Chrysin reduces the activity and protein level of mature forms of sterol regulatory element-binding proteins.

Animals Cell Line, Tumor Cholesterol / biosynthesis Fatty Acid Synthases / genetics Fatty Acids / biosynthesis Flavonoids / pharmacology Gene Expression Regulation / drug effects Humans Promoter Regions, Genetic Proteolysis Sterol Regulatory Element Binding Proteins / antagonists & inhibitors
Chrysin SREBP protein degradation

Journal

Bioscience, biotechnology, and biochemistry
ISSN: 1347-6947
Titre abrégé: Biosci Biotechnol Biochem
Pays: England
ID NLM: 9205717

Informations de publication

Date de publication:
Sep 2019
Historique:
pubmed: 26 4 2019
medline: 13 9 2019
entrez: 26 4 2019
Statut: ppublish

Résumé

Sterol regulatory element-binding proteins (SREBPs) are transcription factors that regulate the expression of genes involved in fatty acid and cholesterol biosynthetic pathways. The present study showed that the flavonoid chrysin impairs the fatty acid synthase promoter. Chrysin reduces the expression of SREBP target genes, such as fatty acid synthase, in human hepatoma Huh-7 cells and impairs

Identifiants

DOI: 10.1080/09168451.2019.1608806 PMID: 31021712
pubmed: 31021712
doi: 10.1080/09168451.2019.1608806
doi:

Substances chimiques

Fatty Acids 0
Flavonoids 0
Sterol Regulatory Element Binding Proteins 0
chrysin 3CN01F5ZJ5
Cholesterol 97C5T2UQ7J
Fatty Acid Synthases EC 2.3.1.85

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1740-1746

Auteurs

Masamori Iwase (M)

a Food Biochemistry laboratory, Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Tokyo , Japan.

Kyoko Watanabe (K)

b Department of Agricultural Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture , Tokyo , Japan.

Makoto Shimizu (M)

a Food Biochemistry laboratory, Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Tokyo , Japan.

Tsukasa Suzuki (T)

b Department of Agricultural Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture , Tokyo , Japan.

Yuji Yamamoto (Y)

b Department of Agricultural Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture , Tokyo , Japan.

Jun Inoue (J)

a Food Biochemistry laboratory, Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Tokyo , Japan.
b Department of Agricultural Chemistry, Faculty of Applied Biosciences, Tokyo University of Agriculture , Tokyo , Japan.

Ryuichiro Sato (R)

a Food Biochemistry laboratory, Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Tokyo , Japan.
c Nutri-Life Science laboratory, Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Tokyo , Japan.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chrysin reduces the activity and protein level...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Chrysin reduces the activity and protein level...
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholestérol › Chrysin reduces the activity and protein level...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Acyltransferases › Acyl-carrier protein S-malonyltransferase › Fatty acid synthases › Chrysin reduces the activity and protein level...
questionsmedicales.fr › Lipides › Acides gras › Chrysin reduces the activity and protein level...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Chrysin reduces the activity and protein level...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Chrysin reduces the activity and protein level...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Chrysin reduces the activity and protein level...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Régions promotrices (génétique) › Chrysin reduces the activity and protein level...
questionsmedicales.fr › Métabolisme › Protéolyse › Chrysin reduces the activity and protein level...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Facteurs de transcription à motifs basiques hélice-boucle-hélice et à glissière à leucines › Protéines de liaison à l'élément de régulation des stérols › Chrysin reduces the activity and protein level...