The hybrid allele 1 of carboxyl-ester lipase (CEL-HYB1) in Polish pediatric patients with chronic pancreatitis.
CEL-HYB1 allele
Chronic pancreatitis
Journal
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
ISSN: 1424-3911
Titre abrégé: Pancreatology
Pays: Switzerland
ID NLM: 100966936
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
07
02
2019
revised:
10
04
2019
accepted:
17
04
2019
pubmed:
1
5
2019
medline:
31
12
2019
entrez:
1
5
2019
Statut:
ppublish
Résumé
It has previously been reported in a European case-control study with patients from Germany and France that CEL-HYB1, a hybrid allele of the carboxyl ester lipase (CEL) gene and its pseudogene CELP, increases susceptibility to chronic pancreatitis (CP). Here, we aimed to replicate this finding in Polish pediatric patients with CP. The distribution of the CEL-HYB1 allele in a CP pediatric cohort (n = 147, median age at CP onset 7.6 years) with no history of alcohol/smoking abuse was compared with ethnically matched healthy controls (n = 500, median age 46 years). Screening was performed using long-range PCR followed by agarose gel-electrophoresis. We observed no significant difference in the carrier frequency of the CEL-HYB1 allele between CP patients (7/147, 4.8%) and controls (12/500, 2.4%; P = 0.16). This study found no statistically significant association between CEL-HYB1 and chronic pancreatitis in a cohort of Polish pediatric CP patients.
Identifiants
pubmed: 31036489
pii: S1424-3903(19)30094-8
doi: 10.1016/j.pan.2019.04.006
pii:
doi:
Substances chimiques
CEL protein, human
EC 3.1.1.3
Lipase
EC 3.1.1.3
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
531-534Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 IAP and EPC. Published by Elsevier B.V. All rights reserved.