Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites.

Animals Cell Survival HT29 Cells Humans Inositol Phosphates / metabolism Protein Kinases / isolation & purification Sf9 Cells Spodoptera
CRISPR Cas9 gene editing MLKL NMR structure determination cell death inositol phosphate inositol phosphate kinase membrane permeabilization metabolite necroptosis plasma membrane rupture

Journal

Cell chemical biology
ISSN: 2451-9448
Titre abrégé: Cell Chem Biol
Pays: United States
ID NLM: 101676030

Informations de publication

Date de publication:
20 06 2019
Historique:
received: 31 08 2018
revised: 08 02 2019
accepted: 15 03 2019
pubmed: 30 4 2019
medline: 22 4 2020
entrez: 30 4 2019
Statut: ppublish

Résumé

Necroptosis is an inflammatory form of programmed cell death executed through plasma membrane rupture by the pseudokinase mixed lineage kinase domain-like (MLKL). We previously showed that MLKL activation requires metabolites of the inositol phosphate (IP) pathway. Here we reveal that I(1,3,4,6)P

Identifiants

DOI: 10.1016/j.chembiol.2019.03.010 PMID: 31031142 PMC: PMC6588482
pubmed: 31031142
pii: S2451-9456(19)30106-0
doi: 10.1016/j.chembiol.2019.03.010
pmc: PMC6588482
mid: NIHMS1524562
pii:
doi:

Substances chimiques

Inositol Phosphates 0
MLKL protein, human EC 2.7.-
Protein Kinases EC 2.7.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

863-877.e7

Subventions

Organisme : NIAID NIH HHS
ID : DP2 AI104557
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM124404
Pays : United States
Organisme : NCI NIH HHS
ID : R25 CA023944
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007328
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA169291
Pays : United States
Organisme : NHLBI NIH HHS
ID : F30 HL143826
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI140186
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI044828
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI044828
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA021765
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA231620
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Références

Biophys J. 2000 Mar;78(3):1606-19
pubmed: 10692345
Nat Rev Mol Cell Biol. 2001 May;2(5):327-38
pubmed: 11331907
Biochem J. 2002 Sep 1;366(Pt 2):549-56
pubmed: 12027805
J Mol Biol. 2002 May 24;319(1):209-27
pubmed: 12051947
J Biol Chem. 2002 Nov 15;277(46):43836-43
pubmed: 12223481
J Comput Chem. 2004 Oct;25(13):1605-12
pubmed: 15264254
Mol Cell. 2004 Sep 10;15(5):689-701
pubmed: 15350214
Science. 2004 Sep 3;305(5689):1471-4
pubmed: 15353805
Mol Cell. 2005 Apr 15;18(2):201-12
pubmed: 15837423
J Physiol. 2005 Jul 15;566(Pt 2):295-300
pubmed: 15860522
Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8454-9
pubmed: 15939867
Science. 2005 Sep 2;309(5740):1534-9
pubmed: 16141067
J Magn Reson. 2006 Feb;178(2):334-9
pubmed: 16269260
Biochem Biophys Res Commun. 2006 Jan 6;339(1):209-16
pubmed: 16293229
Nat Chem Biol. 2005 Jul;1(2):112-9
pubmed: 16408008
J Biol Chem. 2006 Dec 8;281(49):38109-16
pubmed: 17050532
Nature. 2007 Apr 5;446(7136):640-5
pubmed: 17410169
Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15653-8
pubmed: 17895383
J Biomol NMR. 2007 Dec;39(4):275-89
pubmed: 17955183
Nat Protoc. 2007;2(11):2728-33
pubmed: 18007608
Nat Rev Mol Cell Biol. 2008 Feb;9(2):112-24
pubmed: 18216768
Science. 2008 Oct 10;322(5899):265-8
pubmed: 18845756
BMC Struct Biol. 2008 Nov 14;8:49
pubmed: 19014592
Rapid Commun Mass Spectrom. 2009 Mar;23(5):705-12
pubmed: 19191261
J Biomol NMR. 2009 Aug;44(4):213-23
pubmed: 19548092
Cell. 2009 Jul 23;138(2):229-32
pubmed: 19632174
J Struct Biol. 2010 Oct;172(1):3-13
pubmed: 20541610
Methods Mol Biol. 2010;645:47-60
pubmed: 20645180
Mol Biol Cell. 2010 Dec;21(23):4061-7
pubmed: 21115850
Cell. 2010 Dec 10;143(6):1030-1030.e1
pubmed: 21145466
Nature. 2011 Mar 17;471(7338):310-2
pubmed: 21412328
Nature. 2011 Apr 14;472(7342):238-42
pubmed: 21441902
Sci Signal. 2011 Aug 23;4(188):re1
pubmed: 21878680
Nature. 2012 Jan 09;481(7381):335-40
pubmed: 22230954
Cell. 2012 Jan 20;148(1-2):213-27
pubmed: 22265413
Protein Sci. 2012 May;21(5):737-42
pubmed: 22362712
Cell. 2012 Jul 20;150(2):339-50
pubmed: 22817896
J Biol Chem. 2012 Oct 12;287(42):35360-9
pubmed: 22896696
Nat Struct Mol Biol. 2012 Sep;19(9):876-83
pubmed: 22902369
J Vis Exp. 2012 Oct 05;(68):null
pubmed: 23070252
Methods Mol Biol. 2013;967:39-55
pubmed: 23296720
Curr Protoc Protein Sci. 2013 Feb;Chapter 20:Unit20.12
pubmed: 23377850
Curr Opin Virol. 2013 Jun;3(3):296-306
pubmed: 23773332
Immunity. 2013 Sep 19;39(3):443-53
pubmed: 24012422
Methods Mol Biol. 2014;1091:55-72
pubmed: 24203324
Nat Cell Biol. 2014 Jan;16(1):55-65
pubmed: 24316671
Cell Res. 2014 Jan;24(1):105-21
pubmed: 24366341
Mol Cell. 2014 Apr 10;54(1):133-146
pubmed: 24703947
Cell. 2014 May 22;157(5):1189-202
pubmed: 24813850
Cell Rep. 2014 May 22;7(4):971-81
pubmed: 24813885
Nat Commun. 2014 Jun 24;5:4178
pubmed: 24956979
Structure. 2014 Oct 7;22(10):1489-500
pubmed: 25220470
Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15072-7
pubmed: 25288762
Trends Biochem Sci. 2014 Dec;39(12):587-93
pubmed: 25455759
J Biol Chem. 1989 Nov 5;264(31):18489-93
pubmed: 2553710
Cell Rep. 2015 Mar 24;10(11):1836-49
pubmed: 25801023
Virology. 2015 May;479-480:160-6
pubmed: 25819165
PLoS One. 2015 May 21;10(5):e0126420
pubmed: 25997164
Cell Death Differ. 2016 Jan;23(1):76-88
pubmed: 26024392
Biochem J. 2015 Oct 15;471(2):255-65
pubmed: 26283547
Methods Enzymol. 2015;562:109-33
pubmed: 26412649
Biosci Rep. 2015 Dec 24;36(1):e00291
pubmed: 26704887
Mol Cell. 2016 Feb 18;61(4):589-601
pubmed: 26853145
Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3503-8
pubmed: 26976604
Cell Res. 2016 May;26(5):517-28
pubmed: 27033670
Nature. 2016 Apr 14;532(7598):245-9
pubmed: 27049944
Cell Death Differ. 2016 Sep 1;23(9):1565-76
pubmed: 27177019
Sci Rep. 2016 Jul 01;6:28973
pubmed: 27363488
Nature. 2016 Jul 7;535(7610):159-63
pubmed: 27383987
Methods Mol Biol. 2016;1432:187-202
pubmed: 27485337
Science. 2016 Aug 5;353(6299):603-8
pubmed: 27493188
Immunity. 2016 Sep 20;45(3):513-526
pubmed: 27523270
Mol Cell Biol. 2017 Feb 15;37(5):
pubmed: 27920255
Nat Rev Mol Cell Biol. 2017 Feb;18(2):127-136
pubmed: 27999438
Protein Sci. 2017 Mar;26(3):436-451
pubmed: 28019676
Nat Microbiol. 2017 Jan 13;2:16258
pubmed: 28085133
Trends Pharmacol Sci. 2017 Mar;38(3):202-225
pubmed: 28126382
Cell Host Microbe. 2017 Mar 8;21(3):290-293
pubmed: 28279333
Cell. 2017 Apr 6;169(2):286-300.e16
pubmed: 28388412
Trends Cancer. 2017 Apr;3(4):294-301
pubmed: 28451648
Cell Death Differ. 2017 Jul;24(7):1184-1195
pubmed: 28498367
Immunity. 2017 Jul 18;47(1):51-65.e7
pubmed: 28666573
Nat Neurosci. 2017 Sep;20(9):1236-1246
pubmed: 28758999
Cell Chem Biol. 2017 Dec 21;24(12):1445-1454.e8
pubmed: 29033315
Science. 2017 Dec 8;358(6368):1278-1283
pubmed: 29146870
Cell Death Differ. 2018 Sep;25(9):1567-1580
pubmed: 29445128
Cell Rep. 2018 Feb 20;22(8):2066-2079
pubmed: 29466734
Cell Rep. 2018 May 15;23(7):2083-2094.e6
pubmed: 29768206
Elife. 2018 May 31;7:
pubmed: 29848441
Mol Cell. 2018 Jun 7;70(5):936-948.e7
pubmed: 29883610
Nat Commun. 2018 Jun 21;9(1):2422
pubmed: 29930286
Nature. 2018 Aug;560(7719):509-512
pubmed: 30069050
Sci Immunol. 2018 Aug 24;3(26):
pubmed: 30143556
J Vis Exp. 2018 Aug 7;(138):
pubmed: 30148498
Trends Biochem Sci. 2019 Jan;44(1):53-63
pubmed: 30509860
Biochem Biophys Res Commun. 1987 Dec 31;149(3):874-81
pubmed: 3426614
J Bacteriol. 1974 Sep;119(3):736-47
pubmed: 4604283
Biochem J. 1994 Oct 15;303 ( Pt 2):517-25
pubmed: 7980412
J Mol Graph. 1996 Feb;14(1):51-5, 29-32
pubmed: 8744573
Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):905-21
pubmed: 9757107

Auteurs

Dan E McNamara (DE)

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Cole M Dovey (CM)

Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Andrew T Hale (AT)

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

Giovanni Quarato (G)

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Christy R Grace (CR)

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Cristina D Guibao (CD)

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Jonathan Diep (J)

Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Amanda Nourse (A)

Molecular Interaction Analysis Shared Resource, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Casey R Cai (CR)

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Hong Wu (H)

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Ravi C Kalathur (RC)

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Douglas R Green (DR)

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

John D York (JD)

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

Jan E Carette (JE)

Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: carette@stanford.edu.

Tudor Moldoveanu (T)

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: tudor.moldoveanu@stjude.org.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Direct Activation of Human MLKL by a Select...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Direct Activation of Human MLKL by a Select...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HT29 › Direct Activation of Human MLKL by a Select...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Direct Activation of Human MLKL by a Select...
questionsmedicales.fr › Glucides › Oses phosphates › Inositol phosphates › Direct Activation of Human MLKL by a Select...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Alcohol Group Acceptor) › Protein kinases › Direct Activation of Human MLKL by a Select...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Cellules Sf9 › Direct Activation of Human MLKL by a Select...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Lepidoptera › Papillons de nuit › Spodoptera › Direct Activation of Human MLKL by a Select...