Synthesis of an Undecasaccharide Featuring an Oligomannosidic Heptasaccharide and a Bacterial Kdo-lipid A Backbone for Eliciting Neutralizing Antibodies to Mammalian Oligomannose on the HIV-1 Envelope Spike.
Journal
Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056
Informations de publication
Date de publication:
15 05 2019
15 05 2019
Historique:
pubmed:
24
4
2019
medline:
21
8
2020
entrez:
24
4
2019
Statut:
ppublish
Résumé
Lipooligosaccharides (LOS) from the bacterium Rhizobium radiobacter Rv3 are structurally related to antigenic mammalian oligomannoses on the HIV-1 envelope glycoprotein spike that are targets for broadly neutralizing antibodies. Here, we prepared a hybrid structure of viral and bacterial epitopes as part of a vaccine design strategy to elicit oligomannose-specific HIV-neutralizing antibodies using glycoconjugates based on the Rv3 LOS structure. Starting from a Kdo
Identifiants
pubmed: 31010286
doi: 10.1021/jacs.9b02872
pmc: PMC6524000
doi:
Substances chimiques
Antibodies, Neutralizing
0
Glycoconjugates
0
Lipid A
0
Oligosaccharides
0
env Gene Products, Human Immunodeficiency Virus
0
oligomannoside
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7946-7954Subventions
Organisme : NIGMS NIH HHS
ID : P41 GM103311
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI134299
Pays : United States
Organisme : CIHR
ID : IBC-150408
Pays : Canada
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