Spatial multiplex analysis of lung cancer reveals that regulatory T cells attenuate KRAS-G12C inhibitor-induced immune responses.
T-Lymphocytes, Regulatory
/ immunology
Lung Neoplasms
/ immunology
Proto-Oncogene Proteins p21(ras)
/ genetics
Animals
Humans
Tumor Microenvironment
/ immunology
Mice
CD8-Positive T-Lymphocytes
/ immunology
Cell Line, Tumor
Programmed Cell Death 1 Receptor
/ antagonists & inhibitors
Mutation
Immunotherapy
/ methods
Dendritic Cells
/ immunology
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
Nov 2024
Nov 2024
Historique:
medline:
2
11
2024
pubmed:
2
11
2024
entrez:
1
11
2024
Statut:
ppublish
Résumé
Kirsten rat sarcoma virus (KRAS)-G12C inhibition causes remodeling of the lung tumor immune microenvironment and synergistic responses to anti-PD-1 treatment, but only in T cell infiltrated tumors. To investigate mechanisms that restrain combination immunotherapy sensitivity in immune-excluded tumors, we used imaging mass cytometry to explore cellular distribution in an immune-evasive KRAS mutant lung cancer model. Cellular spatial pattern characterization revealed a community where CD4
Identifiants
pubmed: 39485838
doi: 10.1126/sciadv.adl6464
doi:
Substances chimiques
Proto-Oncogene Proteins p21(ras)
EC 3.6.5.2
Programmed Cell Death 1 Receptor
0
KRAS protein, human
0
Hras protein, mouse
EC 3.6.5.2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM