Bacterial Genome-Wide Association Identifies Novel Factors That Contribute to Ethionamide and Prothionamide Susceptibility in Mycobacterium tuberculosis.

Antitubercular Agents / pharmacology China Drug Resistance, Bacterial Ethionamide / pharmacology Genome-Wide Association Study Microbial Sensitivity Tests Mutation Mycobacterium tuberculosis / drug effects Oxidoreductases / genetics Prothionamide / pharmacology
Mycobacterium tuberculosis antibiotic resistance ethionamide genome analysis genome-wide association study prothionamide

Journal

mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231

Informations de publication

Date de publication:
23 04 2019
Historique:
entrez: 25 4 2019
pubmed: 25 4 2019
medline: 21 6 2019
Statut: epublish

Résumé

In

Identifiants

DOI: 10.1128/mBio.00616-19 PMID: 31015328 PMC: PMC6479004
pubmed: 31015328
pii: mBio.00616-19
doi: 10.1128/mBio.00616-19
pmc: PMC6479004
pii:
doi:

Substances chimiques

Antitubercular Agents 0
Prothionamide 76YOO33643
Oxidoreductases EC 1.-
Ethionamide OAY8ORS3CQ

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIAID NIH HHS
ID : T32 AI007061
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI109755
Pays : United States

Informations de copyright

Copyright © 2019 Hicks et al.

Références

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Auteurs

Nathan D Hicks (ND)

Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.

Allison F Carey (AF)

Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Jian Yang (J)

MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, and Centre for Tuberculosis, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Yanlin Zhao (Y)

National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

Sarah M Fortune (SM)

Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA sfortune@hsph.harvard.edu.
Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA.
Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Antituberculeux › Bacterial Genome-Wide Association Identifies...
questionsmedicales.fr › Régions géographiques › Asie › Extrême-Orient › Chine › Bacterial Genome-Wide Association Identifies...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance bactérienne aux médicaments › Bacterial Genome-Wide Association Identifies...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Acides isonicotiniques › Éthionamide › Bacterial Genome-Wide Association Identifies...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Bacterial Genome-Wide Association Identifies...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Bacterial Genome-Wide Association Identifies...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Bacterial Genome-Wide Association Identifies...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis › Bacterial Genome-Wide Association Identifies...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Bacterial Genome-Wide Association Identifies...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Acides isonicotiniques › Protionamide › Bacterial Genome-Wide Association Identifies...