Reproducibility of broth microdilution MICs for the novel siderophore cephalosporin, cefiderocol, determined using iron-depleted cation-adjusted Mueller-Hinton broth.

Cations, Divalent Cephalosporins / pharmacology Culture Media / chemistry Gram-Negative Bacteria / drug effects Iron Microbial Sensitivity Tests Reproducibility of Results Siderophores / pharmacology Cefiderocol
Cation-adjusted Mueller-Hinton broth Cefiderocol Gram-negative bacilli Iron-depleted MIC Reproducibility Siderophore

Journal

Diagnostic microbiology and infectious disease
ISSN: 1879-0070
Titre abrégé: Diagn Microbiol Infect Dis
Pays: United States
ID NLM: 8305899

Informations de publication

Date de publication:
Aug 2019
Historique:
received: 19 12 2018
revised: 04 03 2019
accepted: 11 03 2019
pubmed: 29 4 2019
medline: 23 11 2019
entrez: 29 4 2019
Statut: ppublish

Résumé

In 2017, the Clinical and Laboratory Standards Institute (CLSI) Subcommittee on Antimicrobial Susceptibility Testing approved the use of iron-depleted cation-adjusted Mueller-Hinton broth (ID-CAMHB) prepared with Chelex® 100 resin (Bio-Rad Laboratories, Hercules, CA) to determine MICs for cefiderocol. The current study examined the reproducibility of cefiderocol MICs generated for 19 clinical isolates of Gram-negative bacilli, with CAMHB produced by three manufacturers; each of the 19 isolates was tested for 10 replicates in ID-CAMHB from each manufacturer. When analyzed by individual media lot, greater than 95% of MIC results were within ± one doubling-dilution of the mode for each of the 19 isolates tested. The remaining 5.0% of MIC results were within ± two doubling-dilutions of the modal MIC. For all media lots combined, 92.2% of MIC results were within ± one doubling-dilution of the modal MIC for each isolate, 99.8% were within ± two doubling-dilutions and 100% were within three doubling-dilutions.

Identifiants

DOI: 10.1016/j.diagmicrobio.2019.03.003 PMID: 31029489
pubmed: 31029489
pii: S0732-8893(18)30788-0
doi: 10.1016/j.diagmicrobio.2019.03.003
pii:
doi:

Substances chimiques

Cations, Divalent 0
Cephalosporins 0
Culture Media 0
Siderophores 0
Iron E1UOL152H7

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

321-325

Informations de copyright

Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Meredith A Hackel (MA)

International Health Management Associates, Inc., Schaumburg, IL, USA. Electronic address: mhackel@ihmainc.com.

Masakatsu Tsuji (M)

Drug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd., Osaka, Japan.

Yoshinori Yamano (Y)

Pharmaceutical Research Division, Shionogi & Co., Ltd., Osaka, Japan.

Roger Echols (R)

Clinical Development and Medical Affairs, ID3C, LLC, Easton, CT, USA.

James A Karlowsky (JA)

Department of Medical Microbiology and Infectious Diseases, College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.

Daniel F Sahm (DF)

International Health Management Associates, Inc., Schaumburg, IL, USA.

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Cations › Cations divalents › Reproducibility of broth microdilution MICs...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Céphalosporines › Reproducibility of broth microdilution MICs...
questionsmedicales.fr › Équipement et fournitures › Milieux de culture › Reproducibility of broth microdilution MICs...
questionsmedicales.fr › Bactéries › Bactéries à Gram négatif › Reproducibility of broth microdilution MICs...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Fer › Reproducibility of broth microdilution MICs...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Reproducibility of broth microdilution MICs...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Reproductibilité des résultats › Reproducibility of broth microdilution MICs...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents séquestrants › Chélateurs › Agents chélateurs du fer › Sidérophores › Reproducibility of broth microdilution MICs...