Radiation-induced optic neuropathy after stereotactic and image guided intensity-modulated radiation therapy (IMRT).
Adolescent
Adult
Aged
Aged, 80 and over
Child
Female
Glioblastoma
/ radiotherapy
Head and Neck Neoplasms
/ radiotherapy
Humans
Male
Meningeal Neoplasms
/ radiotherapy
Meningioma
/ radiotherapy
Middle Aged
Neoplasms
/ radiotherapy
Optic Nerve
/ radiation effects
Optic Nerve Diseases
/ etiology
Radiation Injuries
/ etiology
Radiosurgery
/ adverse effects
Radiotherapy Planning, Computer-Assisted
/ methods
Radiotherapy, Image-Guided
/ adverse effects
Radiotherapy, Intensity-Modulated
/ adverse effects
Retrospective Studies
Squamous Cell Carcinoma of Head and Neck
/ radiotherapy
Visual Pathways
/ radiation effects
Young Adult
IMRT-image-guided/stereotactic repositioning
RION
Radiation-induced optic neuropathy
Radiation-induced toxicity
Treatment-related toxicity
Journal
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
ISSN: 1879-0887
Titre abrégé: Radiother Oncol
Pays: Ireland
ID NLM: 8407192
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
13
01
2019
accepted:
03
02
2019
entrez:
22
4
2019
pubmed:
22
4
2019
medline:
28
3
2020
Statut:
ppublish
Résumé
To quantify the risk of radiation-induced optic neuropathy (RION) after stereotactic/image-guided positioning and intensity-modulated radiotherapy (IMRT) with ≥50 Gy to the anterior visual pathway (AVP). Patients irradiated with ≥50 Gy to the AVP using stereotactic/image-guided positioning between 2002 and 2011 in Mannheim were identified. Detailed dosimetric data were collected and patients or family members were retrospectively asked to rate visual acuity and visual disorders. 125 patients fulfilled the eligibility criteria. Average maximum equivalent point dose (D Risk of RION was low in this cohort with accurate positioning and precise dosimetric information. Less conservative tolerance doses may be considered in patients with high risk of recurrence.
Sections du résumé
BACKGROUND/PURPOSE
To quantify the risk of radiation-induced optic neuropathy (RION) after stereotactic/image-guided positioning and intensity-modulated radiotherapy (IMRT) with ≥50 Gy to the anterior visual pathway (AVP).
METHODS
Patients irradiated with ≥50 Gy to the AVP using stereotactic/image-guided positioning between 2002 and 2011 in Mannheim were identified. Detailed dosimetric data were collected and patients or family members were retrospectively asked to rate visual acuity and visual disorders.
RESULTS
125 patients fulfilled the eligibility criteria. Average maximum equivalent point dose (D
CONCLUSION
Risk of RION was low in this cohort with accurate positioning and precise dosimetric information. Less conservative tolerance doses may be considered in patients with high risk of recurrence.
Identifiants
pubmed: 31005211
pii: S0167-8140(19)30069-6
doi: 10.1016/j.radonc.2019.02.003
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
166-177Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.