Synthesis and Characterization of Novel Mono- and Bis-Guanyl Hydrazones as Potent and Selective ASIC1 Inhibitors Able to Reduce Brain Ischemic Insult.
Acid Sensing Ion Channel Blockers
/ chemical synthesis
Acid Sensing Ion Channels
/ chemistry
Animals
Binding Sites
CHO Cells
Chickens
Cricetulus
Drug Design
Guanidines
/ chemical synthesis
HEK293 Cells
Humans
Hydrazones
/ chemical synthesis
Infarction, Middle Cerebral Artery
/ drug therapy
Mice
Molecular Docking Simulation
Molecular Structure
Neurons
/ drug effects
Neuroprotective Agents
/ chemical synthesis
Protein Binding
Rats
Structure-Activity Relationship
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
24 06 2021
24 06 2021
Historique:
pubmed:
8
6
2021
medline:
26
8
2021
entrez:
7
6
2021
Statut:
ppublish
Résumé
Acid-sensitive ion channels (ASICs) are sodium channels partially permeable to Ca
Identifiants
pubmed: 34097384
doi: 10.1021/acs.jmedchem.1c00305
doi:
Substances chimiques
ASIC1 protein, human
0
Acid Sensing Ion Channel Blockers
0
Acid Sensing Ion Channels
0
Guanidines
0
Hydrazones
0
Neuroprotective Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM