Genes, Roommates, and Residence Halls: A Multidimensional Study of the Role of Peer Drinking on College Students' Alcohol Use.
Alcohol
College Students
Gene-Environment Interaction
Genetic Predisposition
Peer Drinking
Journal
Alcoholism, clinical and experimental research
ISSN: 1530-0277
Titre abrégé: Alcohol Clin Exp Res
Pays: England
ID NLM: 7707242
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
14
09
2018
accepted:
21
03
2019
pubmed:
30
4
2019
medline:
4
9
2020
entrez:
30
4
2019
Statut:
ppublish
Résumé
Peer drinking is one of the most robust predictors of college students' alcohol use and can moderate students' genetic risk for alcohol use. Peer effect research generally suffers from 2 problems: selection into peer groups and relying more on perceptions of peer alcohol use than peers' self-report. The goal of the present study was to overcome those limitations by capitalizing on a genetically informed sample of randomly assigned college roommates to examine multiple dimensions of peer influence and the interplay between peer effects and genetic predisposition on alcohol use, in the form of polygenic scores. We used a subsample (n = 755) of participants from a university-wide, longitudinal study at a large, diverse, urban university. Participants reported their own alcohol use during fall and spring and their perceptions of college peers' alcohol use in spring. We matched individuals into their rooms and residence halls to create a composite score of peer-reported alcohol use for each of those levels. We examined multiple dimensions of peer influence and whether peer influence moderated genetic predisposition to predict college students' alcohol use using multilevel models to account for clustering at the room and residence hall level. We found that polygenic scores (β = 0.12), perceptions of peer drinking (β = 0.37), and roommates' self-reported drinking (β = 0.10) predicted alcohol use (all ps < 0.001), while average alcohol use across residence hall did not (β = -0.01, p = 0.86). We found no evidence for interactions between peer influence and genome-wide polygenic scores for alcohol use. Our findings underscore the importance of genetic predisposition on individual alcohol use and support the potentially causal nature of the association between peer influence and alcohol use.
Sections du résumé
BACKGROUND
Peer drinking is one of the most robust predictors of college students' alcohol use and can moderate students' genetic risk for alcohol use. Peer effect research generally suffers from 2 problems: selection into peer groups and relying more on perceptions of peer alcohol use than peers' self-report. The goal of the present study was to overcome those limitations by capitalizing on a genetically informed sample of randomly assigned college roommates to examine multiple dimensions of peer influence and the interplay between peer effects and genetic predisposition on alcohol use, in the form of polygenic scores.
METHODS
We used a subsample (n = 755) of participants from a university-wide, longitudinal study at a large, diverse, urban university. Participants reported their own alcohol use during fall and spring and their perceptions of college peers' alcohol use in spring. We matched individuals into their rooms and residence halls to create a composite score of peer-reported alcohol use for each of those levels. We examined multiple dimensions of peer influence and whether peer influence moderated genetic predisposition to predict college students' alcohol use using multilevel models to account for clustering at the room and residence hall level.
RESULTS
We found that polygenic scores (β = 0.12), perceptions of peer drinking (β = 0.37), and roommates' self-reported drinking (β = 0.10) predicted alcohol use (all ps < 0.001), while average alcohol use across residence hall did not (β = -0.01, p = 0.86). We found no evidence for interactions between peer influence and genome-wide polygenic scores for alcohol use.
CONCLUSIONS
Our findings underscore the importance of genetic predisposition on individual alcohol use and support the potentially causal nature of the association between peer influence and alcohol use.
Identifiants
pubmed: 31034622
doi: 10.1111/acer.14037
pmc: PMC6561118
mid: NIHMS1020595
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1254-1262Subventions
Organisme : NIAAA NIH HHS
ID : P20 AA107828
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR031990
Pays : United States
Organisme : NIAAA NIH HHS
ID : F31 AA027130
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH113848
Pays : United States
Organisme : NIAAA NIH HHS
ID : P50 AA022537
Pays : United States
Organisme : NIAAA NIH HHS
ID : K01 AA024152
Pays : United States
Organisme : NIAAA NIH HHS
ID : K02 AA018755
Pays : United States
Organisme : NIAAA NIH HHS
ID : R37 AA011408
Pays : United States
Investigateurs
Kimberly Pedersen
(K)
Nathaniel Thomas
(N)
Amy E Adkins
(AE)
Thomas Bannard
(T)
Seung B Cho
(SB)
Erin C Berenz
(EC)
Erin Caraway
(E)
James S Clifford
(JS)
Megan Cooke
(M)
Elizabeth Do
(E)
Alexis C Edwards
(AC)
Neeru Goyal
(N)
Laura M Hack
(LM)
Lisa J Halberstadt
(LJ)
Sage Hawn
(S)
Sally Kuo
(S)
Emily Lasko
(E)
Jennifer Lend
(J)
Mackenzie Lind
(M)
Elizabeth Long
(E)
Alexandra Martelli
(A)
Jacquelyn L Meyers
(JL)
Kerry Mitchell
(K)
Ashlee Moore
(A)
Arden Moscati
(A)
Aashir Nasim
(A)
Jill Opalesky
(J)
Cassie Overstreet
(C)
A Christian Pais
(AC)
Kimberly Pedersen
(K)
Tarah Raldiris
(T)
Jessica Salvatore
(J)
Jeanne Savage
(J)
Rebecca Smith
(R)
David Sosnowski
(D)
Jinni Su
(J)
Chloe Walker
(C)
Marcie Walsh
(M)
Teresa Willoughby
(T)
Madison Woodroof
(M)
Jia Yan
(J)
Cuie Sun
(C)
Brandon Wormley
(B)
Brien Riley
(B)
Roseann Peterson
(R)
Bradley T Webb
(BT)
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2019 by the Research Society on Alcoholism.
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