Push-Pull Stilbene: Visible Light Activated Photoremovable Protecting Group for Alcohols and Carboxylic Acids with Fluorescence Reporting Employed for Drug Delivery.
Alcohols
/ chemistry
Antineoplastic Agents
/ administration & dosage
Carboxylic Acids
/ chemistry
Cell Survival
/ drug effects
Chlorambucil
/ administration & dosage
Cyclization
Drug Carriers
Drug Liberation
Fluorescent Dyes
/ chemistry
Humans
Light
MCF-7 Cells
Optical Imaging
/ methods
Photolysis
Spectrometry, Fluorescence
/ methods
Stilbenes
/ chemistry
Journal
Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393
Informations de publication
Date de publication:
03 05 2019
03 05 2019
Historique:
pubmed:
24
4
2019
medline:
31
7
2019
entrez:
24
4
2019
Statut:
ppublish
Résumé
For the first time we have utilized push-pull stilbene as a visible light activated photoremovable protecting group (PRPG) for the uncaging of alcohols and carboxylic acids. The PRPG efficiently release caged molecules with good photochemical quantum yield. It is capable of monitoring the release in real time owing to its fluorescence "turn on" phenomenon upon photorelease in polar medium. The efficient photorelease and real time monitoring abilities of push-pull stilbene were employed for in vitro drug delivery.
Identifiants
pubmed: 31013105
doi: 10.1021/acs.orglett.9b00124
doi:
Substances chimiques
Alcohols
0
Antineoplastic Agents
0
Carboxylic Acids
0
Drug Carriers
0
Fluorescent Dyes
0
Stilbenes
0
Chlorambucil
18D0SL7309
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng