Phytosterol biosynthesis and production by diatoms (Bacillariophyceae).
Biosynthesis
Diatoms
Metabolites
Phytosterols
Secondary metabolism
Journal
Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
26
07
2018
revised:
22
03
2019
accepted:
22
03
2019
pubmed:
22
4
2019
medline:
7
8
2019
entrez:
22
4
2019
Statut:
ppublish
Résumé
Diatoms are abundant unicellular marine photosynthetic algae that have genetically diversified their physiology and metabolism while adapting to numerous environments. The metabolic repertoire of diatoms presents opportunities to characterise the biosynthesis and production of new and potentially valuable microalgal compounds, including sterols. Sterols of plant origin, known as phytosterols, have been studied for health benefits including demonstrated cholesterol-lowering properties. In this review we summarise sterol diversity, the unique metabolic features of sterol biosynthesis in diatoms, and prospects for the extraction of diatom phytosterols in comparison to existing sources. We also review biotechnological efforts to manipulate diatom biosynthesis, including culture conditions and avenues for the rational engineering of metabolism and cellular regulation.
Identifiants
pubmed: 31005802
pii: S0031-9422(18)30369-8
doi: 10.1016/j.phytochem.2019.03.018
pii:
doi:
Substances chimiques
Phytosterols
0
Types de publication
Journal Article
Review
Langues
eng
Pagination
46-57Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.