Ionophore-Based Biphasic Chemical Sensing in Droplet Microfluidics.

Ionophores / metabolism Microfluidic Analytical Techniques / methods Microfluidics / methods
analytical methods droplet microfluidics ionophores molecular recognition sensors

Journal

Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543

Informations de publication

Date de publication:
11 06 2019
Historique:
received: 08 03 2019
revised: 14 04 2019
pubmed: 19 4 2019
medline: 9 9 2020
entrez: 19 4 2019
Statut: ppublish

Résumé

Droplet microfluidics is an enabling platform for high-throughput screens, single-cell studies, low-volume chemical diagnostics, and microscale material syntheses. Analytical methods for real-time and in situ detection of chemicals in the droplets will benefit these applications, but they remain limited. Reported herein is a novel heterogeneous chemical sensing strategy based on functionalization of the oil phase with rationally combined sensing reagents. Sub-nanoliter oil segments containing pH-sensitive fluorophores, ionophores, and ion-exchangers enable highly selective and rapid fluorescence detection of physiologically important electrolytes (K

Identifiants

DOI: 10.1002/anie.201902960 PMID: 30997728
pubmed: 30997728
doi: 10.1002/anie.201902960
doi:

Substances chimiques

Ionophores 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

8092-8096

Subventions

Organisme : NIH HHS
ID : CA191186
Pays : United States
Organisme : University of Michigan
ID : ESSI-2018-6
Pays : International

Informations de copyright

© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Auteurs

Xuewei Wang (X)

Department of Chemistry, University of Michigan, 930 N University, Ann Arbor, MI, 48109, USA.
ORCID: 0000-0001-9604-3045

Meng Sun (M)

Department of Chemistry, University of Michigan, 930 N University, Ann Arbor, MI, 48109, USA.
Department of Biophysics, University of Michigan, 930 N University, Ann Arbor, MI, 48109, USA.

Stephen A Ferguson (SA)

Department of Chemistry, University of Michigan, 930 N University, Ann Arbor, MI, 48109, USA.

J Damon Hoff (JD)

Department of Biophysics, University of Michigan, 930 N University, Ann Arbor, MI, 48109, USA.

Yu Qin (Y)

Department of Chemistry, University of Michigan, 930 N University, Ann Arbor, MI, 48109, USA.

Ryan C Bailey (RC)

Department of Chemistry, University of Michigan, 930 N University, Ann Arbor, MI, 48109, USA.
ORCID: 0000-0003-1021-4267

Mark E Meyerhoff (ME)

Department of Chemistry, University of Michigan, 930 N University, Ann Arbor, MI, 48109, USA.
ORCID: 0000-0002-7841-281X

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Ionophores › Ionophore-Based Biphasic Chemical Sensing in...
questionsmedicales.fr › Techniques d'investigation › Procédures d'analyse sur micropuce › Techniques d'analyse microfluidique › Ionophore-Based Biphasic Chemical Sensing in...
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Miniaturisation › Microtechnologie › Microfluidique › Ionophore-Based Biphasic Chemical Sensing in...