Immune Activation and Microbial Translocation Markers in HIV-Exposed Uninfected Malawian Infants in the First Year of Life.
Acute-Phase Proteins
Anti-Retroviral Agents
/ therapeutic use
Bacterial Translocation
Biomarkers
/ blood
Carrier Proteins
/ blood
Fatty Acid-Binding Proteins
/ blood
Female
Gastrointestinal Diseases
Growth Disorders
/ blood
HIV Infections
/ drug therapy
Humans
Infant
Infant Nutrition Disorders
/ blood
Lipopolysaccharide Receptors
/ blood
Malawi
Male
Membrane Glycoproteins
/ blood
Pregnancy
Pregnancy Complications, Infectious
/ drug therapy
HIV-exposed infants
intestinal biomarkers
malnutrition
Journal
Journal of tropical pediatrics
ISSN: 1465-3664
Titre abrégé: J Trop Pediatr
Pays: England
ID NLM: 8010948
Informations de publication
Date de publication:
01 12 2019
01 12 2019
Historique:
pubmed:
22
4
2019
medline:
1
7
2020
entrez:
22
4
2019
Statut:
ppublish
Résumé
HIV-exposed uninfected (HEU) infants show a high rate of morbidity. We aimed to investigate on biomarkers of immune activation/microbial translocation in HEU infants, evaluating the impact that infections/malnutrition can have on biomarker levels during the first year of life. Clinical data of 72 Malawian infants were recorded monthly and correlated with levels of soluble CD14 (sCD14), lipopolysaccharide-binding protein (LBP) and intestinal fatty acid-binding protein (I-FABP), analyzed longitudinally. Levels of sCD14 and LBP showed a significant age-related increase. Higher levels of LBP (19.4 vs. 15.2 μg/ml) were associated with stunting, affecting 30% of the infants. The association remained statistically significant after adjusting for cytomegalovirus acquisition, malaria and respiratory infections (p = 0.031). I-FABP levels were significantly increased in infants experiencing gastrointestinal infections (1442.8 vs. 860.0 pg/ml, p = 0.018). We provide evidence that stunting is associated with an enhanced inflammatory response to microbial products in HEU children, suggesting that malnutrition status should be taken into consideration to better understand the alteration of the immune profile of HEU infants living in poor socioeconomic settings.
Sections du résumé
BACKGROUND
HIV-exposed uninfected (HEU) infants show a high rate of morbidity. We aimed to investigate on biomarkers of immune activation/microbial translocation in HEU infants, evaluating the impact that infections/malnutrition can have on biomarker levels during the first year of life.
METHODS
Clinical data of 72 Malawian infants were recorded monthly and correlated with levels of soluble CD14 (sCD14), lipopolysaccharide-binding protein (LBP) and intestinal fatty acid-binding protein (I-FABP), analyzed longitudinally.
RESULTS
Levels of sCD14 and LBP showed a significant age-related increase. Higher levels of LBP (19.4 vs. 15.2 μg/ml) were associated with stunting, affecting 30% of the infants. The association remained statistically significant after adjusting for cytomegalovirus acquisition, malaria and respiratory infections (p = 0.031). I-FABP levels were significantly increased in infants experiencing gastrointestinal infections (1442.8 vs. 860.0 pg/ml, p = 0.018).
CONCLUSION
We provide evidence that stunting is associated with an enhanced inflammatory response to microbial products in HEU children, suggesting that malnutrition status should be taken into consideration to better understand the alteration of the immune profile of HEU infants living in poor socioeconomic settings.
Identifiants
pubmed: 31006009
pii: 5475883
doi: 10.1093/tropej/fmz022
doi:
Substances chimiques
Acute-Phase Proteins
0
Anti-Retroviral Agents
0
Biomarkers
0
Carrier Proteins
0
Fatty Acid-Binding Proteins
0
Lipopolysaccharide Receptors
0
Membrane Glycoproteins
0
lipopolysaccharide-binding protein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
617-625Informations de copyright
© The Author(s) [2019]. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.