Structural basis of ligand recognition at the human MT
Acetamides
/ chemistry
Amino Acid Sequence
Antidepressive Agents
/ chemistry
Crystallization
Electrons
Humans
Indenes
/ chemistry
Lasers
Ligands
Melatonin
/ analogs & derivatives
Models, Molecular
Molecular Docking Simulation
Mutation
Receptor, Melatonin, MT1
/ agonists
Receptor, Serotonin, 5-HT2C
/ chemistry
Structure-Activity Relationship
Substrate Specificity
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
28
07
2018
accepted:
25
03
2019
pubmed:
26
4
2019
medline:
22
1
2020
entrez:
26
4
2019
Statut:
ppublish
Résumé
Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that maintains circadian rhythms
Identifiants
pubmed: 31019306
doi: 10.1038/s41586-019-1141-3
pii: 10.1038/s41586-019-1141-3
pmc: PMC6696938
mid: NIHMS1525418
doi:
Substances chimiques
Acetamides
0
Antidepressive Agents
0
Indenes
0
Ligands
0
Receptor, Melatonin, MT1
0
Receptor, Serotonin, 5-HT2C
0
agomelatine
137R1N49AD
ramelteon
901AS54I69
Melatonin
JL5DK93RCL
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
284-288Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM127086
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH112205
Pays : United States
Organisme : NIDA NIH HHS
ID : R21 DA042298
Pays : United States
Organisme : European Research Council
ID : 639125
Pays : International
Organisme : NINDS NIH HHS
ID : F31 NS093917
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : U24 DK116195
Pays : United States
Commentaires et corrections
Type : ErratumIn
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