Mouse ANKRD31 Regulates Spatiotemporal Patterning of Meiotic Recombination Initiation and Ensures Recombination between X and Y Sex Chromosomes.

Animals Carrier Proteins / chemistry Chromosome Segregation / genetics DNA Breaks, Double-Stranded Homologous Recombination / genetics Male Meiosis / genetics Mice Pseudoautosomal Regions / genetics Spermatocytes / growth & development X Chromosome / genetics Y Chromosome / genetics
IHO1 MEI4 PRDM9 REC114 genome integrity in the germline hotspots mammalian reproduction meiosis recombination between psuedoautosomal regions of sex chromosomes recombinosome assembly on chromosome axis

Journal

Molecular cell
ISSN: 1097-4164
Titre abrégé: Mol Cell
Pays: United States
ID NLM: 9802571

Informations de publication

Date de publication:
06 06 2019
Historique:
received: 27 09 2018
revised: 01 02 2019
accepted: 20 03 2019
pubmed: 20 4 2019
medline: 23 10 2019
entrez: 20 4 2019
Statut: ppublish

Résumé

Orderly segregation of chromosomes during meiosis requires that crossovers form between homologous chromosomes by recombination. Programmed DNA double-strand breaks (DSBs) initiate meiotic recombination. We identify ANKRD31 as a key component of complexes of DSB-promoting proteins that assemble on meiotic chromosome axes. Genome-wide, ANKRD31 deficiency causes delayed recombination initiation. In addition, loss of ANKRD31 alters DSB distribution because of reduced selectivity for sites that normally attract DSBs. Strikingly, ANKRD31 deficiency also abolishes uniquely high rates of recombination that normally characterize pseudoautosomal regions (PARs) of X and Y chromosomes. Consequently, sex chromosomes do not form crossovers, leading to chromosome segregation failure in ANKRD31-deficient spermatocytes. These defects co-occur with a genome-wide delay in assembling DSB-promoting proteins on autosome axes and loss of a specialized PAR-axis domain that is highly enriched for DSB-promoting proteins in wild type. Thus, we propose a model for spatiotemporal patterning of recombination by ANKRD31-dependent control of axis-associated DSB-promoting proteins.

Identifiants

DOI: 10.1016/j.molcel.2019.03.022 PMID: 31000436
pubmed: 31000436
pii: S1097-2765(19)30226-6
doi: 10.1016/j.molcel.2019.03.022
pii:
doi:

Substances chimiques

Carrier Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1069-1085.e11

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Frantzeskos Papanikos (F)

Institute of Physiological Chemistry, Faculty of Medicine, Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany.

Julie A J Clément (JAJ)

Institute of Human Genetics, UMR 9002, CNRS, Université de Montpellier, 34396 Montpellier Cedex 5, France.

Erika Testa (E)

Department of Biomedicine and Prevention, Faculty of Medicine, University of Rome Tor Vergata, Via Montpellier n.1, 00133 Rome, Italy.

Ramya Ravindranathan (R)

Institute of Physiological Chemistry, Faculty of Medicine, Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany.

Corinne Grey (C)

Institute of Human Genetics, UMR 9002, CNRS, Université de Montpellier, 34396 Montpellier Cedex 5, France.

Ihsan Dereli (I)

Institute of Physiological Chemistry, Faculty of Medicine, Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany.

Anastasiia Bondarieva (A)

Institute of Physiological Chemistry, Faculty of Medicine, Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany.

Sarai Valerio-Cabrera (S)

Institute of Physiological Chemistry, Faculty of Medicine, Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany.

Marcello Stanzione (M)

Institute of Physiological Chemistry, Faculty of Medicine, Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany.

Alexander Schleiffer (A)

Research Institute of Molecular Pathology (IMP), Campus Vienna BioCenter 1, Vienna BioCenter (VBC), 1030 Vienna, Austria; Institute of Molecular Biotechnology (IMBA), Dr. Bohr-Gasse 3, Vienna BioCenter (VBC), 1030 Vienna, Austria.

Petr Jansa (P)

Institute of Molecular Genetics, Division BIOCEV, Prumyslova 595, 25250 Vestec, Czech Republic.

Diana Lustyk (D)

Institute of Molecular Genetics, Division BIOCEV, Prumyslova 595, 25250 Vestec, Czech Republic.

Ji-Feng Fei (JF)

Institute for Brain Research and Rehabilitation, South China Normal University, 510631 Guangzhou, China.

Ian R Adams (IR)

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.

Jiri Forejt (J)

Institute of Molecular Genetics, Division BIOCEV, Prumyslova 595, 25250 Vestec, Czech Republic.

Marco Barchi (M)

Department of Biomedicine and Prevention, Faculty of Medicine, University of Rome Tor Vergata, Via Montpellier n.1, 00133 Rome, Italy.

Bernard de Massy (B)

Institute of Human Genetics, UMR 9002, CNRS, Université de Montpellier, 34396 Montpellier Cedex 5, France. Electronic address: bernard.de-massy@igh.cnrs.fr.

Attila Toth (A)

Institute of Physiological Chemistry, Faculty of Medicine, Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany. Electronic address: attila.toth@mailbox.tu-dresden.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mouse ANKRD31 Regulates Spatiotemporal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Mouse ANKRD31 Regulates Spatiotemporal...
questionsmedicales.fr › Phénomènes génétiques › Division du noyau cellulaire › Ségrégation des chromosomes › Mouse ANKRD31 Regulates Spatiotemporal...
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › Cassures de l'ADN › Cassures double-brin de l'ADN › Mouse ANKRD31 Regulates Spatiotemporal...
questionsmedicales.fr › Phénomènes génétiques › Recombinaison génétique › Recombinaison homologue › Mouse ANKRD31 Regulates Spatiotemporal...
questionsmedicales.fr › Phénomènes génétiques › Division du noyau cellulaire › Méiose › Mouse ANKRD31 Regulates Spatiotemporal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Mouse ANKRD31 Regulates Spatiotemporal...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Régions pseudo-autosomiques › Mouse ANKRD31 Regulates Spatiotemporal...
questionsmedicales.fr › Cellules › Cellules germinales › Spermatozoïdes › Spermatocytes › Mouse ANKRD31 Regulates Spatiotemporal...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Chromosomes › Chromosomes sexuels › Chromosome X › Mouse ANKRD31 Regulates Spatiotemporal...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Chromosomes › Chromosomes sexuels › Chromosome Y › Mouse ANKRD31 Regulates Spatiotemporal...