Neutrophil properties in healthy and Leishmania infantum-naturally infected dogs.
Animals
Dog Diseases
/ blood
Dogs
Extracellular Traps
/ parasitology
Female
Interferon-gamma
/ metabolism
Interleukin-4
/ metabolism
Interleukin-8
/ metabolism
Leishmania infantum
/ pathogenicity
Leishmaniasis, Visceral
/ blood
Male
Neutrophils
/ metabolism
Phagocytosis
Tumor Necrosis Factor-alpha
/ metabolism
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
18 04 2019
18 04 2019
Historique:
received:
17
09
2018
accepted:
28
02
2019
entrez:
20
4
2019
pubmed:
20
4
2019
medline:
11
11
2020
Statut:
epublish
Résumé
Visceral leishmaniasis is a chronic disease that affects humans and dogs as well. Dogs, the domestic reservoir of Leishmania, play a central role in the transmission of visceral leishmaniasis, the most severe form of this disease. Neutrophils are the most abundant leukocytes in blood and interact with the parasite after infection. Here, we evaluate the effector properties of neutrophils from healthy and naturally Leishmania infantum-infected dogs. Our results showed that the parasite induced neutrophil extracellular trap (NET) release from neutrophils in both groups. Additionally, phagocytosis and NETs contributed differently to parasite killing by neutrophils from healthy and infected animals, and IFN-γ, IL-8, IL-4 and TNF-α production by neutrophils from both groups were differentially modulated by the parasite. Our results contribute to a better understanding of the complex role played by neutrophils in canine visceral leishmaniasis, which may favor the development of more effective therapies.
Identifiants
pubmed: 31000764
doi: 10.1038/s41598-019-42687-9
pii: 10.1038/s41598-019-42687-9
pmc: PMC6472404
doi:
Substances chimiques
Interleukin-8
0
Tumor Necrosis Factor-alpha
0
Interleukin-4
207137-56-2
Interferon-gamma
82115-62-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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