Auto-Abs neutralizing type I IFNs in patients with severe Powassan, Usutu, or Ross River virus disease.

Humans Interferon Type I / immunology Ross River virus / immunology Encephalitis, Tick-Borne / immunology Antibodies, Neutralizing / immunology Male Female Encephalitis Viruses, Tick-Borne / immunology Autoantibodies / immunology Alphavirus Infections / immunology Middle Aged Adult Aged Ross River Virus Infection Flavivirus

Journal

The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R

Informations de publication

Date de publication:
02 Dec 2024
Historique:
received: 31 05 2024
revised: 11 09 2024
accepted: 27 09 2024
medline: 1 11 2024
pubmed: 1 11 2024
entrez: 1 11 2024
Statut: ppublish

Résumé

Arboviral diseases are a growing global health concern. Pre-existing autoantibodies (auto-Abs) neutralizing type I interferons (IFNs) can underlie encephalitis due to West Nile virus (WNV) (∼40% of patients) and tick-borne encephalitis (TBE, due to TBE virus [TBEV]) (∼10%). We report here that these auto-Abs can also underlie severe forms of rarer arboviral infections. Auto-Abs neutralizing high concentrations of IFN-α2, IFN-β, and/or IFN-ω are present in the single case of severe Powassan virus (POWV) encephalitis studied, two of three cases of severe Usutu virus (USUV) infection studied, and the most severe of 24 cases of Ross River virus (RRV) disease studied. These auto-Abs are not found in any of the 137 individuals with silent or mild infections with these three viruses. Thus, auto-Abs neutralizing type I IFNs underlie an increasing list of severe arboviral diseases due to Flaviviridae (WNV, TBEV, POWV, USUV) or Togaviridae (RRV) viruses transmitted to humans by mosquitos (WNV, USUV, RRV) or ticks (TBEV, POWV).

Identifiants

DOI: 10.1084/jem.20240942 PMID: 39485284
pubmed: 39485284
pii: 277055
doi: 10.1084/jem.20240942
pii:
doi:

Substances chimiques

Interferon Type I 0
Antibodies, Neutralizing 0
Autoantibodies 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : Rockefeller University
Organisme : St. Giles Foundation
Organisme : Stavros Niarchos Foundation
Organisme : NIH HHS
ID : R01AI163029
Pays : United States
Organisme : NCATS NIH HHS
Pays : United States
Organisme : Fisher Center for Alzheimer's Research Foundation
Organisme : Meyer Foundation
Organisme : JPB Foundation
Organisme : Agence Nationale de la Recherche
ID : ANR-10-IAHU-01
Organisme : French Foundation for Medical Research
ID : EQU201903007798
Organisme : Square Foundation
Organisme : Grandir - Fonds de solidarité pour l'enfance
Organisme : Fondation du Souffle
Organisme : SCOR Corporate Foundation for Science
Organisme : French Ministry of Higher Education, Research, and Innovation
Organisme : Institut National de la Santé et de la Recherche Médicale
Organisme : Paris Cité University
Organisme : Imagine Institute
Organisme : Bettencourt-Schueller Foundation
Organisme : Fondazione IRCCS Policlinico San Matteo
Organisme : Italian Ministry of Health
ID : RC08061819
Organisme : National Health and Medical Research Council
ID : 1176665
Organisme : Battersea & Bowery Advisory Group
Organisme : San Matteo Hospital
ID : 08061821
Organisme : National Health and Medical Research Council of Australia
ID : 1176665
Organisme : ANRS-MIE
ID : ANRS0348

Informations de copyright

© 2024 Gervais et al.

Auteurs

Adrian Gervais (A)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, Paris Cité University , Paris, France.
ORCID: 0000-0002-1083-5787

Paul Bastard (P)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, Paris Cité University , Paris, France.
St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.
Pediatric Hematology-Immunology and Rheumatology Unit, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
ORCID: 0000-0002-5926-8437

Lucy Bizien (L)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, Paris Cité University , Paris, France.
ORCID: 0000-0001-9163-9122

Céline Delifer (C)

Établissement Français du Sang , La Plaine Saint-Denis, France.
ORCID: 0009-0000-6001-8921

Pierre Tiberghien (P)

Établissement Français du Sang , La Plaine Saint-Denis, France.
ORCID: 0000-0002-9310-8322

Chaturaka Rodrigo (C)

Faculty of Medicine, School of Biomedical Sciences, UNSW Australia, Sydney, Australia.
ORCID: 0000-0003-2189-9177

Francesca Trespidi (F)

Neonatal Intensive Care Unit, San Matteo Research Hospital, Pavia, Italy.
ORCID: 0009-0007-7206-6796

Micol Angelini (M)

Neonatal Intensive Care Unit, San Matteo Research Hospital, Pavia, Italy.
ORCID: 0000-0001-7255-4115

Giada Rossini (G)

Microbiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna , Bologna, Italy.
ORCID: 0000-0002-8917-6680

Tiziana Lazzarotto (T)

Microbiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna , Bologna, Italy.
Department of Medical and Surgical Sciences, Section of Microbiology, University of Bologna, Bologna, Italy.
ORCID: 0000-0003-3093-363X

Francesca Conti (F)

Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna , Bologna, Italy.
Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
ORCID: 0000-0002-3665-8926

Irene Cassaniti (I)

Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
ORCID: 0000-0002-3385-2088

Fausto Baldanti (F)

Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
ORCID: 0000-0002-3358-8969

Francesca Rovida (F)

Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
ORCID: 0000-0003-2345-2790

Alessandro Ferrari (A)

Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
ORCID: 0000-0003-2397-7079

Davide Mileto (D)

Laboratory of Clinical Microbiology, Virology and Bioemergencies, Luigi Sacco Hospital, ASST Fatebenefratelli Sacco, Milan, Italy.
ORCID: 0000-0002-9414-0287

Alessandro Mancon (A)

Laboratory of Clinical Microbiology, Virology and Bioemergencies, Luigi Sacco Hospital, ASST Fatebenefratelli Sacco, Milan, Italy.
ORCID: 0000-0002-1490-636X

Laurent Abel (L)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, Paris Cité University , Paris, France.
St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.
ORCID: 0000-0001-7016-6493

Anne Puel (A)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, Paris Cité University , Paris, France.
St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.
ORCID: 0000-0003-2603-0323

Aurélie Cobat (A)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, Paris Cité University , Paris, France.
St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.
ORCID: 0000-0001-7209-6257

Charles M Rice (CM)

Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.
ORCID: 0000-0003-3087-8079

Dániel Cadar (D)

Bernhard Nocht Institute for Tropical Medicine , Hamburg, Germany.
ORCID: 0000-0002-8063-2766

Jonas Schmidt-Chanasit (J)

Bernhard Nocht Institute for Tropical Medicine , Hamburg, Germany.
Faculty of Mathematics, Informatics and Natural Sciences, University of Hamburg, Hamburg, Germany.
ORCID: 0000-0003-4433-0231

Johannes F Scheid (JF)

Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA.
ORCID: 0009-0002-1140-1611

Jacob E Lemieux (JE)

Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA.
ORCID: 0000-0002-2758-4005

Eric S Rosenberg (ES)

Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA.
ORCID: 0009-0002-3650-7375

Marianna Agudelo (M)

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.
ORCID: 0000-0003-3924-6449

Stuart G Tangye (SG)

Garvan Institute of Medical Research , Darlinghurst, Australia.
Faculty of Medicine and Health, School of Clinical Medicine, University of New South Wales Sydney, Sydney, Australia.
ORCID: 0000-0002-5360-5180

Alessandro Borghesi (A)

Neonatal Intensive Care Unit, San Matteo Research Hospital, Pavia, Italy.
School of Life Sciences, Swiss Federal Institute of Technology , Lausanne, Switzerland.
ORCID: 0000-0002-8773-9144

Guillaume André Durand (GA)

National Reference Center for Arboviruses, Inserm-IRBA , Marseille, France.
Unité des Virus Émergents (UVE: Aix-Marseille Univ-Corsica Univ-IRD 190-Inserm 1207-IRBA) , Marseille, France.
ORCID: 0000-0003-3348-9618

Emilie Duburcq-Gury (E)

Intensive Care Unit, Saint Philibert Hospital, Lille Catholic Hospitals, Lille, France.
ORCID: 0000-0002-6935-0354

Braulio M Valencia (BM)

The Kirby Institute, UNSW Australia , Sydney, Australia.
ORCID: 0000-0001-6741-3908

Andrew R Lloyd (AR)

The Kirby Institute, UNSW Australia , Sydney, Australia.
ORCID: 0000-0001-6277-8887

Anna Nagy (A)

National Reference Laboratory for Viral Zoonoses, National Public Health Center, Budapest, Hungary.
ORCID: 0000-0002-4081-2308

Margaret M MacDonald (MM)

Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.
ORCID: 0000-0001-5177-2068

Yannick Simonin (Y)

Pathogenesis and Control of Chronic and Emerging Infections, University of Montpellier, INSERM, EFS , Montpellier, France.
ORCID: 0000-0002-3475-1369

Shen-Ying Zhang (SY)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, Paris Cité University , Paris, France.
St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.
ORCID: 0000-0002-9449-3672

Jean-Laurent Casanova (JL)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, Paris Cité University , Paris, France.
St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA.
Howard Hughes Medical Institute , New York, NY, USA.
Department of Pediatrics, Necker Hospital for Sick Children, AP-HP, Paris, France.
ORCID: 0000-0002-7782-4169

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Auto-Abs neutralizing type I IFNs in patients...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interférons › Interféron de type I › Auto-Abs neutralizing type I IFNs in patients...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Togaviridae › Alphavirus › Virus de la rivière Ross › Auto-Abs neutralizing type I IFNs in patients...
questionsmedicales.fr › Maladies du système nerveux › Encéphalite › Encéphalite infectieuse › Encéphalite virale › Encéphalite à arbovirus › Encéphalites à tiques › Auto-Abs neutralizing type I IFNs in patients...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps neutralisants › Auto-Abs neutralizing type I IFNs in patients...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Flaviviridae › Flavivirus › Virus de l'encéphalite à tiques (sous-groupe) › Auto-Abs neutralizing type I IFNs in patients...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Autoanticorps › Auto-Abs neutralizing type I IFNs in patients...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Togaviridae › Infections à alphavirus › Auto-Abs neutralizing type I IFNs in patients...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Auto-Abs neutralizing type I IFNs in patients...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Auto-Abs neutralizing type I IFNs in patients...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Auto-Abs neutralizing type I IFNs in patients...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Flaviviridae › Flavivirus › Auto-Abs neutralizing type I IFNs in patients...