Association between Interleukin 35 Gene Single Nucleotide Polymorphisms and Systemic Lupus Erythematosus in a Chinese Han Population.
autoimmune diseases
gene single nucleotide polymorphisms
interleukin-35
systemic lupus erythematosus
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
22 04 2019
22 04 2019
Historique:
received:
01
03
2019
revised:
13
04
2019
accepted:
19
04
2019
entrez:
25
4
2019
pubmed:
25
4
2019
medline:
10
1
2020
Statut:
epublish
Résumé
Interleukin-35 (IL-35) exerts crucial roles in the pathogenesis and development of systemic lupus erythematosus (SLE), in this study we aim to explore the associations between IL-35 gene polymorphisms and the susceptibility, clinical features and plasma IL-35 levels of SLE patients, respectively. 490 SLE patients and 489 healthy controls were recruited in our study. The correlations between the polymorphisms of seven SNPs of IL-35 encoding gene and the susceptibility, main clinical manifestations of SLE were evaluated, respectively. Plasma IL-35 levels were assessed in 76 SLE patients, and the associations between plasma IL-35 levels and the polymorphisms of genotyped SNPs were explored. There were significant associations between the polymorphisms of rs4740 and the occurrence of renal disorder, hematological disorder in SLE patients, respectively (
Identifiants
pubmed: 31013577
pii: biom9040157
doi: 10.3390/biom9040157
pmc: PMC6523873
pii:
doi:
Substances chimiques
EBI3 protein, human
0
Interleukins
0
Minor Histocompatibility Antigens
0
interleukin-35, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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