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"@type": "Question",
"name": "Quel rôle joue l'historique médical dans le diagnostic ?",
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"@type": "Question",
"name": "Les tests génétiques sont-ils nécessaires pour le DICV ?",
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"@type": "Question",
"name": "Quels sont les symptômes courants du DICV ?",
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"@type": "Question",
"name": "Le DICV provoque-t-il des symptômes auto-immuns ?",
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"text": "Oui, il peut entraîner des symptômes auto-immuns comme l'arthrite ou des éruptions cutanées."
}
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"@type": "Question",
"name": "Les symptômes varient-ils d'une personne à l'autre ?",
"position": 8,
"acceptedAnswer": {
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"text": "Oui, l'intensité et la nature des symptômes peuvent varier considérablement entre les individus."
}
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{
"@type": "Question",
"name": "Les symptômes apparaissent-ils à un âge spécifique ?",
"position": 9,
"acceptedAnswer": {
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"text": "Les symptômes peuvent apparaître à tout âge, souvent entre 20 et 40 ans."
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{
"@type": "Question",
"name": "Y a-t-il des signes d'alerte pour le DICV ?",
"position": 10,
"acceptedAnswer": {
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"text": "Des infections récurrentes et des maladies auto-immunes sont des signes d'alerte importants."
}
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{
"@type": "Question",
"name": "Comment prévenir les infections chez les patients DICV ?",
"position": 11,
"acceptedAnswer": {
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"text": "La prévention inclut la vaccination, l'hygiène rigoureuse et l'évitement des foules."
}
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{
"@type": "Question",
"name": "Les vaccinations sont-elles recommandées ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les vaccinations sont recommandées, mais certaines doivent être évitées selon le cas."
}
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{
"@type": "Question",
"name": "Le mode de vie influence-t-il la prévention ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sain, incluant une alimentation équilibrée, aide à renforcer l'immunité."
}
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{
"@type": "Question",
"name": "Les patients doivent-ils éviter certains environnements ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, éviter les environnements à risque élevé d'infection est conseillé."
}
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{
"@type": "Question",
"name": "Des conseils spécifiques existent-ils pour les patients ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des conseils incluent l'évitement des personnes malades et le port de masques en public."
}
},
{
"@type": "Question",
"name": "Quel est le traitement principal du DICV ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement principal est l'immunoglobuline intraveineuse ou sous-cutanée pour prévenir les infections."
}
},
{
"@type": "Question",
"name": "Des médicaments immunosuppresseurs sont-ils utilisés ?",
"position": 17,
"acceptedAnswer": {
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"text": "Oui, des médicaments immunosuppresseurs peuvent être prescrits pour traiter les maladies auto-immunes associées."
}
},
{
"@type": "Question",
"name": "Le traitement est-il à vie ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le traitement est généralement à vie pour maintenir une immunité adéquate."
}
},
{
"@type": "Question",
"name": "Y a-t-il des effets secondaires aux traitements ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les effets secondaires peuvent inclure des réactions allergiques et des infections."
}
},
{
"@type": "Question",
"name": "Comment surveille-t-on l'efficacité du traitement ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'efficacité est surveillée par des tests sanguins réguliers et l'évaluation des infections."
}
},
{
"@type": "Question",
"name": "Quelles sont les complications possibles du DICV ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des infections chroniques, des maladies auto-immunes et des cancers."
}
},
{
"@type": "Question",
"name": "Le DICV augmente-t-il le risque de cancer ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les patients DICV ont un risque accru de certains types de cancer, notamment lymphomateux."
}
},
{
"@type": "Question",
"name": "Comment les infections chroniques affectent-elles la vie ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les infections chroniques peuvent entraîner une fatigue, des hospitalisations fréquentes et une qualité de vie réduite."
}
},
{
"@type": "Question",
"name": "Les maladies auto-immunes sont-elles fréquentes ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les maladies auto-immunes sont fréquentes chez les patients DICV, affectant divers systèmes."
}
},
{
"@type": "Question",
"name": "Comment gérer les complications du DICV ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "La gestion inclut un suivi médical régulier, des traitements appropriés et un soutien psychologique."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque du DICV ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des antécédents familiaux, des infections fréquentes et des maladies auto-immunes."
}
},
{
"@type": "Question",
"name": "Le sexe influence-t-il le risque de DICV ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le DICV est plus fréquent chez les hommes que chez les femmes, bien que les deux sexes soient touchés."
}
},
{
"@type": "Question",
"name": "L'âge joue-t-il un rôle dans le DICV ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, bien que le DICV puisse survenir à tout âge, il est souvent diagnostiqué chez les jeunes adultes."
}
},
{
"@type": "Question",
"name": "Les infections précoces augmentent-elles le risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des infections précoces dans l'enfance peuvent être un facteur de risque pour le DICV."
}
},
{
"@type": "Question",
"name": "Y a-t-il des facteurs environnementaux associés ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains facteurs environnementaux, comme l'exposition à des agents infectieux, peuvent jouer un rôle."
}
}
]
}
]
}
Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran.
Iranian Primary Immunodeficiencies Network (IPIN), Tehran University of Medical Sciences, Tehran, Iran.
Publications dans "Déficit immunitaire commun variable" :
Iranian Primary Immunodeficiencies Network (IPIN), Tehran University of Medical Sciences, Tehran, Iran.
Research Center for Primary Immunodeficiency, Iran University of Medical Sciences, Tehran, Iran.
Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute at the Karolinska University Hospital Huddinge, Stockholm, Sweden.
Publications dans "Déficit immunitaire commun variable" :
Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran, aghamohammadi@sina.tums.ac.ir.
Iranian Primary Immunodeficiencies Network (IPIN), Tehran University of Medical Sciences, Tehran, Iran, aghamohammadi@sina.tums.ac.ir.
Publications dans "Déficit immunitaire commun variable" :
1Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), World Allergy Organization (WAO) Center of Excellence, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.
Publications dans "Déficit immunitaire commun variable" :
Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran.
Publications dans "Déficit immunitaire commun variable" :
Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Institute for Immunodeficiency, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; DZIF - German Center for Infection Research, Satellite Center Freiburg, Germany; CIBSS - Centre for Integrative Biological Signalling Studies, Albert-Ludwigs University, Freiburg, Germany; RESIST - Cluster of Excellence 2155 to Hanover Medical School, Satellite Center Freiburg, Germany.
Publications dans "Déficit immunitaire commun variable" :
1Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), World Allergy Organization (WAO) Center of Excellence, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.
Publications dans "Déficit immunitaire commun variable" :
1Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), World Allergy Organization (WAO) Center of Excellence, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.
Publications dans "Déficit immunitaire commun variable" :
1Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), World Allergy Organization (WAO) Center of Excellence, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.
Publications dans "Déficit immunitaire commun variable" :
Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Especialidades, Servicio de Alergia e Inmunología Clínica. Clínica de Errores Innatos de la Inmunidad. Ciudad de México, México.
Publications dans "Déficit immunitaire commun variable" :
Common variable immunodeficiency (CVID) is the most common primary immune deficiency characterized by impaired production of specific immunoglobulin. The clinical manifestations are heterogeneous incl...
Common variable immunodeficiency (CVID) is the most common symptomatic antibody deficiency, characterized by heterogeneous genetic, immunological, and clinical phenotypes. It is no longer conceived as...
Up to 25% of patients with common variable immunodeficiency (CVID) debut with autoimmunity, which is related to the Freiburg classification, which is based on flow cytometry....
to determine the frequency and type of autoimmune diseases and their association with the Freiburg classification in adults with CVID....
A cross-sectional, analytical and observational study was carried out with 33 patients belonging to the Primary Immunodeficiency Clinic of a third level hospital, with a diagnosis of CVID. They were d...
Of the 33 patients studied, 66.6% presented autoimmune diseases, 19 of them (86.3%) had cytopenia; 42.1% belonged to Freiburg group Ia, 36.8% to Ib and 21% to phenotype II. In 36.6% of the patients, a...
Classification by CVID phenotypes allows the identification of the patient's profile according to the percentage of memory B cells with isotype change, which is useful to intentionally search for non-...
Delayed diagnosis of common variable immunodeficiency (CVID) remains a serious problem. We investigated whether some diseases diagnosed during out-patient visits or admission to hospitals could act as...
In this nested case-control study, we identified 128 cases diagnosed with CVID in Denmark (1999-2013) and 640 age-, gender-, and region-matched controls. We obtained data on diseases diagnosed at hosp...
During the five years preceding a CVID diagnosis, cases had four times as many hospital contacts as the controls (p < 0.001). A diagnosis in 18 major disease categories showed a significant OR for sub...
Targeted screening for antibody deficiency in patients diagnosed with specific diseases associated with CVID may lead to earlier CVID diagnosis and treatment and thereby potentially reduced morbidity ...
Common variable immunodeficiency enteropathy (CVID-E) is a noninfectious complication of CVID caused by chronic inflammation of the gastrointestinal (GI) tract. Based on literature, a paucity or lack ...
Reduced plasma cell counts are commonly found over the entire GI tract, except for in the oesophagus. Immunoglobulin A+ (IgA+) plasma cells appear to be the most commonly reduced plasma cell class in ...
We propose two optimized methodologies of quantification using a cut-of value of <10 plasma cells per HPF at 40× magnification, or a proportion of ≥1-5% of total mononuclear cells, recorded over ≥3 se...
Estimate the prevalence of dermatological manifestations in Mexican patients with common variable immunodeficiency....
Cross-sectional and retrospective study, based on the analysis of records of patients with a diagnosis of common variable immunodeficiency, treated at the Siglo XXI National Medical Center (Mexican So...
36 patients were included, of which 55.5% were women; with median age 34 years (18-94). The prevalence of dermatological manifestations was 70% (n = 25). 30.5% had a history of infectious dermatosis a...
Common variable immunodeficiency is an inborn error of immunity, with different clinical manifestations in various organs and systems (the skin is one of these). Dermatological manifestations are not ...
Common Variable Immunodeficiency (CVID) is a primary immunodeficiency syndrome resulting in recurrent infections, autoimmunity, and granulomatous manifestations....
This retrospective study was conducted on an Iranian national registry of immunodeficient patients from 2010 to 2021. The frequency of first presentations of CVID and its association with sex, age of ...
A total of 383 patients entered the study, 164 of whom were female, and the rest were male. The mean age of the patients was 25.3 ± 14.5 years. The most frequent first presentations of CVID were pneum...
pneumonia is the most common first presentation of CVID. Family history of CVID, the age of symptom onset, and sex made no differences in the first presentations of CVID....
A male patient in his 20s with a medical history of common variable immunodeficiency disorder, non-compliant with therapy, presented to the emergency department with respiratory distress and severe hy...
Common variable immunodeficiency (CVID) is the most common symptomatic inborn error of immunity. The disorder is characterized by variable clinical and immunological manifestations, and, in a small mi...
Activated phosphoinositide 3-kinase delta syndrome (APDS) is a rare disorder characterized by hyperactivated class I phosphatidylinositol-3 kinase (PI3K) pathway. Affected patients present with respir...
Understanding the biological basis of CVID is important not only for enriching our knowledge of the human immune system, but also for setting the basis for potential targeted treatments in this disord...
To compare the consumption of antibiotics (AB), systemic steroids, and inhaled bronchodilators/glucocorticoids in the 3 years preceding the diagnosis of common variable immunodeficiency (CVID) among C...
We conducted a nested case-control study, identifying all individuals (n=130 cases) diagnosed with CVID in Denmark (1994-2014) and 45 age- and sex-matched population controls per case (n=5850 controls...
In the 3 years preceding a CVID diagnosis, we observed more frequent and higher consumption of all three drug classes. The association between consumption and risk of subsequent CVID diagnosis was sta...
CVID patients have significantly higher use of AB, systemic steroids, and inhaled bronchodilators/glucocorticoids in the 3 years preceding CVID diagnosis than controls. Prescribing these drugs in prim...