Protective effect of the antioxidative peptide SS31 on ionizing radiation-induced hematopoietic system damage in mice.
Animals
Antioxidants
/ pharmacology
DNA Damage
/ drug effects
Disease Models, Animal
Hematopoiesis
/ drug effects
Hematopoietic Stem Cells
/ drug effects
Male
Mice
Mitochondria
/ drug effects
Oligopeptides
/ pharmacology
Oxidative Stress
/ drug effects
Radiation Dosage
Radiation Injuries, Experimental
/ blood
Radiation, Ionizing
Reactive Oxygen Species
/ metabolism
Stem Cells
Survival Rate
Whole-Body Irradiation
Hematopoietic system
Ionizing radiation
Reactive oxygen species
SS31
Journal
Blood cells, molecules & diseases
ISSN: 1096-0961
Titre abrégé: Blood Cells Mol Dis
Pays: United States
ID NLM: 9509932
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
15
01
2019
revised:
05
04
2019
accepted:
05
04
2019
pubmed:
22
4
2019
medline:
15
1
2020
entrez:
22
4
2019
Statut:
ppublish
Résumé
Ionizing radiation (IR) causes severe damage to the hematopoietic system; thus, it is necessary to explore agents or compounds that can reduce this damage. SS31 is a mitochondria-targeted peptide that can scavenge cellular reactive oxygen species (ROS) and inhibit the production of mitochondrial ROS. Therefore, in this study, we discuss the protective effect of SS31 on IR-induced hematopoietic system damage. Our results showed that treatment with 6 mg/kg SS31 elevated the survival rate of lethally irradiated mice and increased the numbers of white blood cells, red blood cells, hemoglobin and platelets in mice exposed to 4 Gy whole-body irradiation. In addition, SS31 administration improved the number of hematopoietic stem/progenitor cells (HSPCs) and the self-renewal and reconstitution abilities of these cells in irradiated mice. The elevation of ROS levels is the main cause of IR-induced hematopoietic system damage, and SS31 can effectively reduce the ROS level in HSPCs. The above results suggest that SS31 can protect the hematopoietic system from radiation-induced damage by reducing cellular ROS levels.
Identifiants
pubmed: 31005751
pii: S1079-9796(19)30017-8
doi: 10.1016/j.bcmd.2019.04.001
pii:
doi:
Substances chimiques
Antioxidants
0
Oligopeptides
0
Reactive Oxygen Species
0
arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
82-87Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.