Autoimmunity in common variable immunodeficiency.
Journal
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
ISSN: 1534-4436
Titre abrégé: Ann Allergy Asthma Immunol
Pays: United States
ID NLM: 9503580
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
31
05
2019
revised:
15
07
2019
accepted:
16
07
2019
pubmed:
28
7
2019
medline:
10
3
2020
entrez:
27
7
2019
Statut:
ppublish
Résumé
Common variable immunodeficiency (CVID) is a primary immunodeficiency that is clinically heterogeneous, characterized by both infectious and noninfectious complications. Although the hallmark of disease presentation is commonly a history of recurrent sinopulmonary infections, autoimmunity and noninfectious inflammatory conditions are increasingly associated with CVID. A comprehensive literature search using PubMed of basic science and clinical articles was performed. Articles discussing the association of autoimmunity with primary immunodeficiency, specifically CVID, were selected. The most common autoimmune conditions are cytopenias, including immune thrombocytopenia purpura and hemolytic anemia, but organ-specific autoimmune/inflammatory complications involving the gastrointestinal, skin, joints, connective tissue, and respiratory tract. In most cases, immunoglobulin replacement therapy does not ameliorate or treat these inflammatory complications, and additional immunomodulatory treatments are needed. Mechanisms producing these conditions are poorly understood but include cytokine and cellular inflammatory pathways, and loss of tolerance to self-antigens through the multiple signaling molecules and pathways common to tolerance and immune deficiency.
Identifiants
pubmed: 31349011
pii: S1081-1206(19)30532-0
doi: 10.1016/j.anai.2019.07.014
pmc: PMC7310570
mid: NIHMS1599295
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
454-460Subventions
Organisme : NIAID NIH HHS
ID : P01 AI061093
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
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