Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction.

3T3 Cells Animals Cell Line Diabetes Mellitus, Type 2 / metabolism Dinoprostone / analogs & derivatives HEK293 Cells Homeostasis / immunology Humans Hydroxyprostaglandin Dehydrogenases / genetics Insulin Resistance / genetics Intra-Abdominal Fat / cytology Jurkat Cells Lymphocyte Activation / immunology Male Mice Mice, Knockout STAT5 Transcription Factor / metabolism T-Lymphocytes, Regulatory / enzymology
Foxp3 HPGD PGE(2) adipose tissue regulatory T cells suppressive function type 2 diabetes

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
21 05 2019
Historique:
received: 04 04 2018
revised: 20 12 2018
accepted: 15 03 2019
pubmed: 28 4 2019
medline: 18 10 2019
entrez: 28 4 2019
Statut: ppublish

Résumé

Regulatory T cells (Treg cells) are important for preventing autoimmunity and maintaining tissue homeostasis, but whether Treg cells can adopt tissue- or immune-context-specific suppressive mechanisms is unclear. Here, we found that the enzyme hydroxyprostaglandin dehydrogenase (HPGD), which catabolizes prostaglandin E

Identifiants

DOI: 10.1016/j.immuni.2019.03.014 PMID: 31027998
pubmed: 31027998
pii: S1074-7613(19)30131-1
doi: 10.1016/j.immuni.2019.03.014
pii:
doi:

Substances chimiques

STAT5 Transcription Factor 0
15-ketoprostaglandin E2 2S0F1FTK13
Hydroxyprostaglandin Dehydrogenases EC 1.1.1.-
Dinoprostone K7Q1JQR04M

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1232-1248.e14

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Lisa Schmidleithner (L)

Molecular Immunology in Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Str. 27, 53127 Bonn, Germany; LIMES-Institute, Laboratory for Genomics and Immunoregulation, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany.

Yasser Thabet (Y)

LIMES-Institute, Laboratory for Genomics and Immunoregulation, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany.

Eva Schönfeld (E)

LIMES-Institute, Laboratory for Genomics and Immunoregulation, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany.

Maren Köhne (M)

Molecular Immunology in Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Str. 27, 53127 Bonn, Germany; LIMES-Institute, Laboratory for Genomics and Immunoregulation, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany.

Daniel Sommer (D)

LIMES-Institute, Laboratory for Genomics and Immunoregulation, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany.

Zeinab Abdullah (Z)

Institute of Experimental Immunology, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.

Timothy Sadlon (T)

Molecular Immunology, Robinson Research Institute, University of Adelaide, Norwich Centre, 55 King William St, North Adelaide, SA 5006, Australia.

Collins Osei-Sarpong (C)

Molecular Immunology in Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Str. 27, 53127 Bonn, Germany; LIMES-Institute, Laboratory for Genomics and Immunoregulation, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany.

Kotha Subbaramaiah (K)

Department of Medicine, Weill Cornell Medical College, 525 E. 68(th) Street, New York, NY 10065, USA.

Francesca Copperi (F)

Institute of Pharmacology and Toxicology, University of Bonn, 53127 Bonn, Germany.

Kristian Haendler (K)

LIMES-Institute, Laboratory for Genomics and Immunoregulation, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany; PRECISE, Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn, Sigmund-Freud-Str. 27, 53127 Bonn, Germany.

Tamas Varga (T)

Molecular Immunology in Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Str. 27, 53127 Bonn, Germany.

Oliver Schanz (O)

LIMES-Institute, Immunology & Environment, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany.

Svenja Bourry (S)

Molecular Immunology in Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Str. 27, 53127 Bonn, Germany.

Kevin Bassler (K)

LIMES-Institute, Laboratory for Genomics and Immunoregulation, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany.

Wolfgang Krebs (W)

LIMES-Institute, Laboratory for Genomics and Immunoregulation, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany.

Annika E Peters (AE)

LIMES-Institute, Laboratory for Genomics and Immunoregulation, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany; Institute of Experimental Immunology, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.

Ann-Kathrin Baumgart (AK)

LIMES-Institute, Laboratory for Genomics and Immunoregulation, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany; Institute of Experimental Immunology, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.

Maria Schneeweiss (M)

LIMES-Institute, Laboratory for Genomics and Immunoregulation, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany.

Kathrin Klee (K)

LIMES-Institute, Laboratory for Genomics and Immunoregulation, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany.

Susanne V Schmidt (SV)

LIMES-Institute, Laboratory for Genomics and Immunoregulation, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany.

Simone Nüssing (S)

LIMES-Institute, Laboratory for Genomics and Immunoregulation, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany.

Jil Sander (J)

LIMES-Institute, Laboratory for Genomics and Immunoregulation, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany.

Naganari Ohkura (N)

Laboratory of Experimental Immunology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan.

Andreas Waha (A)

Department of Neuropathology, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.

Tim Sparwasser (T)

Institute for Medical Microbiology and Hygiene (IMMH), Johannes Gutenberg-University Mainz, Obere Zahlbacherstr. 67, 55131 Mainz, Germany.

F Thomas Wunderlich (FT)

Max Planck Institute for Metabolism Research, Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), Gleueler Str. 50, 50931 Cologne, Germany.

Irmgard Förster (I)

LIMES-Institute, Immunology & Environment, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany.

Thomas Ulas (T)

LIMES-Institute, Laboratory for Genomics and Immunoregulation, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany.

Heike Weighardt (H)

LIMES-Institute, Immunology & Environment, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany.

Shimon Sakaguchi (S)

Laboratory of Experimental Immunology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan.

Alexander Pfeifer (A)

Institute of Pharmacology and Toxicology, University of Bonn, 53127 Bonn, Germany.

Matthias Blüher (M)

Department of Medicine, University of Leipzig, Liebigstraße 20, 04103 Leipzig, Germany.

Andrew J Dannenberg (AJ)

Department of Medicine, Weill Cornell Medical College, 525 E. 68(th) Street, New York, NY 10065, USA.

Nerea Ferreirós (N)

Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe-University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.

Louis J Muglia (LJ)

Cincinnati Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Claudia Wickenhauser (C)

Institute for Pathology, Martin-Luther University Halle - Wittenberg, Magdeburger Str. 14, 06112 Halle (Saale), Germany.

Simon C Barry (SC)

Molecular Immunology, Robinson Research Institute, University of Adelaide, Norwich Centre, 55 King William St, North Adelaide, SA 5006, Australia.

Joachim L Schultze (JL)

LIMES-Institute, Laboratory for Genomics and Immunoregulation, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany; PRECISE, Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn, Sigmund-Freud-Str. 27, 53127 Bonn, Germany.

Marc Beyer (M)

Molecular Immunology in Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Str. 27, 53127 Bonn, Germany; LIMES-Institute, Laboratory for Genomics and Immunoregulation, University of Bonn, Carl-Troll-Str. 31, 53115 Bonn, Germany; PRECISE, Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn, Sigmund-Freud-Str. 27, 53127 Bonn, Germany. Electronic address: marc.beyer@dzne.de.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Cellules 3T3 › Enzymatic Activity of HPGD in Treg Cells...
questionsmedicales.fr › Eucaryotes › Animaux › Enzymatic Activity of HPGD in Treg Cells...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Enzymatic Activity of HPGD in Treg Cells...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Enzymatic Activity of HPGD in Treg Cells...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Éicosanoïdes › Prostaglandines › Prostaglandines E › Dinoprostone › Enzymatic Activity of HPGD in Treg Cells...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Enzymatic Activity of HPGD in Treg Cells...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Enzymatic Activity of HPGD in Treg Cells...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Enzymatic Activity of HPGD in Treg Cells...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › NAD (+) and NADP (+) dependent Alcohol oxidoreductases › Hydroxyprostaglandine dehydrogenases › Enzymatic Activity of HPGD in Treg Cells...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Insulinorésistance › Enzymatic Activity of HPGD in Treg Cells...
questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Tissu adipeux blanc › Graisse abdominale › Graisse intra-abdominale › Enzymatic Activity of HPGD in Treg Cells...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Cellules Jurkat › Enzymatic Activity of HPGD in Treg Cells...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › Enzymatic Activity of HPGD in Treg Cells...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Enzymatic Activity of HPGD in Treg Cells...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Enzymatic Activity of HPGD in Treg Cells...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription STAT › Facteur de transcription STAT-5 › Enzymatic Activity of HPGD in Treg Cells...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Enzymatic Activity of HPGD in Treg Cells...