Detecting Early Pancreatic Cancer: Current Problems and Future Prospects.


Journal

Gut and liver
ISSN: 2005-1212
Titre abrégé: Gut Liver
Pays: Korea (South)
ID NLM: 101316452

Informations de publication

Date de publication:
15 01 2020
Historique:
received: 05 11 2018
revised: 05 01 2019
accepted: 25 01 2019
pubmed: 23 4 2019
medline: 5 11 2020
entrez: 23 4 2019
Statut: ppublish

Résumé

The number of patients with pancreatic cancer (PC) is currently increasing in both Korea and Japan. The 5-year survival rate of patients with PC 13.0%; however, resection with minimal invasion (tumor size: ≤10 mm) increases the 5-year survival rate to 80%. For this reason, early detection is essential, but most patients with early-stage PC are asymptomatic. Early detection of PC has been reported to require screening of high-risk individuals (HRIs), such as those with a family history of PC, inherited cancer syndromes, intraductal papillary mucinous neoplasm, or chronic pancreatitis. Studies on screening of these HRIs have confirmed a significantly better prognosis among patients with PC who were screened than for patients with PC who were not screened. However, to date in Japan, most patients with early-stage PC diagnosed in routine clinics were not diagnosed during annual health checks or by surveillance; rather, PC was detected in these patients by incidental findings during examinations for other diseases. We need to increase the precision of the PC screening and diagnostic processes by introducing new technologies, and we need to pay greater attention to incidental clinical findings.

Identifiants

pubmed: 31009958
pii: gnl18491
doi: 10.5009/gnl18491
pmc: PMC6974337
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

30-36

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Auteurs

Hiroyuki Matsubayashi (H)

Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.
Division of Genetic Medicine Promotion, Shizuoka Cancer Center, Shizuoka, Japan.

Hirotoshi Ishiwatari (H)

Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.

Keiko Sasaki (K)

Division of Pathology, Shizuoka Cancer Center, Shizuoka, Japan.

Katsuhiko Uesaka (K)

Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.

Hiroyuki Ono (H)

Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.

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