Encoded Library Technologies as Integrated Lead Finding Platforms for Drug Discovery.
DNA-encoded libraries
Encoded Library Technologies
drug discovery
high-throughput screening
integrated lead finding
lead generation
mRNA display
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
25 Apr 2019
25 Apr 2019
Historique:
received:
27
03
2019
revised:
17
04
2019
accepted:
21
04
2019
entrez:
28
4
2019
pubmed:
28
4
2019
medline:
20
8
2019
Statut:
epublish
Résumé
The scope of targets investigated in pharmaceutical research is continuously moving into uncharted territory. Consequently, finding suitable chemical matter with current compound collections is proving increasingly difficult. Encoded library technologies enable the rapid exploration of large chemical space for the identification of ligands for such targets. These binders facilitate drug discovery projects both as tools for target validation, structural elucidation and assay development as well as starting points for medicinal chemistry. Novartis internalized two complementing encoded library platforms to accelerate the initiation of its drug discovery programs. For the identification of low-molecular weight ligands, we apply DNA-encoded libraries. In addition, encoded peptide libraries are employed to identify cyclic peptides. This review discusses how we apply these two platforms in our research and why we consider it beneficial to run both pipelines in-house.
Identifiants
pubmed: 31027189
pii: molecules24081629
doi: 10.3390/molecules24081629
pmc: PMC6514559
pii:
doi:
Substances chimiques
RNA, Messenger
0
Small Molecule Libraries
0
Types de publication
Journal Article
Review
Langues
eng
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