Stabilization of the retromer complex: Analysis of novel binding sites of bis-1,3-phenyl guanylhydrazone 2a to the VPS29/VPS35 interface.
Crystal structure
Molecular dynamics simulations
Protein binding sites
Protein ligand interaction
Journal
Computational and structural biotechnology journal
ISSN: 2001-0370
Titre abrégé: Comput Struct Biotechnol J
Pays: Netherlands
ID NLM: 101585369
Informations de publication
Date de publication:
Dec 2024
Dec 2024
Historique:
received:
06
11
2023
revised:
27
02
2024
accepted:
27
02
2024
medline:
15
3
2024
pubmed:
15
3
2024
entrez:
15
3
2024
Statut:
epublish
Résumé
The stabilization of the retromer protein complex can be effective in the treatment of different neurological disorders. Following the identification of bis-1,3-phenyl guanylhydrazone
Identifiants
pubmed: 38487369
doi: 10.1016/j.csbj.2024.02.026
pii: S2001-0370(24)00050-3
pmc: PMC10937258
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1088-1093Informations de copyright
© 2024 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.