Unveiling the Efficacy, Safety, and Tolerability of Anti-Interleukin-1 Treatment in Monogenic and Multifactorial Autoinflammatory Diseases.
Animals
Antibodies, Monoclonal
/ adverse effects
Antibodies, Monoclonal, Humanized
Arthritis, Juvenile
/ drug therapy
Cryopyrin-Associated Periodic Syndromes
/ drug therapy
Familial Mediterranean Fever
/ drug therapy
Fever
/ drug therapy
Hereditary Autoinflammatory Diseases
/ drug therapy
Humans
Interleukin 1 Receptor Antagonist Protein
/ adverse effects
Interleukin-1beta
/ immunology
Mevalonate Kinase Deficiency
/ drug therapy
Mucocutaneous Lymph Node Syndrome
/ drug therapy
Receptors, Interleukin-1
/ antagonists & inhibitors
Interleukin-1
Kawasaki disease
anakinra
autoinflammatory disease
canakinumab
child
innovative biotechnologies
pediatrics
personalized medicine
systemic juvenile idiopathic arthritis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 Apr 2019
17 Apr 2019
Historique:
received:
25
03
2019
revised:
13
04
2019
accepted:
15
04
2019
entrez:
20
4
2019
pubmed:
20
4
2019
medline:
17
8
2019
Statut:
epublish
Résumé
Autoinflammatory diseases (AIDs) are heterogeneous disorders characterized by dysregulation in the inflammasome, a large intracellular multiprotein platform, leading to overproduction of interleukin-1(IL-1)β that plays a predominant pathogenic role in such diseases. Appropriate treatment is crucial, also considering that AIDs may persist into adulthood with negative consequences on patients' quality of life. IL-1β blockade results in a sustained reduction of disease severity in most AIDs. A growing experience with the human IL-1 receptor antagonist, Anakinra (ANA), and the monoclonal anti IL-1β antibody, Canakinumab (CANA), has also been engendered, highlighting their efficacy upon protean clinical manifestations of AIDs. Safety and tolerability have been confirmed by several clinical trials and observational studies on both large and small cohorts of AID patients. The same treatment has been proposed in refractory Kawasaki disease, an acute inflammatory vasculitis occurring in children before 5 years, which has been postulated to be autoinflammatory for its phenotypical and immunological similarity with systemic juvenile idiopathic arthritis. Nevertheless, minor concerns about IL-1 antagonists have been raised regarding their employment in children, and the development of novel pharmacological formulations is aimed at minimizing side effects that may affect adherence to treatment. The present review summarizes current findings on the efficacy, safety, and tolerability of ANA and CANA for treatment of AIDs and Kawasaki vasculitis with a specific focus on the pediatric setting.
Identifiants
pubmed: 30999610
pii: ijms20081898
doi: 10.3390/ijms20081898
pmc: PMC6514653
pii:
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antibodies, Monoclonal, Humanized
0
Interleukin 1 Receptor Antagonist Protein
0
Interleukin-1beta
0
Receptors, Interleukin-1
0
canakinumab
37CQ2C7X93
Types de publication
Journal Article
Review
Langues
eng
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