A comparison of risk factors for metastasis at diagnosis in humans and dogs with osteosarcoma.
dog
human
metastasis
osteosarcoma
Journal
Cancer medicine
ISSN: 2045-7634
Titre abrégé: Cancer Med
Pays: United States
ID NLM: 101595310
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
07
02
2019
revised:
28
03
2019
accepted:
04
04
2019
pubmed:
23
4
2019
medline:
8
7
2020
entrez:
23
4
2019
Statut:
ppublish
Résumé
Canine osteosarcoma (OS) is a relevant spontaneous model for human OS. Identifying similarities in clinical characteristics associated with metastasis at diagnosis in both species may substantiate research aimed at using canine OS as a model for identifying mechanisms driving distant spread in the human disease. This retrospective study included dog OS cases from three academic veterinary hospitals and human OS cases from the Surveillance, Epidemiology, and End Results program. Associations between clinical factors and metastasis at diagnosis were estimated using logistic regression models. In humans, those with trunk tumors had higher odds of metastasis at diagnosis compared to those with lower limb tumors (OR = 2.38, 95% CI: 1.51, 3.69). A similar observation was seen in dogs with trunk tumors compared to dogs with forelimb tumors (OR = 3.28, 95% CI 1.36, 7.50). Other associations were observed in humans but not in dogs. Humans aged 20-29 years had lower odds of metastasis at diagnosis compared to those aged 10-14 years (OR = 0.67, 95% CI: 0.47, 0.96); every 1-cm increase in tumor size was associated with a 6% increase in the odds of metastasis at diagnosis (95% CI: 1.04, 1.08); compared to those with a white, non-Hispanic race, higher odds were observed among those with a black, non-Hispanic race (OR: 1.51, 95% CI: 1.04, 2.16), and those with a Hispanic origin (OR 1.35, 95% CI: 1.00, 1.81). A common mechanism may be driving trunk tumors to progress to detectable metastasis prior to diagnosis in both species.
Sections du résumé
BACKGROUND
Canine osteosarcoma (OS) is a relevant spontaneous model for human OS. Identifying similarities in clinical characteristics associated with metastasis at diagnosis in both species may substantiate research aimed at using canine OS as a model for identifying mechanisms driving distant spread in the human disease.
METHODS
This retrospective study included dog OS cases from three academic veterinary hospitals and human OS cases from the Surveillance, Epidemiology, and End Results program. Associations between clinical factors and metastasis at diagnosis were estimated using logistic regression models.
RESULTS
In humans, those with trunk tumors had higher odds of metastasis at diagnosis compared to those with lower limb tumors (OR = 2.38, 95% CI: 1.51, 3.69). A similar observation was seen in dogs with trunk tumors compared to dogs with forelimb tumors (OR = 3.28, 95% CI 1.36, 7.50). Other associations were observed in humans but not in dogs. Humans aged 20-29 years had lower odds of metastasis at diagnosis compared to those aged 10-14 years (OR = 0.67, 95% CI: 0.47, 0.96); every 1-cm increase in tumor size was associated with a 6% increase in the odds of metastasis at diagnosis (95% CI: 1.04, 1.08); compared to those with a white, non-Hispanic race, higher odds were observed among those with a black, non-Hispanic race (OR: 1.51, 95% CI: 1.04, 2.16), and those with a Hispanic origin (OR 1.35, 95% CI: 1.00, 1.81).
CONCLUSION
A common mechanism may be driving trunk tumors to progress to detectable metastasis prior to diagnosis in both species.
Identifiants
pubmed: 31006987
doi: 10.1002/cam4.2177
pmc: PMC6558582
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3216-3226Subventions
Organisme : NCI NIH HHS
ID : R21 CA208529
Pays : United States
Organisme : NIAMS NIH HHS
ID : T32 AR050938
Pays : United States
Informations de copyright
© 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
Références
J Comp Pathol. 2007 Jan;136(1):65-73
pubmed: 17270206
Cancer Causes Control. 2011 Jun;22(6):899-908
pubmed: 21465145
Surg Oncol. 2010 Dec;19(4):193-9
pubmed: 19515554
Vet Comp Oncol. 2011 Jun;9(2):131-40
pubmed: 21569198
J Bone Miner Res. 2010 Apr;25(4):683-91
pubmed: 20205169
J Clin Oncol. 1993 Mar;11(3):449-53
pubmed: 8445419
Vet Radiol Ultrasound. 2012 May-Jun;53(3):273-9
pubmed: 22413965
Trends Mol Med. 2011 Jul;17(7):380-8
pubmed: 21439907
Vet J. 1998 Jul;156(1):31-9
pubmed: 9691849
J Am Vet Med Assoc. 1992 Apr 1;200(7):995-9
pubmed: 1577656
J Am Vet Med Assoc. 1982 Apr 15;180(8):927-33
pubmed: 6953063
J Am Vet Med Assoc. 2007 Oct 1;231(7):1076-80
pubmed: 17916033
Vet Sci. 2016 Jan 18;3(1):
pubmed: 29056713
Vet J. 2011 Sep;189(3):268-77
pubmed: 20889358
Orphanet J Rare Dis. 2013 Jan 11;8:7
pubmed: 23311495
Vet Clin North Am Small Anim Pract. 2003 May;33(3):491-516, vi
pubmed: 12852233
Cancer Discov. 2015 Sep;5(9):920-31
pubmed: 26084801
Vet Surg. 2017 Jan;46(1):75-80
pubmed: 27906470
Nat Rev Cancer. 2003 Jun;3(6):453-8
pubmed: 12778135
J Clin Oncol. 2002 Feb 1;20(3):776-90
pubmed: 11821461
Ann Surg Oncol. 2004 Nov;11(11):998-1004
pubmed: 15525829
J Gerontol A Biol Sci Med Sci. 1997 May;52(3):B171-8
pubmed: 9158552
Cancer. 2009 Apr 1;115(7):1531-43
pubmed: 19197972
Radiology. 1988 Sep;168(3):679-93
pubmed: 3043546
Cancer Epidemiol. 2011 Feb;35(1):83-9
pubmed: 20685192
Clin Epidemiol. 2013 May 16;5:147-62
pubmed: 23700373
J Natl Cancer Inst. 1970 Jan;44(1):187-99
pubmed: 11515030
Bone. 2011 Sep;49(3):356-67
pubmed: 21621658
J Am Anim Hosp Assoc. 1995 Jul-Aug;31(4):321-6
pubmed: 7552665
J Pediatr. 1991 Nov;119(5):725-32
pubmed: 1941378
Cancer Med. 2019 Jun;8(6):3216-3226
pubmed: 31006987
Acta Paediatr. 2015 Jul;104(7):738-45
pubmed: 25721807
J Surg Oncol. 1999 Nov;72(3):124-9
pubmed: 10562357
Vet Comp Oncol. 2015 Mar;13(1):28-39
pubmed: 23421618
Arch Dis Child. 2013 May;98(5):349-55
pubmed: 23476000
J Biol Chem. 2015 Nov 20;290(47):28070-83
pubmed: 26378234
Clin Orthop Relat Res. 1991 Sep;(270):159-68
pubmed: 1884536
J Clin Oncol. 2003 Jan 15;21(2):334-41
pubmed: 12525527
Vet Sci. 2015 Aug 17;2(3):210-230
pubmed: 29061942
J Bone Joint Surg Am. 2013 Jul 3;95(13):e89
pubmed: 23824394
Cancer. 2018 Oct 15;124(20):4090-4097
pubmed: 30125340
ILAR J. 2014;55(1):69-85
pubmed: 24936031
Dis Model Mech. 2016 Dec 1;9(12):1435-1444
pubmed: 27874835
Pediatr Blood Cancer. 2016 Jun;63(6):1006-11
pubmed: 26929018
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
Vet Radiol Ultrasound. 2002 Sep-Oct;43(5):432-41
pubmed: 12375777
Nat Genet. 2015 Jun;47(6):615-24
pubmed: 25961939
Cancer Causes Control. 2007 Mar;18(2):177-87
pubmed: 17219013
Eur J Cancer. 2004 Oct;40(15):2280-6
pubmed: 15454254
Cancer. 2005 Sep 1;104(5):1100-9
pubmed: 16015627
Acta Oncol. 2015 Jan;54(1):25-33
pubmed: 24957555
Vet Radiol Ultrasound. 2008 Sep-Oct;49(5):432-7
pubmed: 18833949
Cancer. 1999 Oct 15;86(8):1602-8
pubmed: 10526292
Cancer Res. 2018 Jan 15;78(2):326-337
pubmed: 29066513
Cancer Res. 2005 Jul 1;65(13):5654-61
pubmed: 15994938
Vet Surg. 1992 Jul-Aug;21(4):304-10
pubmed: 1455640
Am J Public Health. 2000 Aug;90(8):1212-5
pubmed: 10936998
Sarcoma. 2011;2011:548151
pubmed: 21437228
Science. 2014 Oct 10;346(6206):251-6
pubmed: 25301630
J Surg Oncol. 2008 Nov 1;98(6):415-20
pubmed: 18792969
J Small Anim Pract. 2007 Mar;48(3):145-50
pubmed: 17355605
Eur J Cancer. 1997 Oct;33(11):1725-31
pubmed: 9470825