Is there a role for microbiome-based approach in common variable immunodeficiency?
Common variable immunodeficiency
Fecal microbiota transplantation
Gut microbiome
Microbiome-based therapies
Personalized medicine
Journal
Clinical and experimental medicine
ISSN: 1591-9528
Titre abrégé: Clin Exp Med
Pays: Italy
ID NLM: 100973405
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
29
12
2022
accepted:
18
01
2023
medline:
2
10
2023
pubmed:
4
2
2023
entrez:
3
2
2023
Statut:
ppublish
Résumé
Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by low levels of serum immunoglobulins and increased susceptibility to infections, autoimmune disorders and cancer. CVID embraces a plethora of heterogeneous manifestations linked to complex immune dysregulation. While CVID is thought to be due to genetic defects, the exact cause of this immune disorder is unknown in the large majority of cases. Compelling evidences support a linkage between the gut microbiome and the CVID pathogenesis, therefore a potential for microbiome-based treatments to be a therapeutic pathway for this disorder. Here we discuss the potential of treating CVID patients by developing a gut microbiome-based personalized approach, including diet, prebiotics, probiotics, postbiotics and fecal microbiota transplantation. We also highlight the need for a better understanding of microbiota-host interactions in CVID patients to prime the development of improved preventive strategies and specific therapeutic targets.
Identifiants
pubmed: 36737487
doi: 10.1007/s10238-023-01006-3
pii: 10.1007/s10238-023-01006-3
pmc: PMC9897624
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1981-1998Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2023. The Author(s).
Références
Front Immunol. 2019 Oct 23;10:2484
pubmed: 31708923
JAMA. 2017 Nov 28;318(20):1985-1993
pubmed: 29183074
JAMA. 2014 Nov 5;312(17):1772-8
pubmed: 25322359
J Allergy Clin Immunol. 2014 Jul;134(1):116-26
pubmed: 24582312
Clin Immunol. 2004 Jul;112(1):24-9
pubmed: 15207778
J Clin Gastroenterol. 2014 Nov-Dec;48 Suppl 1:S80-4
pubmed: 25291136
J Allergy Clin Immunol. 2023 Mar;151(3):767-777
pubmed: 36220400
Ann Nutr Metab. 2012;61(2):160-74
pubmed: 23037511
Nat Rev Gastroenterol Hepatol. 2019 Jan;16(1):35-56
pubmed: 30262901
Nat Rev Immunol. 2016 May;16(5):295-309
pubmed: 27087661
Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1306-15
pubmed: 26884164
Nat Med. 2019 Jul;25(7):1096-1103
pubmed: 31263284
Nat Rev Immunol. 2013 Jul;13(7):519-33
pubmed: 23765059
Infect Immun. 1988 Oct;56(10):2610-4
pubmed: 3417352
Front Immunol. 2017 Aug 28;8:1036
pubmed: 28894447
Gut. 2018 Aug;67(8):1445-1453
pubmed: 29269438
Nat Rev Immunol. 2016 May 27;16(6):341-52
pubmed: 27231050
Cell Res. 2020 Jun;30(6):492-506
pubmed: 32433595
Nutrients. 2014 Dec 24;7(1):17-44
pubmed: 25545101
J Cell Physiol. 2019 Jun;234(6):8008-8018
pubmed: 30317594
Front Immunol. 2020 Aug 27;11:1921
pubmed: 32983117
PLoS One. 2013;8(4):e60042
pubmed: 23565181
Gut. 2020 Sep;69(9):1555-1563
pubmed: 32620549
Am J Gastroenterol. 2012 Oct;107(10):1452-9
pubmed: 23034604
Ann Intern Med. 2015 Sep 15;163(6):487-8
pubmed: 26370022
J Crohns Colitis. 2016 Apr;10(4):387-94
pubmed: 26519463
Clin Immunol. 2018 Dec;197:139-153
pubmed: 30240602
Front Immunol. 2020 Feb 28;11:338
pubmed: 32184784
Int J Food Sci Nutr. 2006 Nov-Dec;57(7-8):470-80
pubmed: 17162326
Vaccines (Basel). 2017 Dec 11;5(4):
pubmed: 29232932
Sci Rep. 2019 Jan 17;9(1):167
pubmed: 30655568
Digestion. 2017;96(1):29-38
pubmed: 28628918
Am J Gastroenterol. 2013 Apr;108(4):500-8
pubmed: 23511459
Rev Gastroenterol Mex (Engl Ed). 2019 Jan - Mar;84(1):110-112
pubmed: 29449093
Ann Gastroenterol. 2019 Jan-Feb;32(1):30-38
pubmed: 30598589
Adv Microb Physiol. 1998;39:205-34
pubmed: 9328648
J Immunol Res. 2014;2014:462740
pubmed: 24995345
FASEB J. 2000 Dec;14(15):2380-2
pubmed: 11024006
Am J Physiol Gastrointest Liver Physiol. 2004 Apr;286(4):G613-26
pubmed: 15010363
Front Immunol. 2021 May 14;12:671239
pubmed: 34054845
J Clin Gastroenterol. 2018 Nov/Dec;52 Suppl 1, Proceedings from the 9th Probiotics, Prebiotics and:S74-S77
pubmed: 29912755
Sci Adv. 2021 May 12;7(20):
pubmed: 33980483
Eur J Nutr. 2021 Mar;60(2):929-938
pubmed: 32548645
Acta Pharmacol Sin. 2020 May;41(5):678-685
pubmed: 31937933
Mucosal Immunol. 2016 Nov;9(6):1455-1465
pubmed: 26982597
J Microbiol Biotechnol. 2008 Jul;18(7):1278-85
pubmed: 18667857
Nature. 2011 Sep 21;478(7368):250-4
pubmed: 21937990
Cell. 2018 Sep 6;174(6):1388-1405.e21
pubmed: 30193112
Exp Mol Med. 2018 Feb 23;50(2):e450
pubmed: 29472701
Cell. 2021 Aug 5;184(16):4137-4153.e14
pubmed: 34256014
Cell Mol Life Sci. 2019 Feb;76(3):473-493
pubmed: 30317530
Eur Ann Allergy Clin Immunol. 2021 Jan;53(1):18-22
pubmed: 32186350
Scand J Immunol. 2018 May;87(5):e12663
pubmed: 29574865
Aliment Pharmacol Ther. 2014 Jul;40(1):119
pubmed: 24903435
Nat Rev Gastroenterol Hepatol. 2022 Oct;19(10):625-637
pubmed: 35641786
Crit Rev Biochem Mol Biol. 2019 Apr;54(2):184-192
pubmed: 31084433
BMC Gastroenterol. 2014 Nov 18;14:189
pubmed: 25407511
Clin Infect Dis. 2019 Apr 8;68(8):1351-1358
pubmed: 30957161
Neurochem Res. 2021 Sep;46(9):2348-2358
pubmed: 34106394
Am J Gastroenterol. 2010 Oct;105(10):2262-75
pubmed: 20551941
Heliyon. 2022 Jun 22;8(6):e09725
pubmed: 35785237
Clin Rev Allergy Immunol. 2018 Apr;54(2):261-268
pubmed: 29030829
Nat Rev Microbiol. 2011 Apr;9(4):233-43
pubmed: 21358670
Front Immunol. 2018 Nov 05;9:2546
pubmed: 30455695
Cell. 2016 Nov 3;167(4):1125-1136.e8
pubmed: 27814509
Science. 2013 Aug 2;341(6145):569-73
pubmed: 23828891
Cancers (Basel). 2019 Jan 03;11(1):
pubmed: 30609850
Am J Physiol. 1992 May;262(5 Pt 1):G813-7
pubmed: 1590391
Respir Res. 2010 Mar 20;11:33
pubmed: 20302656
Curr Gastroenterol Rep. 2004 Oct;6(5):377-83
pubmed: 15341713
AIDS Res Hum Retroviruses. 2022 Sep;38(9):700-708
pubmed: 35451337
Microbiome. 2013 Jan 09;1(1):3
pubmed: 24467987
Hepatology. 2017 Dec;66(6):1727-1738
pubmed: 28586116
J Clin Med. 2020 Jun 05;9(6):
pubmed: 32517023
Microbiology (Reading). 2017 May;163(5):646-648
pubmed: 28530168
Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16731-6
pubmed: 18936492
Nat Med. 2019 Mar;25(3):377-388
pubmed: 30842679
Immunol Allergy Clin North Am. 2019 Feb;39(1):81-94
pubmed: 30466774
Clin Immunol. 1999 Jul;92(1):34-48
pubmed: 10413651
Recent Pat Inflamm Allergy Drug Discov. 2017;10(2):105-118
pubmed: 28029082
Clin Mol Allergy. 2019 May 6;17:9
pubmed: 31080365
Front Microbiol. 2019 Jun 10;10:1136
pubmed: 31244784
Gut. 2014 May;63(5):727-35
pubmed: 23804561
J Allergy Clin Immunol. 2018 Mar;141(3):1028-1035
pubmed: 28606585
Hepatology. 2012 Feb;55(2):655-6
pubmed: 22030839
Nat Rev Immunol. 2019 May;19(5):305-323
pubmed: 30858494
Appl Environ Microbiol. 2015 Jun;81(11):3655-62
pubmed: 25795669
Nature. 2013 Dec 19;504(7480):451-5
pubmed: 24226773
Gut. 2019 Mar;68(3):453-464
pubmed: 30064988
Lancet Gastroenterol Hepatol. 2018 Jan;3(1):17-24
pubmed: 29100842
Cell. 2015 Dec 17;163(7):1585-95
pubmed: 26687352
J Allergy Clin Immunol Pract. 2018 Jan - Feb;6(1):159-168.e3
pubmed: 28734862
Anaerobe. 2018 Apr;50:32-37
pubmed: 29408016
United European Gastroenterol J. 2021 Mar;9(2):229-247
pubmed: 33151137
Nutrients. 2020 May 20;12(5):
pubmed: 32443748
Ann Intensive Care. 2016 Dec;6(1):96
pubmed: 27714706
Clin Infect Dis. 2008 May 15;46(10):1547-54
pubmed: 18419489
Blood. 2012 Feb 16;119(7):1650-7
pubmed: 22180439
Nutrients. 2013 Apr 22;5(4):1417-35
pubmed: 23609775
Gastroenterology. 2017 Mar;152(4):799-811.e7
pubmed: 27866880
Food Microbiol. 2016 Feb;53(Pt A):60-9
pubmed: 26611170
J Allergy Clin Immunol Pract. 2013 Nov-Dec;1(6):545-56; quiz 557
pubmed: 24565700
Gut. 2003 Jun;52(6):827-33
pubmed: 12740338
Dig Liver Dis. 2019 Nov;51(11):1599-1603
pubmed: 31155490
Immunol Rev. 2019 Jan;287(1):145-161
pubmed: 30565247
J Appl Microbiol. 2008 Feb;104(2):595-604
pubmed: 17927751
Curr Pharm Biotechnol. 2018;19(9):734-741
pubmed: 30336770
Curr Opin Biotechnol. 2020 Feb;61:226-234
pubmed: 32087535
Crit Rev Food Sci Nutr. 2021;61(2):337-355
pubmed: 32156153
Proc Nutr Soc. 2003 Feb;62(1):67-72
pubmed: 12740060
J Biol Chem. 2002 Dec 27;277(52):50959-65
pubmed: 12393915
Nat Commun. 2020 Apr 8;11(1):1738
pubmed: 32269218
ISME J. 2014 Aug;8(8):1621-33
pubmed: 24577353
Sci Rep. 2020 Dec 10;10(1):21641
pubmed: 33303854
Transplantation. 2017 Jan;101(1):74-82
pubmed: 27681266
Int J Mol Sci. 2014 Jul 01;15(7):11678-99
pubmed: 24987952
Front Nutr. 2021 Oct 28;8:718093
pubmed: 34778332
Front Immunol. 2020 Jul 31;11:1654
pubmed: 32849570
mBio. 2017 Sep 19;8(5):
pubmed: 28928206
Cell. 2014 Mar 27;157(1):121-41
pubmed: 24679531
J Vis Exp. 2014 Dec 08;(94):
pubmed: 25549239
Clin Immunol. 2017 Jul;180:1-4
pubmed: 28347823
Clin Infect Dis. 2012 Oct;55(7):905-14
pubmed: 22718773
Food Chem Toxicol. 2019 Jul;129:22-29
pubmed: 31009735
Gut Microbes. 2017 Mar 4;8(2):113-129
pubmed: 27960648
Gut. 2015 Jun;64(6):872-83
pubmed: 25080446
Exp Mol Med. 2017 May 26;49(5):e339
pubmed: 28546562
Front Microbiol. 2020 Sep 11;11:562048
pubmed: 33042069
Nutr Res. 2008 May;28(5):321-8
pubmed: 19083427
Exp Cell Res. 2001 Feb 1;263(1):163-72
pubmed: 11161715
J Pediatr (Rio J). 2015 Sep-Oct;91(5):413-27
pubmed: 26054771
Helicobacter. 2017 Sep;22 Suppl 1:
pubmed: 28891133
J Clin Immunol. 2023 Feb;43(2):371-390
pubmed: 36282455
Diabetologia. 2012 Aug;55(8):2285-94
pubmed: 22572803
Gut. 2004 Sep;53(9):1388-9
pubmed: 15306608
J Med Genet. 2016 Sep;53(9):575-90
pubmed: 27250108
Ann Allergy Asthma Immunol. 2015 May;114(5):364-9
pubmed: 25752734
Trends Food Sci Technol. 2020 Aug;102:178-192
pubmed: 32834500
Clin Gastroenterol Hepatol. 2010 May;8(5):471-3
pubmed: 20117243
Front Microbiol. 2017 Sep 12;8:1725
pubmed: 28955311
Aliment Pharmacol Ther. 2018 Jan;47(1):67-77
pubmed: 29052237
Clin Nutr. 2003 Oct;22(5):463-71
pubmed: 14512034
Cureus. 2022 May 5;14(5):e24754
pubmed: 35693372
Am J Gastroenterol. 2014 Jul;109(7):1065-71
pubmed: 24890442
Front Immunol. 2019 Aug 13;10:1914
pubmed: 31456808
J Exp Med. 2020 Feb 13;217(3):e20192195
pubmed: 32997932
Front Immunol. 2022 Jun 20;13:869466
pubmed: 35795667
Nature. 2009 Oct 29;461(7268):1282-6
pubmed: 19865172
Ann Allergy Asthma Immunol. 2019 Nov;123(5):454-460
pubmed: 31349011
Curr Pharm Des. 2014;20(28):4565-9
pubmed: 24180411
Chest. 2002 Dec;122(6):2042-9
pubmed: 12475845
Ann Nutr Metab. 2019;74(2):115-124
pubmed: 30673668
Front Microbiol. 2016 Jan 12;6:1543
pubmed: 26793178
N Engl J Med. 2013 Jan 31;368(5):407-15
pubmed: 23323867
Nat Microbiol. 2017 Apr 25;2:17057
pubmed: 28440276
Diabetes. 2015 Aug;64(8):2847-58
pubmed: 25845659
Aliment Pharmacol Ther. 2021 Jan;53(1):33-42
pubmed: 33159374
J Allergy Clin Immunol. 2023 Mar;151(3):697-699
pubmed: 36621651
Microb Ecol Health Dis. 2015 Feb 02;26:26050
pubmed: 25651996
Gut. 2005 Feb;54(2):242-9
pubmed: 15647189
Nat Rev Gastroenterol Hepatol. 2022 Aug;19(8):551
pubmed: 35538163
Science. 2019 Jun 21;364(6446):1179-1184
pubmed: 31221858
Front Cell Infect Microbiol. 2022 Mar 17;12:826114
pubmed: 35372103
Clin Exp Immunol. 2002 Dec;130(3):495-500
pubmed: 12452841
Nat Med. 2021 Feb;27(2):321-332
pubmed: 33432175
Front Immunol. 2019 Sep 10;10:2113
pubmed: 31552046
Front Immunol. 2020 Feb 07;11:149
pubmed: 32117289
J Biol Chem. 2017 May 26;292(21):8560-8568
pubmed: 28389555
Rev Esp Enferm Dig. 2013 Sep;105(8):445-53
pubmed: 24274441
Sci Rep. 2018 Mar 22;8(1):5065
pubmed: 29567956
Front Immunol. 2022 Oct 20;13:933463
pubmed: 36341360
Ann Allergy Asthma Immunol. 2021 Jul;127(1):19-27
pubmed: 33716149
PLoS One. 2013 Oct 24;8(10):e76520
pubmed: 24204633
Diabetologia. 2017 Sep;60(9):1662-1667
pubmed: 28770326
Science. 2016 Apr 29;352(6285):544-5
pubmed: 27126037
Front Immunol. 2021 Feb 05;11:622114
pubmed: 33613556
Front Immunol. 2022 Feb 17;13:742530
pubmed: 35250968
Nat Rev Immunol. 2013 May;13(5):321-35
pubmed: 23618829
Pol J Microbiol. 2018;67(3):251-258
pubmed: 30451441
J Paediatr Child Health. 2007 Dec;43(12):837-42
pubmed: 17803667
Front Pediatr. 2015 Mar 05;3:17
pubmed: 25798435
Cell. 2016 Nov 17;167(5):1339-1353.e21
pubmed: 27863247
Sci Transl Med. 2016 May 18;8(339):339ra71
pubmed: 27194729
Clin Exp Immunol. 2019 Jan;195(1):74-85
pubmed: 29920643
Eur J Clin Nutr. 2008 Mar;62(3):332-5
pubmed: 17311052
Nat Rev Gastroenterol Hepatol. 2017 Aug;14(8):491-502
pubmed: 28611480
Immunity. 2013 Aug 22;39(2):372-85
pubmed: 23973224
Trends Microbiol. 2016 Jun;24(6):463-476
pubmed: 26897710
BMC Infect Dis. 2015 Apr 17;15:191
pubmed: 25885020
Science. 2018 Jan 5;359(6371):91-97
pubmed: 29097494
Am J Gastroenterol. 2022 Nov 1;117(11):1743-1752
pubmed: 36148549
F1000Res. 2019 May 21;8:699
pubmed: 32704349
Circulation. 2016 Jun 14;133(24):2434-46
pubmed: 27143680
Front Immunol. 2016 Sep 20;7:365
pubmed: 27703456
J Appl Bacteriol. 1993 Oct;75(4):373-80
pubmed: 8226394
Genome Med. 2016 Apr 21;8(1):45
pubmed: 27102333
Gastroenterology. 2015 Jul;149(1):102-109.e6
pubmed: 25857665
J Immunol. 2019 Feb 1;202(3):956-965
pubmed: 30617224
Medicine (Baltimore). 2016 Aug;95(31):e4509
pubmed: 27495104
J Clin Gastroenterol. 2019 Mar;53 Suppl 1:S1-S41
pubmed: 30741841
Diabetes Metab J. 2015 Jun;39(3):198-203
pubmed: 26124989
Aliment Pharmacol Ther. 2013 Sep;38(5):467-76
pubmed: 23841880
World J Gastroenterol. 2019 May 14;25(18):2188-2203
pubmed: 31143070
Br J Nutr. 2015 Dec;114 Suppl 1:S1-15
pubmed: 26548336
Am J Physiol Heart Circ Physiol. 2020 Jun 1;318(6):H1474-H1486
pubmed: 32330092
Curr Drug Metab. 2016;17(2):187-93
pubmed: 26806042
J Clin Immunol. 2018 Jan;38(1):96-128
pubmed: 29226302
Clin Exp Allergy. 2007 Apr;37(4):498-505
pubmed: 17430345
Gut. 2003 Jul;52(7):988-97
pubmed: 12801956
World J Gastroenterol. 2010 May 14;16(18):2202-22
pubmed: 20458757
Clin Endosc. 2021 Mar;54(2):152-156
pubmed: 33761228
Br J Nutr. 2009 Feb;101(4):541-50
pubmed: 18590586
Eur J Clin Nutr. 2002 Dec;56 Suppl 4:S50-5
pubmed: 12556948
J Infect Chemother. 2015 Apr;21(4):230-7
pubmed: 25703532
J Anim Sci Biotechnol. 2021 Jun 16;12(1):71
pubmed: 34130737
Sci Rep. 2016 Mar 21;6:23522
pubmed: 26997149
Curr Opin Gastroenterol. 2018 Jul;34(4):217-225
pubmed: 29762159
Immun Ageing. 2019 Mar 08;16:6
pubmed: 30899315
Nat Commun. 2020 Aug 28;11(1):4333
pubmed: 32859933
Cells. 2020 Jun 19;9(6):
pubmed: 32575504
BMC Immunol. 2008 Jun 13;9:27
pubmed: 18554392
Front Immunol. 2020 Apr 09;11:645
pubmed: 32328074
Aliment Pharmacol Ther. 2015 Jul;42(2):158-79
pubmed: 26011307
J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):38-59
pubmed: 26563668
Can J Gastroenterol Hepatol. 2018 Sep 2;2018:1394379
pubmed: 30246002
J Autoimmun. 2011 Feb;36(1):25-32
pubmed: 21075598
Nat Med. 2021 Feb;27(2):333-343
pubmed: 33574608
Drug Res (Stuttg). 2017 Dec;67(12):724-729
pubmed: 28898911
Immunity. 2014 Jan 16;40(1):128-39
pubmed: 24412617
J Clin Periodontol. 2020 Feb;47(2):202-212
pubmed: 31674689
Front Microbiol. 2018 Aug 24;9:1995
pubmed: 30197637
Pediatr Res. 1992 Aug;32(2):141-4
pubmed: 1324462
Nat Rev Gastroenterol Hepatol. 2014 Aug;11(8):506-14
pubmed: 24912386
Nature. 2013 Dec 19;504(7480):446-50
pubmed: 24226770
Int J Food Microbiol. 2010 Jul 31;141 Suppl 1:S53-9
pubmed: 20447709
Nat Microbiol. 2019 Jan;4(1):35-45
pubmed: 30546094
Rev Alerg Mex. 2013 Jul-Sep;60(3):110-6
pubmed: 24274606
Int J Mol Med. 2012 Feb;29(2):202-8
pubmed: 22089663
Curr Gastroenterol Rep. 2016 Apr;18(4):17
pubmed: 26951230
Proc Natl Acad Sci U S A. 2013 May 28;110(22):9066-71
pubmed: 23671105
Front Immunol. 2021 Aug 02;12:712915
pubmed: 34408753
J Transl Med. 2017 Apr 8;15(1):73
pubmed: 28388917
Adv Food Nutr Res. 2009;56:1-15
pubmed: 19389605
Br J Nutr. 2009 Oct;102(8):1154-60
pubmed: 19445821
Front Immunol. 2020 Sep 16;11:574500
pubmed: 33042155
J Biol Regul Homeost Agents. 2015 Apr-Jun;29(2 Suppl 1):96-113
pubmed: 26634595
Pathogens. 2019 Aug 13;8(3):
pubmed: 31412603
J Clin Immunol. 2005 May;25(3):275-80
pubmed: 15981093
Lancet. 2017 Mar 25;389(10075):1218-1228
pubmed: 28214091
Pediatr Surg Int. 2002 Oct;18(7):586-90
pubmed: 12471471
Nutrients. 2017 May 24;9(6):
pubmed: 28538698
Clin Exp Immunol. 2013 May;172(2):321-32
pubmed: 23574328
Biosci Biotechnol Biochem. 2013;77(7):1372-8
pubmed: 23832328
Cochrane Database Syst Rev. 2010 Nov 10;(11):CD003048
pubmed: 21069673