The Association of ApoE ε4 Status with Lower Limb Function and Handgrip Strength in Older Adults.
Apolipoprotein
handgrip strength
lower limb function
Journal
The Journal of frailty & aging
ISSN: 2260-1341
Titre abrégé: J Frailty Aging
Pays: France
ID NLM: 101604797
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
19
4
2019
pubmed:
19
4
2019
medline:
30
6
2019
Statut:
ppublish
Résumé
Apolipoprotein (ApoE ε4) status has been associated with various cardiovascular diseases and Alzheimer's Disease. Some studies have found a possible relationship between the presence of an ApoE ε4 allele and the decrease of motor function in healthy older adults. The objective of this study was to measure the cross-sectional and prospective associations of ApoE ε4 status with lower limb function and handgrip strength in older adults. Longitudinal observational study using data from a randomized controlled trial. Community-dwelling older adults. 1300 older adults (≥70 years old) with ApoE ε4 status from the Multidomain Alzheimer's Preventive Trial (MAPT) were followed for three years. Lower-limb function was measured with the Short Physical Performance Battery (SPPB) and muscle strength was measured with a handgrip strength dynamometer. ApoE ε4 status was assessed with a blood draw. Mixed-effect linear regressions were used to examine cross-sectional as well as prospective associations between ApoE ε4 status and the outcomes. No significant cross-sectional or prospective associations were found between ApoE ε4 status, lower-limb function and handgrip strength in our study. ApoE ε4 status was not associated with motor function in older adults.
Sections du résumé
BACKGROUND/OBJECTIVES
OBJECTIVE
Apolipoprotein (ApoE ε4) status has been associated with various cardiovascular diseases and Alzheimer's Disease. Some studies have found a possible relationship between the presence of an ApoE ε4 allele and the decrease of motor function in healthy older adults. The objective of this study was to measure the cross-sectional and prospective associations of ApoE ε4 status with lower limb function and handgrip strength in older adults.
DESIGN
METHODS
Longitudinal observational study using data from a randomized controlled trial.
SETTING
METHODS
Community-dwelling older adults.
PARTICIPANTS
METHODS
1300 older adults (≥70 years old) with ApoE ε4 status from the Multidomain Alzheimer's Preventive Trial (MAPT) were followed for three years.
MEASUREMENTS
METHODS
Lower-limb function was measured with the Short Physical Performance Battery (SPPB) and muscle strength was measured with a handgrip strength dynamometer. ApoE ε4 status was assessed with a blood draw. Mixed-effect linear regressions were used to examine cross-sectional as well as prospective associations between ApoE ε4 status and the outcomes.
RESULTS
RESULTS
No significant cross-sectional or prospective associations were found between ApoE ε4 status, lower-limb function and handgrip strength in our study.
CONCLUSIONS
CONCLUSIONS
ApoE ε4 status was not associated with motor function in older adults.
Substances chimiques
Apolipoprotein E4
0
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
62-66Déclaration de conflit d'intérêts
The authors disclose no conflict of interests.