Chronic functional constipation is strongly linked to vitamin D deficiency.
Adult
Aged
Anxiety
/ epidemiology
Case-Control Studies
Chronic Disease
/ epidemiology
Constipation
/ epidemiology
Depression
/ epidemiology
Female
Gastrointestinal Diseases
/ epidemiology
Gastrointestinal Transit
/ physiology
Healthy Volunteers
Humans
Male
Middle Aged
Prevalence
Prospective Studies
Quality of Life
Vitamin D
/ analogs & derivatives
Vitamin D Deficiency
/ blood
Anxiety
Chronic constipation
Depression
Intestinal motility
Quality of life
Vitamin D
Journal
World journal of gastroenterology
ISSN: 2219-2840
Titre abrégé: World J Gastroenterol
Pays: United States
ID NLM: 100883448
Informations de publication
Date de publication:
14 Apr 2019
14 Apr 2019
Historique:
received:
16
02
2019
revised:
11
03
2019
accepted:
24
03
2019
entrez:
24
4
2019
pubmed:
24
4
2019
medline:
27
8
2019
Statut:
ppublish
Résumé
Few studies have examined intestinal motility disorders, which are disabling conditions associated with chronic functional constipation, whose pathogenesis is actually not well-defined. To investigate the relationship between serum 25-hydroxyvitamin D levels and functional chronic constipation associated to intestinal motility disorders. We performed a prospective case-control study, from May-June to November 2017. Glucose/lactulose breath tests, radiopaque markers (multiple capsule techniques) and wireless motility capsule analysis were used to assess colonic and oro-cecal transit time, after excluding small-intestinal bacterial overgrowth condition. Then, we measured 25-hydroxyvitamin D levels in patients with intestinal motility disorders and we further evaluated the influence of intestinal motility disorders on psychological symptoms/quality of life using validated questionnaires, the Irritable Bowel Syndrome Quality of life (IBS-QOL), the Short Form Health Survey 12, and the Hospital Anxiety and Depression Scale 14 (HADS-14 A and HADS-14 D). We enrolled 86 patients with chronic functional constipation associated to intestinal motility disorders and 86 matched healthy subjects. Patients with intestinal motility disorders had lower 25-hydroxyvitamin D levels ( Vitamin D deficiency, anxiety and depression symptoms are commonly associated with chronic functional constipation induced by intestinal motility disorders. Vitamin D serum levels should be routinely measured in these patients.
Sections du résumé
BACKGROUND
BACKGROUND
Few studies have examined intestinal motility disorders, which are disabling conditions associated with chronic functional constipation, whose pathogenesis is actually not well-defined.
AIM
OBJECTIVE
To investigate the relationship between serum 25-hydroxyvitamin D levels and functional chronic constipation associated to intestinal motility disorders.
METHODS
METHODS
We performed a prospective case-control study, from May-June to November 2017. Glucose/lactulose breath tests, radiopaque markers (multiple capsule techniques) and wireless motility capsule analysis were used to assess colonic and oro-cecal transit time, after excluding small-intestinal bacterial overgrowth condition. Then, we measured 25-hydroxyvitamin D levels in patients with intestinal motility disorders and we further evaluated the influence of intestinal motility disorders on psychological symptoms/quality of life using validated questionnaires, the Irritable Bowel Syndrome Quality of life (IBS-QOL), the Short Form Health Survey 12, and the Hospital Anxiety and Depression Scale 14 (HADS-14 A and HADS-14 D).
RESULTS
RESULTS
We enrolled 86 patients with chronic functional constipation associated to intestinal motility disorders and 86 matched healthy subjects. Patients with intestinal motility disorders had lower 25-hydroxyvitamin D levels (
CONCLUSION
CONCLUSIONS
Vitamin D deficiency, anxiety and depression symptoms are commonly associated with chronic functional constipation induced by intestinal motility disorders. Vitamin D serum levels should be routinely measured in these patients.
Identifiants
pubmed: 31011257
doi: 10.3748/wjg.v25.i14.1729
pmc: PMC6465937
doi:
Substances chimiques
Vitamin D
1406-16-2
25-hydroxyvitamin D
A288AR3C9H
Types de publication
Journal Article
Langues
eng
Pagination
1729-1740Déclaration de conflit d'intérêts
Conflict-of-interest statement: All authors declare no conflict of interest related to this publication.
Références
Am J Gastroenterol. 2000 Apr;95(4):999-1007
pubmed: 10763950
Am J Gastroenterol. 2001 Nov;96(11):3130-7
pubmed: 11721760
Osteoporos Int. 2001 Dec;12(12):1026-30
pubmed: 11846328
Gastroenterology. 2003 Jul;125(1):70-9
pubmed: 12851872
Neurogastroenterol Motil. 2004 Oct;16(5):515-31
pubmed: 15500508
Lancet. 2006 May 27;367(9524):1747-57
pubmed: 16731270
Br J Clin Psychol. 2007 Mar;46(Pt 1):1-18
pubmed: 17472198
Aliment Pharmacol Ther. 2007 Jul 15;26(2):227-36
pubmed: 17593068
N Engl J Med. 2007 Jul 19;357(3):266-81
pubmed: 17634462
Clin Gastroenterol Hepatol. 2009 May;7(5):537-44
pubmed: 19418602
Bone. 2009 Sep;45(3):423-6
pubmed: 19465168
Aliment Pharmacol Ther. 2010 May;31(9):938-49
pubmed: 20180788
Nat Rev Drug Discov. 2010 Dec;9(12):941-55
pubmed: 21119732
Neurogastroenterol Motil. 2011 Jan;23(1):8-23
pubmed: 21138500
Neurogastroenterol Motil. 2011 Aug;23(8):697-710
pubmed: 21605282
Am J Gastroenterol. 2011 Sep;106(9):1582-91; quiz 1581, 1592
pubmed: 21606976
J Neurogastroenterol Motil. 2011 Jul;17(3):312-7
pubmed: 21860825
Am J Gastroenterol. 2012 Feb;107(2):286-95
pubmed: 22068664
Br J Psychiatry. 2013 Feb;202:100-7
pubmed: 23377209
Gastroenterology. 2013 Oct;145(4):749-57; quiz e13-4
pubmed: 23872499
J Clin Endocrinol Metab. 2014 Mar;99(3):757-67
pubmed: 24423304
Am J Gastroenterol. 2014 Sep;109(9):1450-60
pubmed: 24980882
United European Gastroenterol J. 2014 Jun;2(3):232-8
pubmed: 25360307
Gastroenterology. 2016 Feb;150(2):367-79.e1
pubmed: 26460205
BMJ Open Gastroenterol. 2015 Dec 21;2(1):e000052
pubmed: 26719813
Am J Clin Nutr. 2016 Apr;103(4):1033-44
pubmed: 26864360
Nat Rev Gastroenterol Hepatol. 2016 May;13(5):295-305
pubmed: 27033126
Gastroenterology. 2016 Feb 18;:null
pubmed: 27144627
Neurogastroenterol Motil. 2016 Oct;28(10):1533-44
pubmed: 27154424
J Steroid Biochem Mol Biol. 2017 Oct;173:228-234
pubmed: 27777183
Sci Rep. 2016 Dec 01;6:38216
pubmed: 27905561
Front Immunol. 2016 Dec 23;7:627
pubmed: 28066436
Am J Gastroenterol. 2017 May;112(5):775-784
pubmed: 28323273
Sci Rep. 2017 Mar 27;7(1):441
pubmed: 28348415
Lancet Diabetes Endocrinol. 2017 Dec;5(12):986-1004
pubmed: 29102433
Neurogastroenterol Motil. 2017 Dec;29(12):null
pubmed: 29143474
Endocrinology. 2018 Feb 1;159(2):967-979
pubmed: 29228157
Lancet. 2018 Apr 21;391(10130):1622-1636
pubmed: 29576504
Neurogastroenterol Motil. 2018 Sep;30(9):e13349
pubmed: 29644797
Gastroenterology. 1987 Jan;92(1):40-7
pubmed: 3023168
Aliment Pharmacol Ther. 2018 Nov;48(10):1138-1145
pubmed: 30375693
Gastroenterol Clin Biol. 1986 May;10(5):385-9
pubmed: 3732742
Lancet. 1980 Feb 9;1(8163):316
pubmed: 6101773
Lancet. 1995 Jul 22;346(8969):207-10
pubmed: 7616799
J Neurol Neurosurg Psychiatry. 1996 Jan;60(1):31-5
pubmed: 8558147
J Clin Epidemiol. 1998 Nov;51(11):1171-8
pubmed: 9817135