STIM1 at the plasma membrane as a new target in progressive chronic lymphocytic leukemia.
Aged
Antibodies, Monoclonal
/ pharmacology
Antineoplastic Agents, Immunological
/ pharmacology
B-Lymphocytes
/ cytology
Calcium
/ immunology
Calcium Signaling
/ genetics
Cell Membrane
/ metabolism
Cell Survival
/ drug effects
Disease Progression
Female
Gene Knockdown Techniques
Humans
Leukemia, Lymphocytic, Chronic, B-Cell
/ blood
Male
Neoplasm Proteins
/ antagonists & inhibitors
ORAI1 Protein
/ antagonists & inhibitors
Primary Cell Culture
Prospective Studies
RNA, Small Interfering
/ metabolism
Stromal Interaction Molecule 1
/ antagonists & inhibitors
TRPC Cation Channels
/ genetics
Treatment Outcome
Tumor Cells, Cultured
CLL
Constitutive Ca2+ entry
Disease outcome
STIM1
Journal
Journal for immunotherapy of cancer
ISSN: 2051-1426
Titre abrégé: J Immunother Cancer
Pays: England
ID NLM: 101620585
Informations de publication
Date de publication:
23 04 2019
23 04 2019
Historique:
received:
30
01
2019
accepted:
02
04
2019
entrez:
25
4
2019
pubmed:
25
4
2019
medline:
8
7
2020
Statut:
epublish
Résumé
Dysregulation in calcium (Ca An extensive analysis of the Ca Seeking to explore the CE pathway, we found in untreated CLL patients that an abnormal CE pathway was (i) highly associated with the disease outcome; (ii) positively correlated with basal Ca These data establish the critical role of a newly discovered BCR independent Ca
Sections du résumé
BACKGROUND
Dysregulation in calcium (Ca
METHODS
An extensive analysis of the Ca
RESULTS
Seeking to explore the CE pathway, we found in untreated CLL patients that an abnormal CE pathway was (i) highly associated with the disease outcome; (ii) positively correlated with basal Ca
CONCLUSIONS
These data establish the critical role of a newly discovered BCR independent Ca
Identifiants
pubmed: 31014395
doi: 10.1186/s40425-019-0591-3
pii: 10.1186/s40425-019-0591-3
pmc: PMC6480884
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antineoplastic Agents, Immunological
0
Neoplasm Proteins
0
ORAI1 Protein
0
ORAI1 protein, human
0
RNA, Small Interfering
0
STIM1 protein, human
0
Stromal Interaction Molecule 1
0
TRPC Cation Channels
0
transient receptor potential cation channel, subfamily C, member 1
0
Calcium
SY7Q814VUP
Banques de données
ClinicalTrials.gov
['NCT03294980']
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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