Effect of Protein-Fortified Diet on Nitrogen Balance in Critically Ill Patients: Results from the OPINiB Trial.
energy intake
intensive care unit
nitrogen balance
nutritional therapy
protein intake
randomized controlled trial
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
28 Apr 2019
28 Apr 2019
Historique:
received:
11
04
2019
revised:
24
04
2019
accepted:
26
04
2019
entrez:
1
5
2019
pubmed:
1
5
2019
medline:
30
11
2019
Statut:
epublish
Résumé
Nitrogen balance (NB) is considered a good marker of adequate protein intake and it has been suggested to be a good predictor of patients' health outcomes. However, in literature, there is a lack of large randomized trials examining NB-guided protein intake in patients in intensive care units (ICUs). A randomized controlled trial enrolling patients admitted to ICU was done to compare changes in NB. Participants were randomized to a standard or protein-fortified diet (protein intake of 1.8 g/kg/day according to the guidelines of the Society of Critical Care Medicine and the American Society for Parenteral and Enteral Nutrition). The primary endpoint was represented by the NB on Day 1, 3, and study exit. Forty patients were enrolled in the study (19 in the protein-fortified group). The longitudinal analysis showed that, on Day 3, patients randomized to the protein-fortified diet were more likely (
Identifiants
pubmed: 31035354
pii: nu11050972
doi: 10.3390/nu11050972
pmc: PMC6567073
pii:
doi:
Substances chimiques
Dietary Proteins
0
Nitrogen
N762921K75
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
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