The effect of peripheral blood eosinophilia on inflammatory markers in asthmatic patients with lower respiratory tract infections.
Asthma
/ diagnosis
Biomarkers
/ metabolism
C-Reactive Protein
/ metabolism
Cross-Sectional Studies
Disease Progression
Eosinophilia
/ complications
Female
Follow-Up Studies
Humans
Inflammation
/ complications
Inflammation Mediators
/ metabolism
Lymphocytes
/ pathology
Male
Neutrophils
/ pathology
Predictive Value of Tests
Respiratory Tract Infections
/ diagnosis
Retrospective Studies
Lower respiratory tract infection
allergic asthma
neutrophil-to-lymphocyte ratio
peripheral blood eosinophilia
Journal
The Journal of international medical research
ISSN: 1473-2300
Titre abrégé: J Int Med Res
Pays: England
ID NLM: 0346411
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
pubmed:
23
4
2019
medline:
18
12
2019
entrez:
23
4
2019
Statut:
ppublish
Résumé
To investigate the behaviour of the inflammatory marker neutrophil-to-lymphocyte ratio (NLR) in the presence of peripheral blood eosinophilia (PBE) in paediatric asthma patients with lower respiratory tract (LRT) infections. This retrospective study enrolled consecutive patients aged ≥5 years who were diagnosed with asthma and whose haemogram values were available. The patients were further subdivided based on the presence or absence of LRT infections and allergies. NLR and C-reactive protein (CRP) were evaluated in relation to the presence or absence of PBE (≥4% eosinophils). A total of 991 patients were enrolled in the study. Patients with LRT infections had significantly higher leucocyte and neutrophil counts, a greater NLR and a higher level of CRP compared with patients without LRT infections. Overall, patients with PBE had significantly lower NLRs and CRP regardless of the presence or absence of an LRT infection. The PBE percentage showed moderate inverse correlations with NLR ( r = -0.34) and CRP ( r = -0.20). The presence of PBE was significantly associated with lower NLR and CRP regardless of the presence or absence of an infectious condition.
Sections du résumé
BACKGROUND
BACKGROUND
To investigate the behaviour of the inflammatory marker neutrophil-to-lymphocyte ratio (NLR) in the presence of peripheral blood eosinophilia (PBE) in paediatric asthma patients with lower respiratory tract (LRT) infections.
METHODS
METHODS
This retrospective study enrolled consecutive patients aged ≥5 years who were diagnosed with asthma and whose haemogram values were available. The patients were further subdivided based on the presence or absence of LRT infections and allergies. NLR and C-reactive protein (CRP) were evaluated in relation to the presence or absence of PBE (≥4% eosinophils).
RESULTS
RESULTS
A total of 991 patients were enrolled in the study. Patients with LRT infections had significantly higher leucocyte and neutrophil counts, a greater NLR and a higher level of CRP compared with patients without LRT infections. Overall, patients with PBE had significantly lower NLRs and CRP regardless of the presence or absence of an LRT infection. The PBE percentage showed moderate inverse correlations with NLR ( r = -0.34) and CRP ( r = -0.20).
CONCLUSION
CONCLUSIONS
The presence of PBE was significantly associated with lower NLR and CRP regardless of the presence or absence of an infectious condition.
Identifiants
pubmed: 31006357
doi: 10.1177/0300060519844859
pmc: PMC6567716
doi:
Substances chimiques
Biomarkers
0
Inflammation Mediators
0
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
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