Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis.


Journal

Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395

Informations de publication

Date de publication:
2019
Historique:
received: 22 06 2018
accepted: 16 01 2019
entrez: 1 5 2019
pubmed: 1 5 2019
medline: 24 4 2020
Statut: epublish

Résumé

Cytotoxic T lymphocyte (CTL) activation contributes to liver damage during sepsis, but the mechanisms involved are largely unknown. Understanding the underlying principle will permit interference with CTL activation and thus, provide a new therapeutic option.

Identifiants

pubmed: 31037153
doi: 10.7150/thno.28057
pii: thnov09p2003
pmc: PMC6485280
doi:

Substances chimiques

B7-H1 Antigen 0
Cd274 protein, mouse 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2003-2016

Déclaration de conflit d'intérêts

Competing Interests: The authors have declared that no competing interest exists.

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Auteurs

Andreas von Knethen (A)

Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany.
Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine & Pharmacology TMP, Frankfurt, Germany.

Anne Schäfer (A)

Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany.

Laura Kuchler (L)

Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany.

Tilo Knape (T)

Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine & Pharmacology TMP, Frankfurt, Germany.

Urs Christen (U)

Pharmazentrum/ZAFES Frankfurt, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany.

Edith Hintermann (E)

Pharmazentrum/ZAFES Frankfurt, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany.

Beate Fißlthaler (B)

Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe-University Frankfurt, Frankfurt, Germany.

Katrin Schröder (K)

Institute for Cardiovascular Physiology, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany.

Ralf P Brandes (RP)

Institute for Cardiovascular Physiology, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany.

Berit Genz (B)

Institute for Experimental Surgery, Rostock University Medical Center, Rostock, Germany.

Kerstin Abshagen (K)

Institute for Experimental Surgery, Rostock University Medical Center, Rostock, Germany.

Brigitte M Pützer (BM)

Institute of Experimental Gene Therapy and Cancer Research, Rostock University Medical Center, Rostock, Germany.

Lisa K Sha (LK)

Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany.

Andreas Weigert (A)

Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany.

Shahzad N Syed (SN)

Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany.

Martin Schulz (M)

Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany.

Ajay M Shah (AM)

King's College London, British Heart Foundation, Centre of Excellence, The James Black Centre, London, UK.

Andreas Ernst (A)

Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine & Pharmacology TMP, Frankfurt, Germany.
Pharmazentrum/ZAFES Frankfurt, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany.

Mateusz Putyrski (M)

Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine & Pharmacology TMP, Frankfurt, Germany.

Fabian Finkelmeier (F)

Georg Speyer Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt, Germany.

Marina Pesic (M)

Georg Speyer Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt, Germany.

Florian Greten (F)

Georg Speyer Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt, Germany.

Michael Hogardt (M)

Institute for Medical Microbiology and Infection Control, University Hospital Frankfurt, Paul-Ehrlich-Str. 40, Frankfurt am Main, Germany.

Volkhard A J Kempf (VAJ)

Institute for Medical Microbiology and Infection Control, University Hospital Frankfurt, Paul-Ehrlich-Str. 40, Frankfurt am Main, Germany.

Sandra Gunne (S)

Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine & Pharmacology TMP, Frankfurt, Germany.

Michael J Parnham (MJ)

Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine & Pharmacology TMP, Frankfurt, Germany.

Bernhard Brüne (B)

Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany.
Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine & Pharmacology TMP, Frankfurt, Germany.

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Classifications MeSH