Animal models of drug-induced liver injury.
Acetaminophen
Carbon tetrachloride
Idiosyncratic hepatotoxicity
Immune tolerance
Intrinsic hepatotoxicity
Journal
Biochimica et biophysica acta. Molecular basis of disease
ISSN: 1879-260X
Titre abrégé: Biochim Biophys Acta Mol Basis Dis
Pays: Netherlands
ID NLM: 101731730
Informations de publication
Date de publication:
01 05 2019
01 05 2019
Historique:
received:
25
07
2018
revised:
18
08
2018
accepted:
28
08
2018
entrez:
23
4
2019
pubmed:
23
4
2019
medline:
28
11
2019
Statut:
ppublish
Résumé
Drug-induced liver injury (DILI) presents unique challenges for consumers, clinicians, and regulators. It is the most common cause of acute liver failure in the US. It is also one of the most common reasons for termination of new drugs during pre-clinical testing and withdrawal of new drugs post-marketing. DILI is generally divided into two forms: intrinsic and idiosyncratic. Many of the challenges with DILI are due in large part to poor understanding of the mechanisms of toxicity. Although useful models of intrinsic DILI are available, they are frequently misused. Modeling idiosyncratic DILI presents greater challenges, but promising new models have recently been developed. The purpose of this manuscript is to provide a critical review of the most popular animal models of DILI, and to discuss the future of DILI research.
Identifiants
pubmed: 31007174
pii: S0925-4439(18)30330-2
doi: 10.1016/j.bbadis.2018.08.037
pmc: PMC6478394
mid: NIHMS1510480
pii:
doi:
Substances chimiques
Acetaminophen
362O9ITL9D
Carbon Tetrachloride
CL2T97X0V0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1031-1039Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103549
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM118247
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK102142
Pays : United States
Organisme : NCATS NIH HHS
ID : U54 TR001629
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.
Références
Drug Metab Rev. 2012 Feb;44(1):88-106
pubmed: 22229890
Toxicol Appl Pharmacol. 2014 Sep 15;279(3):266-274
pubmed: 24905542
Toxicol Appl Pharmacol. 2009 Jul 15;238(2):150-9
pubmed: 19442681
Toxicology. 2008 Jan 20;243(3):249-60
pubmed: 18078705
Expert Opin Drug Saf. 2018 Feb;17(2):117-123
pubmed: 29215916
Pharmacol Rev. 2013 Mar 08;65(2):779-808
pubmed: 23476052
Toxicol Appl Pharmacol. 2012 Nov 1;264(3):387-94
pubmed: 22980195
Toxicol Sci. 2018 Feb 1;161(2):412-420
pubmed: 29087505
J Biol Chem. 2008 May 16;283(20):13565-77
pubmed: 18337250
Lab Invest. 2012 Mar;92(3):396-410
pubmed: 22157718
J Pharmacol Exp Ther. 1990 Dec;255(3):935-41
pubmed: 2262912
Xenobiotica. 2015 May;45(5):442-9
pubmed: 25423287
Clin Exp Pharmacol Physiol. 2013 Jul;40(7):422-30
pubmed: 23611112
Gastroenterology. 1992 Feb;102(2):577-86
pubmed: 1732127
J Clin Pharmacol. 2001 Aug;41(8):846-51
pubmed: 11504272
Gastroenterology. 2017 Apr;152(5):1078-1089
pubmed: 28043905
Br J Pharmacol Chemother. 1966 Mar;26(3):606-14
pubmed: 5959211
Gastroenterology. 2008 Oct;135(4):1311-21
pubmed: 18700144
Liver Int. 2012 Jan;32(1):8-20
pubmed: 21745276
JAMA. 2006 Jul 5;296(1):87-93
pubmed: 16820551
Pediatrics. 2006 Sep;118(3):e676-81
pubmed: 16950959
Toxicol Appl Pharmacol. 1988 May;93(3):378-87
pubmed: 3368917
Food Chem Toxicol. 2013 Aug;58:228-35
pubmed: 23628456
Free Radic Biol Med. 2006 Feb 1;40(3):420-9
pubmed: 16443156
Mol Pharmacol. 2012 Nov;82(5):1001-7
pubmed: 22918968
Hepatology. 2011 Mar;53(3):974-82
pubmed: 21319200
J Hepatol. 2018 Aug;69(2):385-395
pubmed: 29572095
Hepatology. 2007 Jun;45(6):1588-9; author reply 1589
pubmed: 17539019
Acta Pharmacol Toxicol (Copenh). 1964;21:197-204
pubmed: 14203053
J Immunotoxicol. 2015 Jul-Sep;12(3):247-60
pubmed: 25046026
J Pharmacol Exp Ther. 1977 Feb;200(2):439-48
pubmed: 839448
Arch Toxicol. 2017 Feb;91(2):761-773
pubmed: 27002509
J Clin Transl Res. 2017 Feb;3(Suppl 1):170-188
pubmed: 28670626
Toxicol Appl Pharmacol. 1975 Oct;34(1):102-14
pubmed: 1198608
Cell Death Dis. 2014 Jan 09;5:e989
pubmed: 24407242
J Clin Transl Res. 2018 May 28;4(1):75-100
pubmed: 30873497
Can J Physiol Pharmacol. 2010 Oct;88(10):960-7
pubmed: 20962895
Toxicol Appl Pharmacol. 1997 Dec;147(2):300-11
pubmed: 9439725
Hepatology. 2008 Jun;47(6):2003-9
pubmed: 18454504
Toxicol Pathol. 2009 Feb;37(2):193-200
pubmed: 19332662
BMC Med. 2016 Feb 04;14:10
pubmed: 26843061
Toxicol Appl Pharmacol. 2010 Jul;246(1-2):8-17
pubmed: 20423716
Food Chem Toxicol. 2015 Dec;86:253-61
pubmed: 26522885
J Clin Transl Hepatol. 2014 Sep;2(3):153-61
pubmed: 26355817
Chem Res Toxicol. 2011 Jun 20;24(6):794-6
pubmed: 21557537
Hepatology. 2014 Oct;60(4):1336-45
pubmed: 24923598
Hepatology. 2015 Apr;61(4):1332-42
pubmed: 25283142
Cell Metab. 2015 Sep 1;22(3):472-84
pubmed: 26256392
Hepatology. 2012 Nov;56(5):1971-82
pubmed: 22532075
J Pharmacol Exp Ther. 2003 Oct;307(1):9-16
pubmed: 12893837
Clin Sci Mol Med. 1975 Nov;49(5):495-502
pubmed: 1192708
J Clin Invest. 2012 Apr;122(4):1574-83
pubmed: 22378043
Toxicol Lett. 2014 Mar 21;225(3):445-53
pubmed: 24440347
Hepatology. 2015 Dec;62(6):1847-57
pubmed: 26077809
Expert Rev Mol Diagn. 2018 Sep;18(9):797-807
pubmed: 30080986
Hepatology. 2010 Jul;52(1):303-12
pubmed: 20578157
Toxicol Appl Pharmacol. 2015 Dec 1;289(2):213-22
pubmed: 26431796
Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1269-79
pubmed: 16439473
Clin Pharmacol Ther. 2017 Apr;101(4):469-480
pubmed: 27861792
Chem Biol Interact. 2010 Oct 6;188(1):204-13
pubmed: 20655887
Expert Opin Drug Metab Toxicol. 2015;11(11):1769-79
pubmed: 26190663
Toxicol Sci. 2007 May;97(1):205-13
pubmed: 17150972
Crit Rev Toxicol. 2003;33(2):105-36
pubmed: 12708612
Hepatology. 1985 Nov-Dec;5(6):1179-82
pubmed: 2933316
Hepatology. 2012 Jan;55(1):222-32
pubmed: 21932416
J Pharmacol Exp Ther. 2006 Dec;319(3):1191-9
pubmed: 16990511
Nature. 1966 Jan 1;209(5018):36-40
pubmed: 5925327
Biochem Pharmacol. 1987 Jan 1;36(1):51-7
pubmed: 3801056
Lab Invest. 2008 Oct;88(10):1068-78
pubmed: 18679376
Food Chem Toxicol. 2018 May;115:273-283
pubmed: 29534981
J Pharm Pharmacol. 1978 Jun;30(6):375-7
pubmed: 26770
Toxicol Sci. 2012 Jun;127(2):438-50
pubmed: 22491424
J Toxicol Environ Health A. 2000 Aug 25;60(8):531-48
pubmed: 10983521
Toxicol Appl Pharmacol. 2010 Jan 15;242(2):182-90
pubmed: 19835899
Semin Liver Dis. 2009 May;29(2):178-87
pubmed: 19387917
Clin Gastroenterol Hepatol. 2018 Jun;16(6):936-946
pubmed: 29199145
J Pharmacol Exp Ther. 2007 Sep;322(3):1208-20
pubmed: 17556636
Toxicol Sci. 2007 Nov;100(1):259-66
pubmed: 17709330
Gastroenterology. 2006 Jul;131(1):165-78
pubmed: 16831600
Hepatology. 2015 Aug;62(2):546-57
pubmed: 25712247
Gastroenterology. 2012 Nov;143(5):1158-1172
pubmed: 22982943
Toxicol Sci. 2006 Nov;94(1):217-25
pubmed: 16896059
Proc Natl Acad Sci U S A. 1971 Jan;68(1):160-4
pubmed: 4395686
Am J Gastroenterol. 2018 Sep;113(9):1319
pubmed: 29946176
Gastroenterology. 2006 Mar;130(3):687-94
pubmed: 16530510
Semin Liver Dis. 2008 May;28(2):142-52
pubmed: 18452114
Curr Drug Saf. 2007 Sep;2(3):177-85
pubmed: 18690965
Pharmacogenetics. 2000 Jun;10(4):355-69
pubmed: 10862526
J Am Pharm Assoc Am Pharm Assoc. 1958 Jul;47(7):479-87
pubmed: 13563249
Hepatology. 2006 Jun;43(6):1220-30
pubmed: 16729305
Chem Res Toxicol. 2012 Sep 17;25(9):1955-63
pubmed: 22867114
Gastroenterology. 2016 Apr;150(4):968-81
pubmed: 26708719
Am J Pathol. 1995 May;146(5):1220-34
pubmed: 7538266
Liver Int. 2010 Oct;30(9):1280-92
pubmed: 20500806
Biochem Pharmacol. 1974 Jan 15;23(2):295-302
pubmed: 4813346
Toxicol Sci. 2013 Jan;131(1):325-35
pubmed: 22986947
Toxicol Appl Pharmacol. 2013 Dec 15;273(3):484-91
pubmed: 24070586
Toxicol Appl Pharmacol. 2015 Jul 1;286(1):1-9
pubmed: 25818599
Toxicol Appl Pharmacol. 2014 Mar 1;275(2):122-33
pubmed: 24440789
Hepatology. 2013 Dec;58(6):2099-108
pubmed: 23744808
Crit Rev Toxicol. 2005 Apr-May;35(4):325-61
pubmed: 15989140
Xenobiotica. 2007 Dec;37(12):1367-77
pubmed: 17943662
Toxicol Appl Pharmacol. 2014 Feb 1;274(3):417-24
pubmed: 24345528
Toxicol Sci. 2002 Jun;67(2):322-8
pubmed: 12011492
J Hepatol. 2016 Aug;65(2):354-62
pubmed: 27151180
Biochem Pharmacol. 1997 Jul 1;54(1):73-80
pubmed: 9296352
Hepatology. 2004 Nov;40(5):1170-9
pubmed: 15486922
J Pharmacol Exp Ther. 2002 Feb;300(2):460-7
pubmed: 11805205
Toxicol Sci. 2012 Jan;125(1):126-33
pubmed: 21984482
J Pharmacol Exp Ther. 2010 May;333(2):364-72
pubmed: 20124411
Curr Opin Drug Discov Devel. 2001 Jan;4(1):55-9
pubmed: 11727323
Hepatology. 2012 Aug;56(2):735-46
pubmed: 22334567
Biomark Med. 2014;8(2):147-59
pubmed: 24521011
Liver Int. 2008 May;28(5):713-6
pubmed: 18433398
Toxicol Appl Pharmacol. 2008 May 1;228(3):295-300
pubmed: 18374380
Inflamm Bowel Dis. 2007 Mar;13(3):269-77
pubmed: 17206721
Gene Expr. 2017 Jul 7;17(3):187-205
pubmed: 28234577
Food Chem Toxicol. 2016 Dec;98(Pt B):107-118
pubmed: 27773698
Drug Metab Rev. 2012 Feb;44(1):34-87
pubmed: 21892896
Hepatology. 1991 May;13(5):815-9
pubmed: 2029987
J Toxicol Environ Health A. 2010;73(1):58-73
pubmed: 19953420
Cell Death Dis. 2014 Jun 05;5:e1278
pubmed: 24901049
Toxicol Sci. 2001 Aug;62(2):212-20
pubmed: 11452133
Pharmacology. 1974;12(3):129-43
pubmed: 4445191
Life Sci. 2006 Mar 6;78(15):1670-6
pubmed: 16226279
N Engl J Med. 1957 Jan 3;256(1):1-7
pubmed: 13388017
J Vet Pharmacol Ther. 2004 Jun;27(3):129-38
pubmed: 15189298
Toxicol Sci. 2009 Jul;110(1):235-43
pubmed: 19420014
PLoS One. 2013 Jul 18;8(7):e69114
pubmed: 23874883
J Pharmacol Exp Ther. 2005 Nov;315(2):879-87
pubmed: 16081675
Toxics. 2018 Apr 27;6(2):
pubmed: 29702608
J Pharmacol Exp Ther. 2008 Jan;324(1):8-14
pubmed: 17906064