Expression of Longevity Genes Induced by a Low-Dose Fluvastatin and Valsartan Combination with the Potential to Prevent/Treat "Aging-Related Disorders".
AMP-Activated Protein Kinases
/ genetics
Adult
Aging
/ genetics
Angiotensin II Type 1 Receptor Blockers
/ pharmacology
Dose-Response Relationship, Drug
Female
Fluvastatin
/ pharmacology
Gene Expression
/ drug effects
Glucuronidase
/ genetics
Humans
Klotho Proteins
Longevity
/ genetics
Male
Middle Aged
Neurodegenerative Diseases
/ prevention & control
Placebo Effect
Sirtuin 1
/ genetics
Telomerase
/ metabolism
Valsartan
/ pharmacology
aging-related disorders
arterial aging
longevity genes
low-dose fluvastatin and valsartan combination
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 Apr 2019
14 Apr 2019
Historique:
received:
13
03
2019
revised:
10
04
2019
accepted:
12
04
2019
entrez:
25
4
2019
pubmed:
25
4
2019
medline:
9
8
2019
Statut:
epublish
Résumé
The incidence of aging-related disorders may be decreased through strategies influencing the expression of longevity genes. Although numerous approaches have been suggested, no effective, safe, and easily applicable approach is yet available. Efficacy of low-dose fluvastatin and valsartan, separately or in combination, on the expression of the longevity genes in middle-aged males, was assessed. Stored blood samples from 130 apparently healthy middle-aged males treated with fluvastatin (10 mg daily), valsartan (20 mg daily), fluvastatin-valsartan combination (10 and 20 mg, respectively), and placebo (control) were analyzed. They were taken before and after 30 days of treatment and, additionally, five months after treatment discontinuation. The expression of the following longevity genes was assessed:
Identifiants
pubmed: 31013989
pii: ijms20081844
doi: 10.3390/ijms20081844
pmc: PMC6514706
pii:
doi:
Substances chimiques
Angiotensin II Type 1 Receptor Blockers
0
Fluvastatin
4L066368AS
Valsartan
80M03YXJ7I
AMP-Activated Protein Kinases
EC 2.7.11.31
Telomerase
EC 2.7.7.49
Glucuronidase
EC 3.2.1.31
Klotho Proteins
EC 3.2.1.31
Sirtuin 1
EC 3.5.1.-
Types de publication
Clinical Trial
Journal Article
Langues
eng
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