Anterior nucleus of paraventricular thalamus mediates chronic mechanical hyperalgesia.
Amygdala
/ metabolism
Animals
Behavior, Animal
/ physiology
Chronic Pain
/ metabolism
Hyperalgesia
/ metabolism
Mice
Midline Thalamic Nuclei
/ metabolism
Neural Pathways
/ metabolism
Neurons
/ metabolism
Phosphorylation
Physical Stimulation
Proto-Oncogene Proteins c-fos
/ metabolism
Signal Transduction
/ physiology
Journal
Pain
ISSN: 1872-6623
Titre abrégé: Pain
Pays: United States
ID NLM: 7508686
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
entrez:
23
4
2019
pubmed:
23
4
2019
medline:
13
2
2020
Statut:
ppublish
Résumé
Pain-related diseases are the top leading causes of life disability. Identifying brain regions involved in persistent neuronal changes will provide new insights for developing efficient chronic pain treatment. Here, we showed that anterior nucleus of paraventricular thalamus (PVA) plays an essential role in the development of mechanical hyperalgesia in neuropathic and inflammatory pain models in mice. Increase in c-Fos, phosphorylated extracellular signal-regulated kinase, and hyperexcitability of PVA neurons were detected in hyperalgesic mice. Direct activation of PVA neurons using optogenetics and pharmacological approaches were sufficient to induce persistent mechanical hyperalgesia in naive animals. Conversely, inhibition of PVA neuronal activity using DREADDs (designer receptors exclusively activated by designer drugs) or inactivation of PVA extracellular signal-regulated kinase at the critical time window blunted mechanical hyperalgesia in chronic pain models. At the circuitry level, PVA received innervation from central nucleus of amygdala, a known pain-associated locus. As a result, activation of right central nucleus of amygdala with blue light was enough to induce persistent mechanical hyperalgesia. These findings support the idea that targeting PVA can be a potential therapeutic strategy for pain relief.
Identifiants
pubmed: 31009420
doi: 10.1097/j.pain.0000000000001497
pii: 00006396-201905000-00022
doi:
Substances chimiques
Proto-Oncogene Proteins c-fos
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1208-1223Références
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