry molecules of both hydrophilic and hydrophobic nature. They have been widely used as in vivo drug delivery systems for some time because they offer features such as synthetic flexibility, biodegradability, biocompatibility, low immunogenicity, and negligible toxicity. In recent years, the chemical modification of liposomes has paved the way to the development of smart liposome-based drug delivery systems, which are characterized by even more tunable and disease-directed features. In this review, we highlight the different types of chemical modification introduced to date, with a particular focus on internal stimuli-responsive liposomes and prodrug activation.
Identifiants
pubmed: 34058372
pii: S1359-6446(21)00243-9
doi: 10.1016/j.drudis.2021.05.010
pii:
doi:
Substances chimiques
Liposomes
0
Pharmaceutical Preparations
0
Prodrugs
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1794-1824Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.