Emerging role of F-box proteins in the regulation of epithelial-mesenchymal transition and stem cells in human cancers.
Cancer
Drug resistance
EMT
F-box protein
Metastasis
Stem cells
Journal
Stem cell research & therapy
ISSN: 1757-6512
Titre abrégé: Stem Cell Res Ther
Pays: England
ID NLM: 101527581
Informations de publication
Date de publication:
18 04 2019
18 04 2019
Historique:
entrez:
20
4
2019
pubmed:
20
4
2019
medline:
26
6
2020
Statut:
epublish
Résumé
Emerging evidence shows that epithelial-mesenchymal transition (EMT) plays a crucial role in tumor invasion, metastasis, cancer stem cells, and drug resistance. Data obtained thus far have revealed that F-box proteins are critically involved in the regulation of the EMT process and stem cell differentiation in human cancers. In this review, we will briefly describe the role of EMT and stem cells in cell metastasis and drug resistance. We will also highlight how numerous F-box proteins govern the EMT process and stem cell survival by controlling their downstream targets. Additionally, we will discuss whether F-box proteins involved in drug resistance are associated with EMT and cancer stem cells. Targeting these F-box proteins might be a potential therapeutic strategy to reverse EMT and inhibit cancer stem cells and thus overcome drug resistance in human cancers.
Identifiants
pubmed: 30999935
doi: 10.1186/s13287-019-1222-0
pii: 10.1186/s13287-019-1222-0
pmc: PMC6472071
doi:
Substances chimiques
F-Box Proteins
0
Neoplasm Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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