Evaluating laboratory criteria for combined immunodeficiency in adult patients diagnosed with common variable immunodeficiency.
Adult
Biomarkers
CD4-Positive T-Lymphocytes
/ immunology
Cells, Cultured
Cohort Studies
Common Variable Immunodeficiency
/ diagnosis
Diagnosis, Differential
Female
Humans
Lymphocyte Count
Male
Middle Aged
Patient Selection
Retrospective Studies
Sensitivity and Specificity
Severe Combined Immunodeficiency
/ diagnosis
T-Lymphocyte Subsets
/ immunology
CID
CVID
Combined immunodeficiency
Complications
Definition
Opportunistic infection
naïve CD4 T cells
Journal
Clinical immunology (Orlando, Fla.)
ISSN: 1521-7035
Titre abrégé: Clin Immunol
Pays: United States
ID NLM: 100883537
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
04
01
2019
revised:
25
03
2019
accepted:
02
04
2019
pubmed:
21
4
2019
medline:
3
4
2020
entrez:
21
4
2019
Statut:
ppublish
Résumé
Some patients diagnosed with common variable immunodeficiency (CVID) actually suffer from combined immunodeficiency (CID) and therefore may require a different, CID-adapted treatment. Several CD4 T-cell-based criteria have been proposed in the past to identify patients with CID within the cohort of adult CVID patients. In this monocentric study, we used retrospective immunological and clinical data of 238 CVID patients to compare four different proposals of how to define CID among CVID patients. We demonstrate that none of the current definitions sufficiently separates CID from CVID patients and that the relative reduction of naïve CD4 T cells <10% has the highest sensitivity of all tested markers for patients with clinical complications often associated with CID. Thus, a very low percentage of naïve CD4 T cells in any adult CVID patient should raise suspicion, but is not sufficient to define CID among CVID patients.
Identifiants
pubmed: 31004792
pii: S1521-6616(19)30004-X
doi: 10.1016/j.clim.2019.04.001
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
59-62Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.