Lipoprotein modulation of proteinuric renal injury.
Animals
Apolipoprotein A-I
/ pharmacology
Cells, Cultured
Humans
Interleukin-2 Receptor alpha Subunit
/ metabolism
Kidney Diseases
/ metabolism
Kidney Glomerulus
/ drug effects
Lipoproteins, HDL
/ pharmacology
Mice
Mice, Transgenic
Podocytes
/ drug effects
Protective Agents
/ pharmacology
Proteinuria
/ metabolism
Puromycin Aminonucleoside
/ adverse effects
Journal
Laboratory investigation; a journal of technical methods and pathology
ISSN: 1530-0307
Titre abrégé: Lab Invest
Pays: United States
ID NLM: 0376617
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
08
11
2018
accepted:
04
03
2019
revised:
08
02
2019
pubmed:
26
4
2019
medline:
27
6
2020
entrez:
26
4
2019
Statut:
ppublish
Résumé
High-density lipoprotein (HDL) and its main protein, apolipoprotein AI (apoAI), have established benefits in various cells, but whether these cytoprotective effects of HDL pertain to renal cells is unclear. We investigated the in vitro consequences of exposing damaged podocytes to normal apoAI, HDL, and apoAI mimetic (L-4F), and the in vivo effects of L-4F on kidney and atherosclerotic injury in a podocyte-specific injury model of proteinuria. In vitro, primary mouse podocytes were injured by puromycin aminonucleoside (PAN). Cellular viability, migration, production of reactive oxygen species (ROS), apoptosis, and the underlying signaling pathway were assessed. In vivo, we used a proteinuric model, Nphs1-hCD25 transgenic (NEP25
Identifiants
pubmed: 31019291
doi: 10.1038/s41374-019-0253-6
pii: S0023-6837(22)00691-2
pmc: PMC6658349
mid: NIHMS1523230
doi:
Substances chimiques
Apolipoprotein A-I
0
IL2RA protein, human
0
Interleukin-2 Receptor alpha Subunit
0
Lipoproteins, HDL
0
Protective Agents
0
Puromycin Aminonucleoside
58-60-6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1107-1116Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM115367
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK056942
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL116263
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK108836
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK079626
Pays : United States
Références
Mol Cancer Ther. 2012 Jun;11(6):1311-9
pubmed: 22416044
Nutr Diabetes. 2014 Sep 01;4:e134
pubmed: 25177914
J Am Coll Cardiol. 2012 Aug 7;60(6):517-20
pubmed: 22796252
Anal Biochem. 2008 Aug 15;379(2):213-5
pubmed: 18503744
Biomed Pharmacother. 2018 Oct;106:117-124
pubmed: 29957461
Biochem Biophys Res Commun. 2012 Oct 12;427(1):24-9
pubmed: 22982675
Semin Nephrol. 2004 Sep;24(5):469-73
pubmed: 15490413
Microsc Microanal. 2008 Apr;14(2):138-49
pubmed: 18312718
Nat Rev Drug Discov. 2014 Jun;13(6):445-64
pubmed: 24854407
Curr Atheroscler Rep. 2010 Mar;12(2):96-104
pubmed: 20425244
Clin Chim Acta. 2012 Dec 24;414:241-5
pubmed: 23041214
Kidney Int. 2013 Sep;84(3):451-6
pubmed: 23698234
Kidney Int. 2016 Apr;89(4):809-22
pubmed: 26994575
Arch Med Sci. 2016 Aug 1;12(4):844-9
pubmed: 27478466
Curr Cardiol Rep. 2013 Mar;15(3):340
pubmed: 23338722
Kidney Blood Press Res. 2018;43(1):206-219
pubmed: 29490300
Circulation. 2008 Mar 25;117(12):1563-73
pubmed: 18332268
Kidney Int. 2007 Aug;72(4):489-98
pubmed: 17554257
J Am Soc Nephrol. 2011 Jul;22(7):1275-85
pubmed: 21719786
Eur Rev Med Pharmacol Sci. 2014 Oct;18(19):2918-26
pubmed: 25339487
Am J Physiol Regul Integr Comp Physiol. 2014 Sep 1;307(5):R514-24
pubmed: 24920733
Biochim Biophys Acta. 2012 Mar;1821(3):522-9
pubmed: 21920460
Am J Pathol. 2002 Sep;161(3):799-805
pubmed: 12213707
J Am Soc Nephrol. 2016 Feb;27(2):595-603
pubmed: 26319244
Circ J. 2011;75(7):1533-8
pubmed: 21628835
Atherosclerosis. 2006 Feb;184(2):312-21
pubmed: 16023123
J Am Soc Nephrol. 2005 May;16(5):1309-19
pubmed: 15788471
N Engl J Med. 2004 Sep 23;351(13):1296-305
pubmed: 15385656
Pediatr Nephrol. 2019 Oct;34(10):1683-1695
pubmed: 30291429
Front Physiol. 2017 Oct 30;8:841
pubmed: 29163190
J Lipid Res. 2011 Jun;52(6):1200-10
pubmed: 21444758
PLoS One. 2012;7(8):e40724
pubmed: 22899991
N Engl J Med. 2014 Dec 18;371(25):2383-93
pubmed: 25404125
J Endocrinol Invest. 2013 Sep;36(8):574-8
pubmed: 23404243
Circulation. 2002 Jan 22;105(3):290-2
pubmed: 11804981
Lipids. 2016 Mar;51(3):311-20
pubmed: 26781765
Kidney Int. 2018 Dec;94(6):1151-1159
pubmed: 30301568
J Am Coll Cardiol. 2012 Dec 11;60(23):2372-9
pubmed: 23141484
PLoS One. 2015 May 22;10(5):e0127507
pubmed: 26000608
Ann Intern Med. 2014 Feb 4;160(3):182
pubmed: 24323134
J Clin Invest. 2001 Jan;107(2):163-71
pubmed: 11160132
Eur Heart J. 2014 Dec 7;35(46):3277-86
pubmed: 24780501
Diabetes. 2013 Nov;62(11):3817-27
pubmed: 23835338
Circ Res. 2010 Jul 9;107(1):106-16
pubmed: 20448215
J Am Soc Nephrol. 2005 Apr;16(4):1013-23
pubmed: 15758046
Lipids. 2008 May;43(5):467-70
pubmed: 18350327
J Nephropathol. 2014 Jul;3(3):99-104
pubmed: 25093157
Front Physiol. 2017 Nov 01;8:869
pubmed: 29163211
Immunobiology. 2015 Aug;220(8):947-53
pubmed: 25720636
Nephrol Dial Transplant. 2013 Oct;28(10):2456-63
pubmed: 23645475
Adv Chronic Kidney Dis. 2011 Jul;18(4):258-66
pubmed: 21782132
J Biol Chem. 2013 Jul 19;288(29):21237-52
pubmed: 23720750
Kidney Int. 2016 Jan;89(1):58-67
pubmed: 26759048
Atherosclerosis. 2015 Aug;241(2):709-15
pubmed: 26125413
Circ Res. 2013 May 10;112(10):1345-54
pubmed: 23501697
J Clin Invest. 2016 Sep 1;126(9):3336-50
pubmed: 27482889
J Lipid Res. 2010 Sep;51(9):2695-705
pubmed: 20495214
Pediatr Res. 2011 Jul;70(1):83-9
pubmed: 21451433
Arterioscler Thromb Vasc Biol. 2005 Jul;25(7):1426-32
pubmed: 15845909
Curr Eye Res. 2018 Jan;43(1):135-146
pubmed: 28972410
World J Gastroenterol. 2015 Feb 14;21(6):1804-13
pubmed: 25684945