Renoprotective Effects of Alpha Lipoic Acid on Iron Overload-Induced Kidney Injury in Rats by Suppressing NADPH Oxidase 4 and p38 MAPK Signaling.
Animals
Cell Adhesion Molecules
/ genetics
Gene Expression
/ drug effects
Iron Overload
/ complications
Kidney
/ drug effects
Kidney Diseases
/ etiology
MAP Kinase Signaling System
/ drug effects
Male
NADPH Oxidase 4
/ antagonists & inhibitors
Protective Agents
/ pharmacology
Rats, Wistar
Thioctic Acid
/ pharmacology
Tumor Necrosis Factor-alpha
/ genetics
p38 Mitogen-Activated Protein Kinases
/ antagonists & inhibitors
Alpha lipoic acid
Iron
Kidney
NOX4
Oxidative stress
p38 MAPK
Journal
Biological trace element research
ISSN: 1559-0720
Titre abrégé: Biol Trace Elem Res
Pays: United States
ID NLM: 7911509
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
13
03
2019
accepted:
11
04
2019
pubmed:
27
4
2019
medline:
9
6
2020
entrez:
27
4
2019
Statut:
ppublish
Résumé
We aimed to investigate the protective effect of alpha lipoic acid (ALA), a powerful antioxidant, against oxidative kidney damage induced by iron overload in rats. Male Wistar albino rats were separated into groups: control (n = 7), ALA (100 mg/kg (n = 7), iron sucrose (IS) (40 mg/kg) (n = 7), and IS + ALA (40 mg/kg IS administration followed by 100 mg/kg ALA) (n = 7). IS and ALA were injected weekly for 4 weeks via the tail vein. Blood and kidneys were collected at sacrification on day 29. Serum creatinine and iron levels were analyzed. Tubular injury and iron deposits were evaluated histopathologically. Additionally, iron, malondialdehyde (MDA), superoxide dismutase (SOD), catalase, and glutathione (GSH) levels and mRNA expressions of the subunits of NADPH oxidase, known as NOX4 and p22
Identifiants
pubmed: 31025242
doi: 10.1007/s12011-019-01733-3
pii: 10.1007/s12011-019-01733-3
doi:
Substances chimiques
Cell Adhesion Molecules
0
Havcr1protein, rat
0
Protective Agents
0
Tumor Necrosis Factor-alpha
0
Thioctic Acid
73Y7P0K73Y
NADPH Oxidase 4
EC 1.6.3.-
p38 Mitogen-Activated Protein Kinases
EC 2.7.11.24
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
483-493Références
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