Cardiovascular disease risk factor burden and cognition: Implications of ethnic diversity within the Hispanic Community Health Study/Study of Latinos.
Aged
Cardiovascular Diseases
/ epidemiology
Cognition
/ physiology
Cohort Studies
Cultural Diversity
Diabetes Mellitus
/ epidemiology
Female
Hispanic or Latino
/ statistics & numerical data
Humans
Hypercholesterolemia
/ epidemiology
Hypertension
/ epidemiology
Linear Models
Male
Middle Aged
Obesity
/ epidemiology
Prevalence
Public Health
/ statistics & numerical data
Risk Factors
United States
/ epidemiology
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
12
11
2018
accepted:
01
04
2019
entrez:
23
4
2019
pubmed:
23
4
2019
medline:
14
1
2020
Statut:
epublish
Résumé
Hispanics/Latinos have some of the highest prevalence rates for cardiovascular disease risk factors, but stark differences exist by self-reported background. Cardiovascular disease risk factors negatively impact cognition in Hispanics/Latinos; less is known about these relationships by Hispanic/Latino backgrounds. We investigated cognitive associations with cardiovascular disease risk factor burden in a diverse cohort, the Hispanic Community Health Study/Study of Latinos. Baseline data from this observational study of cardiovascular disease and its antecedents was collected from 2008-2011. We included 7,121 participants 45-74 years old from Central American, Cuban, Dominican, Mexican, Puerto Rican, or South American backgrounds. Dichotomous indicators for hypertension, diabetes, hypercholesterolemia, obesity, and smoking were evaluated and totaled, with participants grouped by lowest (0-2), middle (3) or highest (4-5) burden. Cognitive testing included the Brief Spanish English Verbal Learning Test, letter fluency, and digit symbol substitution. In separate fully-adjusted linear regression models, lower fluency and digit symbol substitution performance were restricted to the highest compared to the lowest burden group; whereas the middle burden group displayed impaired memory performance compared to the lowest burden group (p-values≤0.05). Background interacted with burden for learning and memory performance. That is, the association of burden level (i.e., lowest, middle, or highest) with cognitive performance was modified by background (e.g., Mexicans vs Cuban). Hispanics/Latinos with higher levels of cardiovascular disease risk factor burden displayed lower levels of cognitive performance, with learning and memory performance modified by background.
Identifiants
pubmed: 31009492
doi: 10.1371/journal.pone.0215378
pii: PONE-D-18-32503
pmc: PMC6476505
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0215378Subventions
Organisme : NHLBI NIH HHS
ID : N01 HC065234
Pays : United States
Organisme : NIA NIH HHS
ID : K01 AG040192
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01 HC065237
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK111022
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01 HC065236
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01 HC065235
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC65233
Pays : United States
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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